TopFIND 4.0

P29144: Tripeptidyl-peptidase 2

General Information

Protein names
- Tripeptidyl-peptidase 2
- TPP-2
- 3.4.14.10
- Tripeptidyl aminopeptidase
- Tripeptidyl-peptidase II
- TPP-II
Gene names TPP2
Organism Homo sapiens
Protease Family S08.090
Protease ID S08.090
Chromosome location
UniProt ID P29144

7

N-termini

3

C-termini

2

Cleavages

2

Substrates

Sequence

        10         20         30         40         50         60 
MATAATEEPF PFHGLLPKKE TGAASFLCRY PEYDGRGVLI AVLDTGVDPG APGMQVTTDG 
        70         80         90        100        110        120 
KPKIVDIIDT TGSGDVNTAT EVEPKDGEIV GLSGRVLKIP ASWTNPSGKY HIGIKNGYDF 
       130        140        150        160        170        180 
YPKALKERIQ KERKEKIWDP VHRVALAEAC RKQEEFDVAN NGSSQANKLI KEELQSQVEL 
       190        200        210        220        230        240 
LNSFEKKYSD PGPVYDCLVW HDGEVWRACI DSNEDGDLSK STVLRNYKEA QEYGSFGTAE 
       250        260        270        280        290        300 
MLNYSVNIYD DGNLLSIVTS GGAHGTHVAS IAAGHFPEEP ERNGVAPGAQ ILSIKIGDTR 
       310        320        330        340        350        360 
LSTMETGTGL IRAMIEVINH KCDLVNYSYG EATHWPNSGR ICEVINEAVW KHNIIYVSSA 
       370        380        390        400        410        420 
GNNGPCLSTV GCPGGTTSSV IGVGAYVSPD MMVAEYSLRE KLPANQYTWS SRGPSADGAL 
       430        440        450        460        470        480 
GVSISAPGGA IASVPNWTLR GTQLMNGTSM SSPNACGGIA LILSGLKANN IDYTVHSVRR 
       490        500        510        520        530        540 
ALENTAVKAD NIEVFAQGHG IIQVDKAYDY LVQNTSFANK LGFTVTVGNN RGIYLRDPVQ 
       550        560        570        580        590        600 
VAAPSDHGVG IEPVFPENTE NSEKISLQLH LALTSNSSWV QCPSHLELMN QCRHINIRVD 
       610        620        630        640        650        660 
PRGLREGLHY TEVCGYDIAS PNAGPLFRVP ITAVIAAKVN ESSHYDLAFT DVHFKPGQIR 
       670        680        690        700        710        720 
RHFIEVPEGA TWAEVTVCSC SSEVSAKFVL HAVQLVKQRA YRSHEFYKFC SLPEKGTLTE 
       730        740        750        760        770        780 
AFPVLGGKAI EFCIARWWAS LSDVNIDYTI SFHGIVCTAP QLNIHASEGI NRFDVQSSLK 
       790        800        810        820        830        840 
YEDLAPCITL KNWVQTLRPV SAKTKPLGSR DVLPNNRQLY EMVLTYNFHQ PKSGEVTPSC 
       850        860        870        880        890        900 
PLLCELLYES EFDSQLWIIF DQNKRQMGSG DAYPHQYSLK LEKGDYTIRL QIRHEQISDL 
       910        920        930        940        950        960 
ERLKDLPFIV SHRLSNTLSL DIHENHSFAL LGKKKSSNLT LPPKYNQPFF VTSLPDDKIP 
       970        980        990       1000       1010       1020 
KGAGPGCYLA GSLTLSKTEL GKKADVIPVH YYLIPPPTKT KNGSKDKEKD SEKEKDLKEE 
      1030       1040       1050       1060       1070       1080 
FTEALRDLKI QWMTKLDSSD IYNELKETYP NYLPLYVARL HQLDAEKERM KRLNEIVDAA 
      1090       1100       1110       1120       1130       1140 
NAVISHIDQT ALAVYIAMKT DPRPDAATIK NDMDKQKSTL VDALCRKGCA LADHLLHTQA 
      1150       1160       1170       1180       1190       1200 
QDGAISTDAE GKEEEGESPL DSLAETFWET TKWTDLFDNK VLTFAYKHAL VNKMYGRGLK 
      1210       1220       1230       1240    
FATKLVEEKP TKENWKNCIQ LMKLLGWTHC ASFTENWLPI MYPPDYCVF

Isoforms



Sequence View



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Protein Neighborhood

Domains & Features

7 N-termini - 3 C-termini - 2 Cleavages - 2 Substrates

N-termini

C-termini

Cleavages

Substrates