P09668: Pro-cathepsin H

General Information

Protein names	- Pro-cathepsin H - Cathepsin H mini chain - Cathepsin H - 3.4.22.16 - Cathepsin H heavy chain - Cathepsin H light chain
Gene names	CTSH
Organism	Homo sapiens
Protease Family	C01.040
Protease ID	C01.040
Chromosome location
UniProt ID	P09668

3 N-termini

3 C-termini

0 Cleavages

10 Substrates

Sequence

        10         20         30         40         50         60
MWATLPLLCA GAWLLGVPVC GAAELCVNSL EKFHFKSWMS KHRKTYSTEE YHHRLQTFAS
        70         80         90        100        110        120
NWRKINAHNN GNHTFKMALN QFSDMSFAEI KHKYLWSEPQ NCSATKSNYL RGTGPYPPSV
       130        140        150        160        170        180
DWRKKGNFVS PVKNQGACGS CWTFSTTGAL ESAIAIATGK MLSLAEQQLV DCAQDFNNHG
       190        200        210        220        230        240
CQGGLPSQAF EYILYNKGIM GEDTYPYQGK DGYCKFQPGK AIGFVKDVAN ITIYDEEAMV
       250        260        270        280        290        300
EAVALYNPVS FAFEVTQDFM MYRTGIYSST SCHKTPDKVN HAVLAVGYGE KNGIPYWIVK
       310        320        330
NSWGPQWGMN GYFLIERGKN MCGLAACASY PIPLV

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

3 N-termini - 3 C-termini - 0 Cleavages - 10 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
P09668-77-unknown	MALNQF...	77	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000435329
P09668-116-unknown	YPPSVD...	116	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P09668-293-unknown	GIPYWI...	293	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...PYQGKD	210	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000435329
...YGEKNG	292	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...PIPLV	335	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
OSTCN_HUMAN	58	WLGA.\|.APVP	inferred from experiment	unknown	MEROPS	Price PA	Baumgrass R et al.:Identification of peptide fragm... (C01.060)	9076588,
PSPB_HUMAN	187	LQAR.\|.RPGP	inferred from experiment	unknown	MEROPS	Weaver TE	Ueno T et al.:Processing of pulmonary surfact... (C01.040)	14766755,
PDYN_HUMAN	211	GFLR.\|.RRIR	inferred from experiment	unknown	MEROPS	Popovic T	Brguljan PM et al.:Human brain cathepsin H as a ne... (C01.040)	15127951,
PSPB_HUMAN	279	CSMD.\|.DDSA	inferred from experiment	unknown	MEROPS	Weaver TE	Ueno T et al.:Processing of pulmonary surfact... (C01.040)	14766755,
PSPB_HUMAN	316	EQAI.\|.IPQA	inferred from experiment	unknown	MEROPS	Weaver TE	Ueno T et al.:Processing of pulmonary surfact... (C01.040)	14766755,
KNG1-Isoform3_HUMAN	349	PGFS.\|.SPFR	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC4963
PSPB_HUMAN	349	LTLV.\|.VPRG	inferred from experiment	unknown	MEROPS	Weaver TE	Ueno T et al.:Processing of pulmonary surfact... (C01.040)	14766755,
PSPB_HUMAN	377	CIHS.\|.SPDL	inferred from experiment	unknown	MEROPS	Weaver TE	Ueno T et al.:Processing of pulmonary surfact... (C01.040)	14766755,
KNG1_HUMAN	385	PGFS.\|.SPFR	inferred from experiment	unknown	MEROPS	Popovic T	Brguljan PM et al.:Human brain cathepsin H as a ne... (C01.040)	15127951,
KNG1-Isoform2_HUMAN	385	PGFS.\|.SPFR	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC4963