Q13753: Laminin subunit gamma-2

General Information

Protein names	- Laminin subunit gamma-2 - Cell-scattering factor 140 kDa subunit - CSF 140 kDa subunit - Epiligrin subunit gamma - Kalinin subunit gamma - Kalinin/nicein/epiligrin 100 kDa subunit - Ladsin 140 kDa subunit - Laminin B2t chain - Laminin-5 subunit gamma - Large adhesive scatter factor 140 kDa subunit - Nicein subunit gamma
Gene names	LAMC2
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q13753

11 N-termini

10 C-termini

12 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MPALWLGCCL CFSLLLPAAR ATSRREVCDC NGKSRQCIFD RELHRQTGNG FRCLNCNDNT
        70         80         90        100        110        120
DGIHCEKCKN GFYRHRERDR CLPCNCNSKG SLSARCDNSG RCSCKPGVTG ARCDRCLPGF
       130        140        150        160        170        180
HMLTDAGCTQ DQRLLDSKCD CDPAGIAGPC DAGRCVCKPA VTGERCDRCR SGYYNLDGGN
       190        200        210        220        230        240
PEGCTQCFCY GHSASCRSSA EYSVHKITST FHQDVDGWKA VQRNGSPAKL QWSQRHQDVF
       250        260        270        280        290        300
SSAQRLDPVY FVAPAKFLGN QQVSYGQSLS FDYRVDRGGR HPSAHDVILE GAGLRITAPL
       310        320        330        340        350        360
MPLGKTLPCG LTKTYTFRLN EHPSNNWSPQ LSYFEYRRLL RNLTALRIRA TYGEYSTGYI
       370        380        390        400        410        420
DNVTLISARP VSGAPAPWVE QCICPVGYKG QFCQDCASGY KRDSARLGPF GTCIPCNCQG
       430        440        450        460        470        480
GGACDPDTGD CYSGDENPDI ECADCPIGFY NDPHDPRSCK PCPCHNGFSC SVMPETEEVV
       490        500        510        520        530        540
CNNCPPGVTG ARCELCADGY FGDPFGEHGP VRPCQPCQCN NNVDPSASGN CDRLTGRCLK
       550        560        570        580        590        600
CIHNTAGIYC DQCKAGYFGD PLAPNPADKC RACNCNPMGS EPVGCRSDGT CVCKPGFGGP
       610        620        630        640        650        660
NCEHGAFSCP ACYNQVKIQM DQFMQQLQRM EALISKAQGG DGVVPDTELE GRMQQAEQAL
       670        680        690        700        710        720
QDILRDAQIS EGASRSLGLQ LAKVRSQENS YQSRLDDLKM TVERVRALGS QYQNRVRDTH
       730        740        750        760        770        780
RLITQMQLSL AESEASLGNT NIPASDHYVG PNGFKSLAQE ATRLAESHVE SASNMEQLTR
       790        800        810        820        830        840
ETEDYSKQAL SLVRKALHEG VGSGSGSPDG AVVQGLVEKL EKTKSLAQQL TREATQAEIE
       850        860        870        880        890        900
ADRSYQHSLR LLDSVSRLQG VSDQSFQVEE AKRIKQKADS LSSLVTRHMD EFKRTQKNLG
       910        920        930        940        950        960
NWKEEAQQLL QNGKSGREKS DQLLSRANLA KSRAQEALSM GNATFYEVES ILKNLREFDL
       970        980        990       1000       1010       1020
QVDNRKAEAE EAMKRLSYIS QKVSDASDKT QQAERALGSA AADAQRAKNG AGEALEISSE
      1030       1040       1050       1060       1070       1080
IEQEIGSLNL EANVTADGAL AMEKGLASLK SEMREVEGEL ERKELEFDTN MDAVQMVITE
      1090       1100       1110       1120       1130       1140
AQKVDTRAKN AGVTIQDTLN TLDGLLHLMD QPLSVDEEGL VLLEQKLSRA KTQINSQLRP
      1150       1160       1170       1180       1190
MMSELEERAR QQRGHLHLLE TSIDGILADV KNLENIRDNL PPGCYNTQAL EQQ

Isoforms

- Isoform Short of Laminin subunit gamma-2

Sequence View

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Evidence Names:

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Protein Neighborhood

Domains & Features

11 N-termini - 10 C-termini - 12 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
Q13753-1-unknown	MPALWL...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt79341
Q13753-22-unknown	TSRREV...	22	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q13753-22-unknown	TSRREV...	22	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt112905
Q13753-136-unknown	DSKCDC...	136	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19466
Q13753-136-unknown	DSKCDC...	136	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17913
Q13753-136-unknown	DSKCDC...	136	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt144100
Q13753-435-unknown	DENPDI...	435	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31842
Q13753-435-unknown	DENPDI...	435	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt152553
Q13753-437-unknown	NPDIEC...	437	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19468
Q13753-437-unknown	NPDIEC...	437	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt152579
Q13753-560-unknown	DPLAPN...	560	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21618
Q13753-560-unknown	DPLAPN...	560	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt154111
Q13753-580-unknown	SEPVGC...	580	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21620
Q13753-580-unknown	SEPVGC...	580	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt154326
Q13753-599-unknown	GPNCEH...	599	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9503
Q13753-599-unknown	GPNCEH...	599	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt154570
Q13753-607-unknown	FSCPAC...	607	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9505
Q13753-607-unknown	FSCPAC...	607	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt154688
Q13753-863-unknown	DQSFQV...	863	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19470
Q13753-863-unknown	DQSFQV...	863	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17915
Q13753-863-unknown	DQSFQV...	863	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt156720
Q13753-1072-unknown	DAVQMV...	1072	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19472
Q13753-1072-unknown	DAVQMV...	1072	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17917
Q13753-1072-unknown	DAVQMV...	1072	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt157304

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...DQRLLD	135	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19466
...DQRLLD	135	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17913
...DQRLLD	135	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt127351
...DCYSGD	434	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31842
...DCYSGD	434	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt135967
...YSGDEN	436	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19468
...YSGDEN	436	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt135995
...AGYFGD	559	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21618
...AGYFGD	559	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt137531
...CNPMGS	579	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21620
...CNPMGS	579	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt137747
...KPGFGG	598	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9503
...KPGFGG	598	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt137994
...CEHGAF	606	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9505
...CEHGAF	606	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt138113
...LQGVSD	862	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19470
...LQGVSD	862	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17915
...LQGVSD	862	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt140208
...FDTNMD	1071	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19472
...FDTNMD	1071	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17917
...FDTNMD	1071	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt140803
...ALEQQ	1193	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MEP1B_HUMAN	135	RLLD.\|.DSKC	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	135	RLLD.\|.DSKC	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
TLL1_HUMAN	434	YSGD.\|.DENP	inferred from experiment	unknown	MEROPS	Greenspan DS	Ge G et al.:Bone morphogenetic protein-1/to... (M12.016)	15292192,
MEP1B_HUMAN	436	GDEN.\|.NPDI	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MMP14_HUMAN	559	YFGD.\|.DPLA	inferred from experiment	unknown	MEROPS	Seiki M	Koshikawa N et al.:Membrane-type matrix metallopro... (M10.014)	15525652,
MMP14_HUMAN	579	PMGS.\|.SEPV	inferred from experiment	unknown	MEROPS	Seiki M	Koshikawa N et al.:Membrane-type matrix metallopro... (M10.014)	15525652,
ELNE_HUMAN	598	GFGG.\|.GPNC	inferred from experiment	unknown	MEROPS	Senior RM	Mydel P et al.:Neutrophil elastase cleaves lam... (S01.131)	18178964,
ELNE_HUMAN	606	HGAF.\|.FSCP	inferred from experiment	unknown	MEROPS	Senior RM	Mydel P et al.:Neutrophil elastase cleaves lam... (S01.131)	18178964,
MEP1B_HUMAN	862	GVSD.\|.DQSF	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	862	GVSD.\|.DQSF	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	1071	TNMD.\|.DAVQ	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	1071	TNMD.\|.DAVQ	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)