P14384: Carboxypeptidase M

General Information

Protein names	- Carboxypeptidase M - CPM - 3.4.17.12 {ECO:0000269\|PubMed:12457462}
Gene names	CPM
Organism	Homo sapiens
Protease Family	M14.006
Protease ID	M14.006
Chromosome location
UniProt ID	P14384

2 N-termini

3 C-termini

1 Cleavages

9 Substrates

Sequence

        10         20         30         40         50         60
MDFPCLWLGL LLPLVAALDF NYHRQEGMEA FLKTVAQNYS SVTHLHSIGK SVKGRNLWVL
        70         80         90        100        110        120
VVGRFPKEHR IGIPEFKYVA NMHGDETVGR ELLLHLIDYL VTSDGKDPEI TNLINSTRIH
       130        140        150        160        170        180
IMPSMNPDGF EAVKKPDCYY SIGRENYNQY DLNRNFPDAF EYNNVSRQPE TVAVMKWLKT
       190        200        210        220        230        240
ETFVLSANLH GGALVASYPF DNGVQATGAL YSRSLTPDDD VFQYLAHTYA SRNPNMKKGD
       250        260        270        280        290        300
ECKNKMNFPN GVTNGYSWYP LQGGMQDYNY IWAQCFEITL ELSCCKYPRE EKLPSFWNNN
       310        320        330        340        350        360
KASLIEYIKQ VHLGVKGQVF DQNGNPLPNV IVEVQDRKHI CPYRTNKYGE YYLLLLPGSY
       370        380        390        400        410        420
IINVTVPGHD PHITKVIIPE KSQNFSALKK DILLPFQGQL DSIPVSNPSC PMIPLYRNLP
       430        440
DHSAATKPSL FLFLVSLLHI FFK

Isoforms

Sequence View

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

2 N-termini - 3 C-termini - 1 Cleavages - 9 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P14384-18-unknown	LDFNYH...	18		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P14384-424-unknown	AATKPS...	424		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC9866

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...AVKKPD	136	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000449911
...KMNFPN	249	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000446799
...LPDHSA	423	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...LPDHSA	423	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9866

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GPI8_HUMAN	423	DHSA.\|.AATK	inferred from experiment	unknown	MEROPS	Skidgel RA	Tan F et al.:Effect of mutation of two criti... (C13.005)	12457462,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
SDF1_HUMAN	88	ALNK.\|.KRFK	inferred from experiment	unknown	MEROPS	Janowska-Wieczorek A	Marquez-Curtis L et al.:Carboxypeptidase M expressed by... (M14.006)	18292211,
HBA_HUMAN	141	SKYR.\|.R	inferred from experiment	unknown	MEROPS	Erdos EG	Michel B et al.:Removal of Arg141 from the alph... (M14.006)	8635221,
PDYN_HUMAN	179	GFLR.\|.RKYP	inferred from experiment	unknown	MEROPS		Merops CBPM_HUMAN -> PDYN_HUMAN @179
KNG1-Isoform3_HUMAN	352	SPFR.\|.RSSR	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC8308
KNG1_HUMAN	388	SPFR.\|.RSSR	inferred from experiment	unknown	MEROPS		Merops CBPM_HUMAN -> KNG1_HUMAN @388
KNG1-Isoform2_HUMAN	388	SPFR.\|.RSSR	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC8308
EGF-Isoform2_HUMAN	980	WELR.\|.RHAG	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC8311
EGF-Isoform3_HUMAN	981	WELR.\|.RHAG	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC8311
EGF_HUMAN	1022	WELR.\|.RHAG	inferred from experiment	unknown	MEROPS	Li XY	Skidgel RA et al.:Membrane anchoring and release ... (M14.006)	8796265,