P01133: Pro-epidermal growth factor

General Information

Protein names	- Pro-epidermal growth factor - EGF - Epidermal growth factor - Urogastrone
Gene names	EGF
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P01133

4 N-termini

3 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MLLTLIILLP VVSKFSFVSL SAPQHWSCPE GTLAGNGNST CVGPAPFLIF SHGNSIFRID
        70         80         90        100        110        120
TEGTNYEQLV VDAGVSVIMD FHYNEKRIYW VDLERQLLQR VFLNGSRQER VCNIEKNVSG
       130        140        150        160        170        180
MAINWINEEV IWSNQQEGII TVTDMKGNNS HILLSALKYP ANVAVDPVER FIFWSSEVAG
       190        200        210        220        230        240
SLYRADLDGV GVKALLETSE KITAVSLDVL DKRLFWIQYN REGSNSLICS CDYDGGSVHI
       250        260        270        280        290        300
SKHPTQHNLF AMSLFGDRIF YSTWKMKTIW IANKHTGKDM VRINLHSSFV PLGELKVVHP
       310        320        330        340        350        360
LAQPKAEDDT WEPEQKLCKL RKGNCSSTVC GQDLQSHLCM CAEGYALSRD RKYCEDVNEC
       370        380        390        400        410        420
AFWNHGCTLG CKNTPGSYYC TCPVGFVLLP DGKRCHQLVS CPRNVSECSH DCVLTSEGPL
       430        440        450        460        470        480
CFCPEGSVLE RDGKTCSGCS SPDNGGCSQL CVPLSPVSWE CDCFPGYDLQ LDEKSCAASG
       490        500        510        520        530        540
PQPFLLFANS QDIRHMHFDG TDYGTLLSQQ MGMVYALDHD PVENKIYFAH TALKWIERAN
       550        560        570        580        590        600
MDGSQRERLI EEGVDVPEGL AVDWIGRRFY WTDRGKSLIG RSDLNGKRSK IITKENISQP
       610        620        630        640        650        660
RGIAVHPMAK RLFWTDTGIN PRIESSSLQG LGRLVIASSD LIWPSGITID FLTDKLYWCD
       670        680        690        700        710        720
AKQSVIEMAN LDGSKRRRLT QNDVGHPFAV AVFEDYVWFS DWAMPSVMRV NKRTGKDRVR
       730        740        750        760        770        780
LQGSMLKPSS LVVVHPLAKP GADPCLYQNG GCEHICKKRL GTAWCSCREG FMKASDGKTC
       790        800        810        820        830        840
LALDGHQLLA GGEVDLKNQV TPLDILSKTR VSEDNITESQ HMLVAEIMVS DQDDCAPVGC
       850        860        870        880        890        900
SMYARCISEG EDATCQCLKG FAGDGKLCSD IDECEMGVPV CPPASSKCIN TEGGYVCRCS
       910        920        930        940        950        960
EGYQGDGIHC LDIDECQLGE HSCGENASCT NTEGGYTCMC AGRLSEPGLI CPDSTPPPHL
       970        980        990       1000       1010       1020
REDDHHYSVR NSDSECPLSH DGYCLHDGVC MYIEALDKYA CNCVVGYIGE RCQYRDLKWW
      1030       1040       1050       1060       1070       1080
ELRHAGHGQQ QKVIVVAVCV VVLVMLLLLS LWGAHYYRTQ KLLSKNPKNP YEESSRDVRS
      1090       1100       1110       1120       1130       1140
RRPADTEDGM SSCPQPWFVV IKEHQDLKNG GQPVAGEDGQ AADGSMQPTS WRQEPQLCGM
      1150       1160       1170       1180       1190       1200
GTEQGCWIPV SSDKGSCPQV MERSFHMPSY GTQTLEGGVE KPHSLLSANP LWQQRALDPP

HQMELTQ

Isoforms

- Isoform 2 of Pro-epidermal growth factor - Isoform 3 of Pro-epidermal growth factor

Sequence View

        10         20         30         40         50         60
MLLTLIILLP VVSKFSFVSL SAPQHWSCPE GTLAGNGNST CVGPAPFLIF SHGNSIFRID
        70         80         90        100        110        120
TEGTNYEQLV VDAGVSVIMD FHYNEKRIYW VDLERQLLQR VFLNGSRQER VCNIEKNVSG
       130        140        150        160        170        180
MAINWINEEV IWSNQQEGII TVTDMKGNNS HILLSALKYP ANVAVDPVER FIFWSSEVAG
       190        200        210        220        230        240
SLYRADLDGV GVKALLETSE KITAVSLDVL DKRLFWIQYN REGSNSLICS CDYDGGSVHI
       250        260        270        280        290        300
SKHPTQHNLF AMSLFGDRIF YSTWKMKTIW IANKHTGKDM VRINLHSSFV PLGELKVVHP
       310        320        330        340        350        360
LAQPKAEDDT WEPEQKLCKL RKGNCSSTVC GQDLQSHLCM CAEGYALSRD RKYCEDVNEC
       370        380        390        400        410        420
AFWNHGCTLG CKNTPGSYYC TCPVGFVLLP DGKRCHQLVS CPRNVSECSH DCVLTSEGPL
       430        440        450        460        470        480
CFCPEGSVLE RDGKTCSGCS SPDNGGCSQL CVPLSPVSWE CDCFPGYDLQ LDEKSCAASG
       490        500        510        520        530        540
PQPFLLFANS QDIRHMHFDG TDYGTLLSQQ MGMVYALDHD PVENKIYFAH TALKWIERAN
       550        560        570        580        590        600
MDGSQRERLI EEGVDVPEGL AVDWIGRRFY WTDRGKSLIG RSDLNGKRSK IITKENISQP
       610        620        630        640        650        660
RGIAVHPMAK RLFWTDTGIN PRIESSSLQG LGRLVIASSD LIWPSGITID FLTDKLYWCD
       670        680        690        700        710        720
AKQSVIEMAN LDGSKRRRLT QNDVGHPFAV AVFEDYVWFS DWAMPSVMRV NKRTGKDRVR
       730        740        750        760        770        780
LQGSMLKPSS LVVVHPLAKP GADPCLYQNG GCEHICKKRL GTAWCSCREG FMKASDGKTC
       790        800        810        820        830        840
LALDGHQLLA GGEVDLKNQV TPLDILSKTR VSEDNITESQ HMLVAEIMVS DQDDCAPVGC
       850        860        870        880        890        900
SMYARCISEG EDATCQCLKG FAGDGKLCSD IDECEMGVPV CPPASSKCIN TEGGYVCRCS
       910        920        930        940        950        960
EGYQGDGIHC LDIDECQLGE HSCGENASCT NTEGGYTCMC AGRLSEPGLI CPDSTPPPHL
       970        980        990       1000       1010       1020
REDDHHYSVR NSDSECPLSH DGYCLHDGVC MYIEALDKYA CNCVVGYIGE RCQYRDLKWW
      1030       1040       1050       1060       1070       1080
ELRHAGHGQQ QKVIVVAVCV VVLVMLLLLS LWGAHYYRTQ KLLSKNPKNP YEESSRDVRS
      1090       1100       1110       1120       1130       1140
RRPADTEDGM SSCPQPWFVV IKEHQDLKNG GQPVAGEDGQ AADGSMQPTS WRQEPQLCGM
      1150       1160       1170       1180       1190       1200
GTEQGCWIPV SSDKGSCPQV MERSFHMPSY GTQTLEGGVE KPHSLLSANP LWQQRALDPP

HQMELTQ         10         20         30         40         50         60
MLLTLIILLP VVSKFSFVSL SAPQHWSCPE GTLAGNGNST CVGPAPFLIF SHGNSIFRID
        70         80         90        100        110        120
TEGTNYEQLV VDAGVSVIMD FHYNEKRIYW VDLERQLLQR VFLNGSRQER VCNIEKNVSG
       130        140        150        160        170        180
MAINWINEEV IWSNQQEGII TVTDMKGNNS HILLSALKYP ANVAVDPVER FIFWSSEVAG
       190        200        210        220        230        240
SLYRADLDGV GVKALLETSE KITAVSLDVL DKRLFWIQYN REGSNSLICS CDYDGGSVHI
       250        260        270        280        290        300
SKHPTQHNLF AMSLFGDRIF YSTWKMKTIW IANKHTGKDM VRINLHSSFV PLGELKVVHP
       310        320        330        340        350        360
LAQPKAEDDT WEPEQKLCKL RKGNCSSTVC GQDLQSHLCM CAEGYALSRD RKYCEDVNEC
       370        380        390        400        410        420
AFWNHGCTLG CKNTPGSYYC TCPVGFVLLP DGKRCHQLVS CPRNVSECSH DCVLTSEGPL
       430        440        450        460        470        480
CFCPEGSVLE RDGKTCSGCS SPDNGGCSQL CVPLSPVSWE CDCFPGYDLQ LDEKSCAASG
       490        500        510        520        530        540
PQPFLLFANS QDIRHMHFDG TDYGTLLSQQ MGMVYALDHD PVENKIYFAH TALKWIERAN
       550        560        570        580        590        600
MDGSQRERLI EEGVDVPEGL AVDWIGRRFY WTDRGKSLIG RSDLNGKRSK IITKENISQP
       610        620        630        640        650        660
RGIAVHPMAK RLFWTDTGIN PRIESSSLQG LGRLVIASSD LIWPSGITID FLTDKLYWCD
       670        680        690        700        710        720
AKQSVIEMAN LDGSKRRRLT QNDVGHPFAV AVFEDYVWFS DWAMPSVMRV NKRTGKDRVR
       730        740        750        760        770        780
LQGSMLKPSS LVVVHPLAKP GADPCLYQNG GCEHICKKRL GTAWCSCREG FMKASDGKTC
       790        800        810        820        830        840
LALDGHQLLA GGEVDLKNQV TPLDILSKTR VSEDNITESQ HMLVAEIMVS DQDDCAPVGC
       850        860        870        880        890        900
SMYARCISEG EDATCQCLKG FAGDGKLCSD IDECEMGVPV CPPASSKCIN TEGGYVCRCS
       910        920        930        940        950        960
EGYQGDGIHC LDIDECQLGE HSCGENASCT NTEGGYTCMC AGRLSEPGLI CPDSTPPPHL
       970        980        990       1000       1010       1020
REDDHHYSVR NSDSECPLSH DGYCLHDGVC MYIEALDKYA CNCVVGYIGE RCQYRDLKWW
      1030       1040       1050       1060       1070       1080
ELRHAGHGQQ QKVIVVAVCV VVLVMLLLLS LWGAHYYRTQ KLLSKNPKNP YEESSRDVRS
      1090       1100       1110       1120       1130       1140
RRPADTEDGM SSCPQPWFVV IKEHQDLKNG GQPVAGEDGQ AADGSMQPTS WRQEPQLCGM
      1150       1160       1170       1180       1190       1200
GTEQGCWIPV SSDKGSCPQV MERSFHMPSY GTQTLEGGVE KPHSLLSANP LWQQRALDPP

HQMELTQ

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
P01133-1-unknown	MLLTLI...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt73726
P01133-1-unknown	MLLTLI...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt73727
P01133-23-unknown	PQHWSC...	23	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P01133-23-unknown	PQHWSC...	23	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt113273
P01133-23-unknown	PQHWSC...	23	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt113274
P01133-971-unknown	NSDSEC...	971	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P01133-971-unknown	NSDSEC...	971	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt116428
P01133-971-unknown	NSDSEC...	971	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt116427
P01133-1023-unknown	RHAGHG...	1023	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8311
P01133-1023-unknown	RHAGHG...	1023	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt157111
P01133-1023-unknown	RHAGHG...	1023	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt157113

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...KWWELR	1022	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8311
...KWWELR	1022	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt140611
...KWWELR	1022	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt140613
...WWELRH	1023	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...WWELRH	1023	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt93619
...WWELRH	1023	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt93618
...MELTQ	1207	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...MELTQ	1207	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt69344
...MELTQ	1207	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt69345

TopFIND

P01133: Pro-epidermal growth factor

General Information

4

N-termini

3

C-termini

1

Cleavages

0

Substrates

Sequence

Isoforms

Filter Information:

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Evidence Codes:

Methodology:

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Protein Neighborhood

Domains & Features

4 N-termini - 3 C-termini - 1 Cleavages - 0 Substrates

N-termini

C-termini

Cleavages

Substrates