TopFIND 4.0

P02818: Osteocalcin

General Information

Protein names	- Osteocalcin - Bone Gla protein - BGP - Gamma-carboxyglutamic acid-containing protein
Gene names	BGLAP
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P02818

5

N-termini

5

C-termini

8

Cleavages

0

Substrates

Sequence

10 20 30 40 50 60
MRALTLLALL ALAALCIAGQ AGAKPSGAES SKGAAFVSKQ EGSEVVKRPR RYLYQWLGAP
70 80 90 100
VPYPDPLEPR REVCELNPDC DELADHIGFQ EAYRRFYGPV

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

5 N-termini - 5 C-termini - 8 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P02818-24-unknown	KPSGAE...	24		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P02818-52-unknown	YLYQWL...	52		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P02818-59-unknown	APVPYP...	59		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7179
P02818-59-unknown	APVPYP...	59		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3360
P02818-59-unknown	APVPYP...	59		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC4967
P02818-59-unknown	APVPYP...	59		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5365
P02818-93-unknown	YRRFYG...	93		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC4367
P02818-95-unknown	RFYGPV...	95		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC27474
P02818-95-unknown	RFYGPV...	95		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5366

C-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
	...YQWLGA	58	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7179
	...YQWLGA	58	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3360
	...YQWLGA	58	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC4967
	...YQWLGA	58	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5365
	...GFQEAY	92	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC4367
	...QEAYRR	94	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC27474
	...QEAYRR	94	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5366
	...EAYRRF	95	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3361
	...FYGPV	100	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATS_HUMAN	58	WLGA.\|.APVP	inferred from experiment	unknown	MEROPS	Price PA	Baumgrass R et al.:Identification of peptide fragm... (C01.060)	9076588,
CATB_HUMAN	58	WLGA.\|.APVP	inferred from experiment	unknown	MEROPS	Price PA	Baumgrass R et al.:Identification of peptide fragm... (C01.060)	9076588,
CATH_HUMAN	58	WLGA.\|.APVP	inferred from experiment	unknown	MEROPS	Price PA	Baumgrass R et al.:Identification of peptide fragm... (C01.060)	9076588,
CATL1_HUMAN	58	WLGA.\|.APVP	inferred from experiment	unknown	MEROPS	Price PA	Baumgrass R et al.:Identification of peptide fragm... (C01.060)	9076588,
CATD_HUMAN	92	QEAY.\|.YRRF	inferred from experiment	unknown	MEROPS	Price PA	Baumgrass R et al.:Identification of peptide fragm... (C01.060)	9076588,
PLMN_HUMAN	94	AYRR.\|.RFYG	inferred from experiment	unknown	MEROPS	Traynelis SF	Yuan H et al.:The serine protease plasmin cle... (S01.233)	19240037,
CATL1_HUMAN	94	AYRR.\|.RFYG	inferred from experiment	unknown	MEROPS	Price PA	Baumgrass R et al.:Identification of peptide fragm... (C01.060)	9076588,
CATB_HUMAN	95	YRRF.\|.FYGP	inferred from experiment	unknown	MEROPS	Price PA	Baumgrass R et al.:Identification of peptide fragm... (C01.060)	9076588,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)