P18827: Syndecan-1

General Information

Protein names	- Syndecan-1 - SYND1 - CD138
Gene names	SDC1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P18827

8 N-termini

8 C-termini

6 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MRRAALWLWL CALALSLQPA LPQIVATNLP PEDQDGSGDD SDNFSGSGAG ALQDITLSQQ
        70         80         90        100        110        120
TPSTWKDTQL LTAIPTSPEP TGLEATAAST STLPAGEGPK EGEAVVLPEV EPGLTAREQE
       130        140        150        160        170        180
ATPRPRETTQ LPTTHLASTT TATTAQEPAT SHPHRDMQPG HHETSTPAGP SQADLHTPHT
       190        200        210        220        230        240
EDGGPSATER AAEDGASSQL PAAEGSGEQD FTFETSGENT AVVAVEPDRR NQSPVDQGAT
       250        260        270        280        290        300
GASQGLLDRK EVLGGVIAGG LVGLIFAVCL VGFMLYRMKK KDEGSYSLEE PKQANGGAYQ
       310
KPTKQEEFYA

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

8 N-termini - 8 C-termini - 6 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P18827-23-unknown	QIVATN...	23	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P18827-83-unknown	LEATAA...	83	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC21585
P18827-97-unknown	EGPKEG...	97	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18822
P18827-214-unknown	ETSGEN...	214	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18823
P18827-215-unknown	TSGENT...	215	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18824
P18827-217-unknown	GENTAV...	217	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18825
P18827-217-unknown	GENTAV...	217	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P18827-217-unknown	GENTAV...	217	inferred from similarity	unknown	UniProtKB		inferred from uniprot (by similarity)
P18827-221-	AVVAVE...	221		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P18827-246-unknown	LLDRKE...	246	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC21586

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...PEPTGL	82	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21585
...TLPAGE	96	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18822
...AEGSGE	207	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000400773
...QDFTFE	213	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18823
...DFTFET	214	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18824
...TFETSG	216	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18825
...GASQGL	245	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21586
...EEFYA	310	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MMP14_HUMAN	82	PTGL.\|.LEAT	inferred from experiment	unknown	MEROPS	Sato H	Li Y et al.:Cleavage of lumican by membrane... (M10.014)	15466200,
MEP1B_HUMAN	96	PAGE.\|.EGPK	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	213	FTFE.\|.ETSG	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	214	TFET.\|.TSGE	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	216	ETSG.\|.GENT	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MMP14_HUMAN	245	SQGL.\|.LLDR	inferred from experiment	unknown	MEROPS	Sato H	Endo K et al.:Cleavage of syndecan-1 by membr... (M10.014)	12904296,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)