P35318: ADM

General Information

Protein names	- ADM - Adrenomedullin - AM - Proadrenomedullin N-20 terminal peptide - ProAM N-terminal 20 peptide - PAMP - ProAM-N20
Gene names	ADM
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P35318

9 N-termini

8 C-termini

9 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MKLVSVALMY LGSLAFLGAD TARLDVASEF RKKWNKWALS RGKRELRMSS SYPTGLADVK
        70         80         90        100        110        120
AGPAQTLIRP QDMKGASRSP EDSSPDAARI RVKRYRQSMN NFQGLRSFGC RFGTCTVQKL
       130        140        150        160        170        180
AHQIYQFTDK DKDNVAPRSK ISPQGYGRRR RRSLPEAGPG RTLVSSKPQA HGAPAPPSGS

APHFL

Isoforms

Sequence View

Filter Information:

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Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
P35318-24-unknown	LDVASE...	24	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26759
P35318-30-unknown	FRKKWN...	30	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26760
P35318-34-unknown	WNKWAL...	34	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26761
P35318-37-unknown	WALSRG...	37	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26762
P35318-38-unknown	ALSRGK...	38	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26763
P35318-39-unknown	LSRGKR...	39	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26764
P35318-48-unknown	MSSSYP...	48	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000431438
P35318-127-unknown	FTDKDK...	127	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19068
P35318-128-unknown	TDKDKD...	128	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19069
P35318-128-unknown	TDKDKD...	128	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17606

Name

Sequence

Position

Modification

Evidence type

Method

Source (database)

Source (Lab)

Evidence name

Publications (PMID)

P35318-24-unknown

LDVASE...

inferred from cleavage

unknown

TopFIND

Inferred from cleavage TC26759

P35318-30-unknown

FRKKWN...

inferred from cleavage

unknown

TopFIND

Inferred from cleavage TC26760

P35318-34-unknown

WNKWAL...

inferred from cleavage

unknown

TopFIND

Inferred from cleavage TC26761

P35318-37-unknown

WALSRG...

inferred from cleavage

unknown

TopFIND

Inferred from cleavage TC26762

P35318-38-unknown

ALSRGK...

inferred from cleavage

unknown

TopFIND

Inferred from cleavage TC26763

P35318-39-unknown

LSRGKR...

inferred from cleavage

unknown

TopFIND

Inferred from cleavage TC26764

P35318-48-unknown

MSSSYP...

inferred from electronic annotation

unknown

Ensembl

inferred from ensembl protein ENSP00000431438

P35318-127-unknown

FTDKDK...

127

inferred from cleavage

unknown

TopFIND

Inferred from cleavage TC19068

P35318-128-unknown

TDKDKD...

128

inferred from cleavage

unknown

TopFIND

Inferred from cleavage TC19069

P35318-128-unknown

TDKDKD...

128

inferred from cleavage

unknown

TopFIND

Inferred from cleavage TC17606

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...ADTARL	23	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26759
...DVASEF	29	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26760
...EFRKKW	33	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26761
...KKWNKW	36	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26762
...KWNKWA	37	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26763
...WNKWAL	38	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26764
...HQIYQF	126	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19068
...QIYQFT	127	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19069
...QIYQFT	127	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17606

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
NEP_HUMAN	23	TARL.\|.LDVA	inferred from experiment	unknown	MEROPS	Eto T	Nagatomo Y et al.:Proadrenomedullin N-terminal 20... (M13.001)	8687431,
NEP_HUMAN	29	ASEF.\|.FRKK	inferred from experiment	unknown	MEROPS	Eto T	Nagatomo Y et al.:Proadrenomedullin N-terminal 20... (M13.001)	8687431,
NEP_HUMAN	33	RKKW.\|.WNKW	inferred from experiment	unknown	MEROPS	Eto T	Nagatomo Y et al.:Proadrenomedullin N-terminal 20... (M13.001)	8687431,
NEP_HUMAN	36	WNKW.\|.WALS	inferred from experiment	unknown	MEROPS	Eto T	Nagatomo Y et al.:Proadrenomedullin N-terminal 20... (M13.001)	8687431,
NEP_HUMAN	37	NKWA.\|.ALSR	inferred from experiment	unknown	MEROPS	Eto T	Nagatomo Y et al.:Proadrenomedullin N-terminal 20... (M13.001)	8687431,
NEP_HUMAN	38	KWAL.\|.LSRG	inferred from experiment	unknown	MEROPS	Eto T	Nagatomo Y et al.:Proadrenomedullin N-terminal 20... (M13.001)	8687431,
MEP1B_HUMAN	126	IYQF.\|.FTDK	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	127	YQFT.\|.TDKD	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	127	YQFT.\|.TDKD	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,

Protease

Position

Sequence

Evidence type

Method

Source (database)

Source (Lab)

Evidence name

Publications (PMIDs)

NEP_HUMAN

TARL.|.LDVA

inferred from experiment