Q9UIQ6: Leucyl-cystinyl aminopeptidase

General Information

Protein names	- Leucyl-cystinyl aminopeptidase - Cystinyl aminopeptidase - 3.4.11.3 - Insulin-regulated membrane aminopeptidase - Insulin-responsive aminopeptidase - IRAP - Oxytocinase - OTase - Placental leucine aminopeptidase - P-LAP - Leucyl-cystinyl aminopeptidase, pregnancy serum form
Gene names	LNPEP
Organism	Homo sapiens
Protease Family	M01.011
Protease ID	M01.011
Chromosome location
UniProt ID	Q9UIQ6

4 N-termini

1 C-termini

0 Cleavages

8 Substrates

Sequence

Isoforms

- Isoform 2 of Leucyl-cystinyl aminopeptidase - Isoform 3 of Leucyl-cystinyl aminopeptidase

Sequence View

        10         20         30         40         50         60
MEPFTNDRLQ LPRNMIENSM FEEEPDVVDL AKEPCLHPLE PDEVEYEPRG SRLLVRGLGE
        70         80         90        100        110        120
HEMEEDEEDY ESSAKLLGMS FMNRSSGLRN SATGYRQSPD GACSVPSART MVVCAFVIVV
       130        140        150        160        170        180
AVSVIMVIYL LPRCTFTKEG CHKKNQSIGL IQPFATNGKL FPWAQIRLPT AVVPLRYELS
       190        200        210        220        230        240
LHPNLTSMTF RGSVTISVQA LQVTWNIILH STGHNISRVT FMSAVSSQEK QAEILEYAYH
       250        260        270        280        290        300
GQIAIVAPEA LLAGHNYTLK IEYSANISSS YYGFYGFSYT DESNEKKYFA ATQFEPLAAR
       310        320        330        340        350        360
SAFPCFDEPA FKATFIIKII RDEQYTALSN MPKKSSVVLD DGLVQDEFSE SVKMSTYLVA
       370        380        390        400        410        420
FIVGEMKNLS QDVNGTLVSI YAVPEKIGQV HYALETTVKL LEFFQNYFEI QYPLKKLDLV
       430        440        450        460        470        480
AIPDFEAGAM ENWGLLTFRE ETLLYDSNTS SMADRKLVTK IIAHELAHQW FGNLVTMKWW
       490        500        510        520        530        540
NDLWLNEGFA TFMEYFSLEK IFKELSSYED FLDARFKTMK KDSLNSSHPI SSSVQSSEQI
       550        560        570        580        590        600
EEMFDSLSYF KGSSLLLMLK TYLSEDVFQH AVVLYLHNHS YASIQSDDLW DSFNEVTNQT
       610        620        630        640        650        660
LDVKRMMKTW TLQKGFPLVT VQKKGKELFI QQERFFLNMK PEIQPSDTSY LWHIPLSYVT
       670        680        690        700        710        720
EGRNYSKYQS VSLLDKKSGV INLTEEVLWV KVNINMNGYY IVHYADDDWE ALIHQLKINP
       730        740        750        760        770        780
YVLSDKDRAN LINNIFELAG LGKVPLKRAF DLINYLGNEN HTAPITEALF QTDLIYNLLE
       790        800        810        820        830        840
KLGYMDLASR LVTRVFKLLQ NQIQQQTWTD EGTPSMRELR SALLEFACTH NLGNCSTTAM
       850        860        870        880        890        900
KLFDDWMASN GTQSLPTDVM TTVFKVGAKT DKGWSFLLGK YISIGSEAEK NKILEALASS
       910        920        930        940        950        960
EDVRKLYWLM KSSLNGDNFR TQKLSFIIRT VGRHFPGHLL AWDFVKENWN KLVQKFPLGS
       970        980        990       1000       1010       1020
YTIQNIVAGS TYLFSTKTHL SEVQAFFENQ SEATFRLRCV QEALEVIQLN IQWMEKNLKS

LTWWL         10         20         30         40         50         60
MEPFTNDRLQ LPRNMIENSM FEEEPDVVDL AKEPCLHPLE PDEVEYEPRG SRLLVRGLGE
        70         80         90        100        110        120
HEMEEDEEDY ESSAKLLGMS FMNRSSGLRN SATGYRQSPD GACSVPSART MVVCAFVIVV
       130        140        150        160        170        180
AVSVIMVIYL LPRCTFTKEG CHKKNQSIGL IQPFATNGKL FPWAQIRLPT AVVPLRYELS
       190        200        210        220        230        240
LHPNLTSMTF RGSVTISVQA LQVTWNIILH STGHNISRVT FMSAVSSQEK QAEILEYAYH
       250        260        270        280        290        300
GQIAIVAPEA LLAGHNYTLK IEYSANISSS YYGFYGFSYT DESNEKKYFA ATQFEPLAAR
       310        320        330        340        350        360
SAFPCFDEPA FKATFIIKII RDEQYTALSN MPKKSSVVLD DGLVQDEFSE SVKMSTYLVA
       370        380        390        400        410        420
FIVGEMKNLS QDVNGTLVSI YAVPEKIGQV HYALETTVKL LEFFQNYFEI QYPLKKLDLV
       430        440        450        460        470        480
AIPDFEAGAM ENWGLLTFRE ETLLYDSNTS SMADRKLVTK IIAHELAHQW FGNLVTMKWW
       490        500        510        520        530        540
NDLWLNEGFA TFMEYFSLEK IFKELSSYED FLDARFKTMK KDSLNSSHPI SSSVQSSEQI
       550        560        570        580        590        600
EEMFDSLSYF KGSSLLLMLK TYLSEDVFQH AVVLYLHNHS YASIQSDDLW DSFNEVTNQT
       610        620        630        640        650        660
LDVKRMMKTW TLQKGFPLVT VQKKGKELFI QQERFFLNMK PEIQPSDTSY LWHIPLSYVT
       670        680        690        700        710        720
EGRNYSKYQS VSLLDKKSGV INLTEEVLWV KVNINMNGYY IVHYADDDWE ALIHQLKINP
       730        740        750        760        770        780
YVLSDKDRAN LINNIFELAG LGKVPLKRAF DLINYLGNEN HTAPITEALF QTDLIYNLLE
       790        800        810        820        830        840
KLGYMDLASR LVTRVFKLLQ NQIQQQTWTD EGTPSMRELR SALLEFACTH NLGNCSTTAM
       850        860        870        880        890        900
KLFDDWMASN GTQSLPTDVM TTVFKVGAKT DKGWSFLLGK YISIGSEAEK NKILEALASS
       910        920        930        940        950        960
EDVRKLYWLM KSSLNGDNFR TQKLSFIIRT VGRHFPGHLL AWDFVKENWN KLVQKFPLGS
       970        980        990       1000       1010       1020
YTIQNIVAGS TYLFSTKTHL SEVQAFFENQ SEATFRLRCV QEALEVIQLN IQWMEKNLKS

LTWWL

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

4 N-termini - 1 C-termini - 0 Cleavages - 8 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q9UIQ6-1-Acetylation	MEPFTN...	1	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9UIQ6-1-Acetylation	MEPFTN...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
Q9UIQ6-1-Acetylation	MEPFTN...	1	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
Q9UIQ6-1-Acetylation	MEPFTN...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q9UIQ6-15-unknown	MIENSM...	15		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt79429
Q9UIQ6-20-unknown	MFEEEP...	20		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt79430
Q9UIQ6-20-unknown	MFEEEP...	20		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt99814
Q9UIQ6-155-unknown	ATNGKL...	155		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9UIQ6-155-unknown	ATNGKL...	155		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt115966
Q9UIQ6-155-unknown	ATNGKL...	155		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt115967

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...LTWWL	1025	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...LTWWL	1025	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt75048
...LTWWL	1025	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt75047

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
NEU1_HUMAN	20	SACY.\|.YIQN	inferred from experiment	unknown	MEROPS		Merops LCAP_HUMAN -> NEU1_HUMAN @20
NEU2_HUMAN	20	SACY.\|.YFQN	inferred from experiment	unknown	MEROPS	Keller SR	Wallis MG et al.:Vasopressin is a physiological ... (M01.011)	17684103,
ANGT_HUMAN	35	GDRV.\|.VYIH	inferred from experiment	unknown	MEROPS		Merops LCAP_HUMAN -> ANGT_HUMAN @35
ANGT_HUMAN	36	DRVY.\|.YIHP	inferred from experiment	unknown	MEROPS		Merops LCAP_HUMAN -> ANGT_HUMAN @36
PDYN_HUMAN	175	KRYG.\|.GGFL	inferred from experiment	unknown	MEROPS	Albiston AL	Ye S et al.:Identification of modulating re... (M01.011)	18523486,
KNG1-Isoform3_HUMAN	344	LMKR.\|.RPPG	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC16706
KNG1_HUMAN	380	LMKR.\|.RPPG	inferred from experiment	unknown	MEROPS		Merops LCAP_HUMAN -> KNG1_HUMAN @380
KNG1-Isoform2_HUMAN	380	LMKR.\|.RPPG	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC16706