Q99988: Growth/differentiation factor 15 {ECO:0000305}
| Protein names | - Growth/differentiation factor 15 {ECO:0000305} - GDF-15 {ECO:0000305} - Macrophage inhibitory cytokine 1 {ECO:0000305} - MIC-1 {ECO:0000303|PubMed:28846099} - NSAID-activated gene 1 protein - NAG-1 - NSAID-regulated gene 1 protein - NRG-1 - Placental TGF-beta - Placental bone morphogenetic protein - Prostate differentiation factor |
|---|---|
| Gene names | GDF15 |
| Organism | Homo sapiens |
| Protease Family | |
| Protease ID | |
| Chromosome location | |
| UniProt ID | Q99988 |
3
N-termini
3
C-termini
1
Cleavages
0
Substrates
Sequence
10 20 30 40 50 60
MPGQELRTVN GSQMLLVLLV LSWLPHGGAL SLAEASRASF PGPSELHSED SRFRELRKRY
70 80 90 100 110 120
EDLLTRLRAN QSWEDSNTDL VPAPAVRILT PEVRLGSGGH LHLRISRAAL PEGLPEASRL
130 140 150 160 170 180
HRALFRLSPT ASRSWDVTRP LRRQLSLARP QAPALHLRLS PPPSQSDQLL AESSSARPQL
190 200 210 220 230 240
ELHLRPQAAR GRRRARARNG DHCPLGPGRC CRLHTVRASL EDLGWADWVL SPREVQVTMC
250 260 270 280 290 300
IGACPSQFRA ANMHAQIKTS LHRLKPDTVP APCCVPASYN PMVLIQKTDT GVSLQTYDDL
LAKDCHCI
Isoforms
Sequence View
Protein Neighborhood
Domains & Features
3 N-termini - 3 C-termini - 1 Cleavages - 0 Substrates
N-termini
| Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
|---|---|---|---|---|---|---|---|---|---|
| Q99988-30-unknown | LSLAEA... | 30 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
| Q99988-195-unknown | ARARNG... | 195 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
| Q99988-253-unknown | MHAQIK... | 253 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC21627 |
C-termini
| Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|---|---|---|---|---|---|---|---|
| ...ALPEGL | 113 | inferred from electronic annotation | unknown | Ensembl | inferred from ensembl protein ENSP00000470531 | |||
| ...FRAANM | 252 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC21627 | |||
| ...DCHCI | 308 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot |
Cleavages
| Protease | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|---|---|---|---|---|---|---|---|
| MMP14_HUMAN | 252 | AANM.|.MHAQ | inferred from experiment | unknown | MEROPS | Sato H | Abd El-Aziz SH et al.:Cleavage of growth differentiat... (M10.014) | 17640303, |
Substrates
| Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|