P21980: Protein-glutamine gamma-glutamyltransferase 2
Protein names | - Protein-glutamine gamma-glutamyltransferase 2 - 2.3.2.13 - Tissue transglutaminase - Transglutaminase C - TG(C) - TGC - TGase C - Transglutaminase H - TGase H - Transglutaminase-2 - TGase-2 |
---|---|
Gene names | TGM2 |
Organism | Homo sapiens |
Protease Family | |
Protease ID | |
Chromosome location | |
UniProt ID | P21980 |
21
N-termini
6
C-termini
7
Cleavages
0
Substrates
Sequence
10 20 30 40 50 60
MAEELVLERC DLELETNGRD HHTADLCREK LVVRRGQPFW LTLHFEGRNY EASVDSLTFS
70 80 90 100 110 120
VVTGPAPSQE AGTKARFPLR DAVEEGDWTA TVVDQQDCTL SLQLTTPANA PIGLYRLSLE
130 140 150 160 170 180
ASTGYQGSSF VLGHFILLFN AWCPADAVYL DSEEERQEYV LTQQGFIYQG SAKFIKNIPW
190 200 210 220 230 240
NFGQFEDGIL DICLILLDVN PKFLKNAGRD CSRRSSPVYV GRVVSGMVNC NDDQGVLLGR
250 260 270 280 290 300
WDNNYGDGVS PMSWIGSVDI LRRWKNHGCQ RVKYGQCWVF AAVACTVLRC LGIPTRVVTN
310 320 330 340 350 360
YNSAHDQNSN LLIEYFRNEF GEIQGDKSEM IWNFHCWVES WMTRPDLQPG YEGWQALDPT
370 380 390 400 410 420
PQEKSEGTYC CGPVPVRAIK EGDLSTKYDA PFVFAEVNAD VVDWIQQDDG SVHKSINRSL
430 440 450 460 470 480
IVGLKISTKS VGRDEREDIT HTYKYPEGSS EEREAFTRAN HLNKLAEKEE TGMAMRIRVG
490 500 510 520 530 540
QSMNMGSDFD VFAHITNNTA EEYVCRLLLC ARTVSYNGIL GPECGTKYLL NLNLEPFSEK
550 560 570 580 590 600
SVPLCILYEK YRDCLTESNL IKVRALLVEP VINSYLLAER DLYLENPEIK IRILGEPKQK
610 620 630 640 650 660
RKLVAEVSLQ NPLPVALEGC TFTVEGAGLT EEQKTVEIPD PVEAGEEVKV RMDLLPLHMG
670 680
LHKLVVNFES DKLKAVKGFR NVIIGPA
Isoforms
- Isoform 2 of Protein-glutamine gamma-glutamyltransferase 2 - Isoform 3 of Protein-glutamine gamma-glutamyltransferase 2Sequence View
10 20 30 40 50 60
MAEELVLERC DLELETNGRD HHTADLCREK LVVRRGQPFW LTLHFEGRNY EASVDSLTFS
70 80 90 100 110 120
VVTGPAPSQE AGTKARFPLR DAVEEGDWTA TVVDQQDCTL SLQLTTPANA PIGLYRLSLE
130 140 150 160 170 180
ASTGYQGSSF VLGHFILLFN AWCPADAVYL DSEEERQEYV LTQQGFIYQG SAKFIKNIPW
190 200 210 220 230 240
NFGQFEDGIL DICLILLDVN PKFLKNAGRD CSRRSSPVYV GRVVSGMVNC NDDQGVLLGR
250 260 270 280 290 300
WDNNYGDGVS PMSWIGSVDI LRRWKNHGCQ RVKYGQCWVF AAVACTVLRC LGIPTRVVTN
310 320 330 340 350 360
YNSAHDQNSN LLIEYFRNEF GEIQGDKSEM IWNFHCWVES WMTRPDLQPG YEGWQALDPT
370 380 390 400 410 420
PQEKSEGTYC CGPVPVRAIK EGDLSTKYDA PFVFAEVNAD VVDWIQQDDG SVHKSINRSL
430 440 450 460 470 480
IVGLKISTKS VGRDEREDIT HTYKYPEGSS EEREAFTRAN HLNKLAEKEE TGMAMRIRVG
490 500 510 520 530 540
QSMNMGSDFD VFAHITNNTA EEYVCRLLLC ARTVSYNGIL GPECGTKYLL NLNLEPFSEK
550 560 570 580 590 600
SVPLCILYEK YRDCLTESNL IKVRALLVEP VINSYLLAER DLYLENPEIK IRILGEPKQK
610 620 630 640 650 660
RKLVAEVSLQ NPLPVALEGC TFTVEGAGLT EEQKTVEIPD PVEAGEEVKV RMDLLPLHMG
670 680
LHKLVVNFES DKLKAVKGFR NVIIGPA
10 20 30 40 50 60
MAEELVLERC DLELETNGRD HHTADLCREK LVVRRGQPFW LTLHFEGRNY EASVDSLTFS
70 80 90 100 110 120
VVTGPAPSQE AGTKARFPLR DAVEEGDWTA TVVDQQDCTL SLQLTTPANA PIGLYRLSLE
130 140 150 160 170 180
ASTGYQGSSF VLGHFILLFN AWCPADAVYL DSEEERQEYV LTQQGFIYQG SAKFIKNIPW
190 200 210 220 230 240
NFGQFEDGIL DICLILLDVN PKFLKNAGRD CSRRSSPVYV GRVVSGMVNC NDDQGVLLGR
250 260 270 280 290 300
WDNNYGDGVS PMSWIGSVDI LRRWKNHGCQ RVKYGQCWVF AAVACTVLRC LGIPTRVVTN
310 320 330 340 350 360
YNSAHDQNSN LLIEYFRNEF GEIQGDKSEM IWNFHCWVES WMTRPDLQPG YEGWQALDPT
370 380 390 400 410 420
PQEKSEGTYC CGPVPVRAIK EGDLSTKYDA PFVFAEVNAD VVDWIQQDDG SVHKSINRSL
430 440 450 460 470 480
IVGLKISTKS VGRDEREDIT HTYKYPEGSS EEREAFTRAN HLNKLAEKEE TGMAMRIRVG
490 500 510 520 530 540
QSMNMGSDFD VFAHITNNTA EEYVCRLLLC ARTVSYNGIL GPECGTKYLL NLNLEPFSEK
550 560 570 580 590 600
SVPLCILYEK YRDCLTESNL IKVRALLVEP VINSYLLAER DLYLENPEIK IRILGEPKQK
610 620 630 640 650 660
RKLVAEVSLQ NPLPVALEGC TFTVEGAGLT EEQKTVEIPD PVEAGEEVKV RMDLLPLHMG
670 680
LHKLVVNFES DKLKAVKGFR NVIIGPA
Protein Neighborhood
Domains & Features
21 N-termini - 6 C-termini - 7 Cleavages - 0 Substrates
N-termini
Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
---|---|---|---|---|---|---|---|---|---|
P21980-1-acetylation | MAEELV... | 1 | acetylation- | COFRADIC | Gevaert K. | Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates... | 20526345 | ||
P21980-1-acetylation | MAEELV... | 1 | acetylation- | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt178978 | ||
P21980-1-acetylation | MAEELV... | 1 | acetylation- | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt178979 | ||
P21980-2-unknown | MAEELV... | 1 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
P21980-1-unknown | MAEELV... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt92045 | |||
P21980-1-unknown | MAEELV... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt92046 | |||
P21980-2-Acetylation | AEELVL... | 2 | acetylation- | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | ||
P21980-2-Acetylation | AEELVL... | 2 | acetylation- | COFRADIC | Gevaert K. | Van Damme P et al.: Complementary positional proteomics for screening substrates... | 20526345 | ||
P21980-2-Acetylation | AEELVL... | 2 | acetylation- | COFRADIC | Gevaert K. | Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates... | 20526345 | ||
P21980-2-Acetylation | AEELVL... | 2 | acetylation- | N-TAILS | Overall Laboratory | Lange_Huesgen_et_al-RBC | |||
P21980-2-Acetylation | AEELVL... | 2 | acetylation- | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt111077 | ||
P21980-2-Acetylation | AEELVL... | 2 | acetylation- | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt111078 | ||
P21980-58- | TFSVVT... | 58 | N-TAILS | Overall Laboratory | Lange_Huesgen_et_al-RBC | ||||
P21980-58-unknown | TFSVVT... | 58 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt182541 | |||
P21980-58-unknown | TFSVVT... | 58 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt182542 | |||
P21980-60- | SVVTGP... | 60 | N-TAILS | Overall Laboratory | Lange_Huesgen_et_al-RBC | ||||
P21980-60-unknown | SVVTGP... | 60 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt182544 | |||
P21980-60-unknown | SVVTGP... | 60 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt182545 | |||
P21980-223-acetylation | VVSGMV... | 223 | acetylation- | N-TAILS | Overall Laboratory | Lange_Huesgen_et_al-RBC | |||
P21980-223-acetylation | VVSGMV... | 223 | acetylation- | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt182532 | ||
P21980-223-acetylation | VVSGMV... | 223 | acetylation- | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt182533 | ||
P21980-303- | SAHDQN... | 303 | N-TAILS | Overall Laboratory | Lange_Huesgen_et_al-RBC | ||||
P21980-303-unknown | SAHDQN... | 303 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt182535 | |||
P21980-309- | SNLLIE... | 309 | N-TAILS | Overall Laboratory | Lange_Huesgen_et_al-RBC | ||||
P21980-309-unknown | SNLLIE... | 309 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt182537 | |||
P21980-327-unknown | KSEMIW... | 327 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC11335 | |||
P21980-327-unknown | KSEMIW... | 327 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt150467 | |||
P21980-376-unknown | VRAIKE... | 376 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC22830 | |||
P21980-376-unknown | VRAIKE... | 376 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC21587 | |||
P21980-376-unknown | VRAIKE... | 376 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt151530 | |||
P21980-404- | WIQQDD... | 404 | Subtiligase Based Positive Selection | Wells | apoptosis_U266_bortezomib_induced | 23264352 | |||
P21980-404-unknown | WIQQDD... | 404 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt178082 | |||
P21980-459-unknown | ANHLNK... | 459 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC22832 | |||
P21980-459-unknown | ANHLNK... | 459 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC21589 | |||
P21980-459-unknown | ANHLNK... | 459 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt152892 | |||
P21980-462-unknown | LNKLAE... | 462 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC22834 | |||
P21980-462-unknown | LNKLAE... | 462 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC21591 | |||
P21980-462-unknown | LNKLAE... | 462 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt152935 | |||
P21980-565- | ALLVEP... | 565 | N-TAILS | Overall Laboratory | Lange_Huesgen_et_al-RBC | ||||
P21980-565-acetylation | ALLVEP... | 565 | acetylation- | N-TAILS | Overall Laboratory | Lange_Huesgen_et_al-RBC |
C-termini
Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
...EIQGDK | 326 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC11335 | |||
...EIQGDK | 326 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt133862 | |||
...CGPVPV | 375 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC22830 | |||
...CGPVPV | 375 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC21587 | |||
...CGPVPV | 375 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt134935 | |||
...EAFTRA | 458 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC22832 | |||
...EAFTRA | 458 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC21589 | |||
...EAFTRA | 458 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt136317 | |||
...TRANHL | 461 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC22834 | |||
...TRANHL | 461 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC21591 | |||
...TRANHL | 461 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt136361 | |||
...IIGPA | 687 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
...IIGPA | 687 | COFRADIC | Gevaert K. | Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates... | 20526345, | |||
...IIGPA | 687 | COFRADIC | Gevaert K. | Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates... | 20526345, |
Cleavages
Substrates
Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
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