Q99497: Protein/nucleic acid deglycase DJ-1 {ECO:0000305|PubMed:25416785, ECO:0000305|PubMed:28596309}

General Information

Protein names	- Protein/nucleic acid deglycase DJ-1 {ECO:0000305\|PubMed:25416785, ECO:0000305\|PubMed:28596309} - 3.1.2.- {ECO:0000269\|PubMed:25416785} - 3.5.1.- {ECO:0000269\|PubMed:28596309} - 3.5.1.124 {ECO:0000269\|PubMed:25416785} - Maillard deglycase {ECO:0000303\|PubMed:28596309} - Oncogene DJ1 {ECO:0000305} - Parkinson disease protein 7 {ECO:0000305} - Parkinsonism-associated deglycase {ECO:0000312\|HGNC:HGNC:16369} - Protein DJ-1 {ECO:0000305} - DJ-1
Gene names	PARK7
Organism	Homo sapiens
Protease Family	C56.002
Protease ID	C56.002
Chromosome location
UniProt ID	Q99497

19 N-termini

16 C-termini

21 Cleavages

1 Substrates

Sequence

        10         20         30         40         50         60
MASKRALVIL AKGAEEMETV IPVDVMRRAG IKVTVAGLAG KDPVQCSRDV VICPDASLED
        70         80         90        100        110        120
AKKEGPYDVV VLPGGNLGAQ NLSESAAVKE ILKEQENRKG LIAAICAGPT ALLAHEIGFG
       130        140        150        160        170        180
SKVTTHPLAK DKMMNGGHYT YSENRVEKDG LILTSRGPGT SFEFALAIVE ALNGKEVAAQ

VKAPLVLKD

Isoforms

Sequence View

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Evidence Names:

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Lab:

Protein Neighborhood

Domains & Features

19 N-termini - 16 C-termini - 21 Cleavages - 1 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name
Q99497-1-unknown	MASKRA...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q99497-2-acetylation	ASKRAL...	2	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
Q99497-2-acetylation	ASKRAL...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q99497-11-unknown	AKGAEE...	11		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18081
Q99497-12-unknown	KGAEEM...	12		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13133
Q99497-13-unknown	GAEEME...	13		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13134
Q99497-37-unknown	GLAGKD...	37		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6707
Q99497-38-unknown	LAGKDP...	38		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13135
Q99497-38-unknown	LAGKDP...	38		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC4212
Q99497-38-unknown	LAGKDP...	38		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC21625
Q99497-38-unknown	LAGKDP...	38		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC23507
Q99497-40-unknown	GKDPVQ...	40		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000466756
Q99497-48-unknown	RDVVIC...	48		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13136
Q99497-53-unknown	CPDASL...	53		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6708
Q99497-53-unknown	CPDASL...	53		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC8041
Q99497-79-unknown	AQNLSE...	79		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6709
Q99497-82-unknown	LSESAA...	82		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19745
Q99497-82-unknown	LSESAA...	82		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18082
Q99497-84-unknown	ESAAVK...	84		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19746
Q99497-84-unknown	ESAAVK...	84		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18083
Q99497-112-unknown	LLAHEI...	112		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC21626
Q99497-114-unknown	AHEIGF...	114		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC8042
Q99497-146-	VEKDGL...	146			N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
Q99497-150-unknown	GLILTS...	150		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2754
Q99497-175-unknown	KEVAAQ...	175		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC26786
Q99497-183-unknown	APLVLK...	183		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6710
Q99497-183-unknown	APLVLK...	183		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q99497-183-unknown	APLVLK...	183		inferred from similarity	unknown	UniProtKB		inferred from uniprot (by similarity)

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...	0	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...ALVILA	10	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18081
...LVILAK	11	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13133
...VILAKG	12	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13134
...KVTVAG	36	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6707
...VTVAGL	37	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13135
...VTVAGL	37	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4212
...VTVAGL	37	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21625
...VTVAGL	37	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC23507
...PVQCSR	47	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13136
...RDVVIC	52	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6708
...RDVVIC	52	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8041
...GGNLGA	78	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6709
...LGAQNL	81	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19745
...LGAQNL	81	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18082
...AQNLSE	83	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19746
...AQNLSE	83	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18083
...AGPTAL	111	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21626
...PTALLA	113	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8042
...RVEKDG	149	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2754
...EALNGK	174	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26786
...AAQVKA	182	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6710

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MEP1A_HUMAN	10	VILA.\|.AKGA	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
GRAB_HUMAN	11	ILAK.\|.KGAE	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
GRAB_HUMAN	12	LAKG.\|.GAEE	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
CATL1_HUMAN	36	TVAG.\|.GLAG	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
GRAB_HUMAN	37	VAGL.\|.LAGK	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
CATB_HUMAN	37	VAGL.\|.LAGK	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
MMP14_HUMAN	37	VAGL.\|.LAGK	inferred from experiment	unknown	MEROPS	Overall CM	Butler GS et al.:Pharmacoproteomics of a metallo... (M10.014)	18505826,
MMP2_HUMAN	37	VAGL.\|.LAGK	inferred from experiment	unknown	MEROPS	Overall CM	Schilling O et al.:Proteome-derived, database-sear... (C14.003)	18500335,
GRAB_HUMAN	47	QCSR.\|.RDVV	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
CATL1_HUMAN	52	VVIC.\|.CPDA	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATS_HUMAN	52	VVIC.\|.CPDA	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	78	NLGA.\|.AQNL	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
MEP1B_HUMAN	81	AQNL.\|.LSES	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	81	AQNL.\|.LSES	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	83	NLSE.\|.ESAA	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	83	NLSE.\|.ESAA	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MMP14_HUMAN	111	PTAL.\|.LLAH	inferred from experiment	unknown	MEROPS	Overall CM	Butler GS et al.:Pharmacoproteomics of a metallo... (M10.014)	18505826,
CATS_HUMAN	113	ALLA.\|.AHEI	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CASP6_HUMAN	149	EKDG.\|.GLIL	inferred from experiment	unknown	MEROPS	Alves da Costa C	Giaime E et al.:Loss of function of DJ-1 trigge... (C14.005)	19680261,
PARK7_HUMAN	174	LNGK.\|.KEVA	inferred from experiment	unknown	MEROPS	Chin LS	Chen J et al.:Parkinson disease protein DJ-1 ... (C56.002)	20304780,
CATL1_HUMAN	182	QVKA.\|.APLV	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
PARK7_HUMAN	174	LNGK.\|.KEVA	inferred from experiment	unknown	MEROPS	Chin LS	Chen J et al.:Parkinson disease protein DJ-1 ... (C56.002)	20304780,