P20800: Endothelin-2

General Information

Protein names	- Endothelin-2 - ET-2 - Preproendothelin-2 - PPET2
Gene names	EDN2
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P20800

5 N-termini

4 C-termini

6 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MVSVPTTWCS VALALLVALH EGKGQAAATL EQPASSSHAQ GTHLRLRRCS CSSWLDKECV
        70         80         90        100        110        120
YFCHLDIIWV NTPEQTAPYG LGNPPRRRRR SLPRRCQCSS ARDPACATFC LRRPWTEAGA
       130        140        150        160        170
VPSRKSPADV FQTGKTGATT GELLQRLRDI STVKSLFAKR QQEAMREPRS THSRWRKR

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

5 N-termini - 4 C-termini - 6 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
P20800-25-unknown	QAAATL...	25	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P20800-65-unknown	LDIIWV...	65	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26749
P20800-67-unknown	IIWVNT...	67	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26750
P20800-70-unknown	VNTPEQ...	70	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4728
P20800-70-unknown	VNTPEQ...	70	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8579
P20800-70-unknown	VNTPEQ...	70	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15801
P20800-80-unknown	GLGNPP...	80	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8426

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...VYFCHL	64	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26749
...FCHLDI	66	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26750
...LDIIWV	69	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4728
...LDIIWV	69	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8579
...LDIIWV	69	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15801
...QTAPYG	79	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8426

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
NEP_HUMAN	64	FCHL.\|.LDII	inferred from experiment	unknown	MEROPS	Hersh LB	Vijayaraghavan J et al.:The hydrolysis of endothelins b... (M13.001)	2201681,
NEP_HUMAN	66	HLDI.\|.IIWV	inferred from experiment	unknown	MEROPS	Hersh LB	Vijayaraghavan J et al.:The hydrolysis of endothelins b... (M13.001)	2201681,
CATE_HUMAN	69	IIWV.\|.VNTP	inferred from experiment	unknown	MEROPS	Cook ND	Robinson PS et al.:Kinetic parameters for the gene... (A01.010)	1599425,
ECE1_HUMAN	69	IIWV.\|.VNTP	inferred from experiment	unknown	MEROPS	Ahn K	Fahnoe DC et al.:Disulfide bonds in big ET-1 are... (M13.002)	10620363,
KELL_HUMAN	69	IIWV.\|.VNTP	inferred from experiment	unknown	MEROPS	Redman C	Lee S et al.:Proteolytic processing of big e... (M13.090)	10438732,
CMA1_HUMAN	79	APYG.\|.GLGN	inferred from experiment	unknown	MEROPS	Kido H	Nakano A et al.:Selective conversion of big end... (S01.140)	9257865,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)