P17931: Galectin-3

General Information

Protein names	- Galectin-3 - Gal-3 - 35 kDa lectin - Carbohydrate-binding protein 35 - CBP 35 - Galactose-specific lectin 3 - Galactoside-binding protein - GALBP - IgE-binding protein - L-31 - Laminin-binding protein - Lectin L-29 - Mac-2 antigen
Gene names	LGALS3
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P17931

5 N-termini

5 C-termini

6 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MADNFSLHDA LSGSGNPNPQ GWPGAWGNQP AGAGGYPGAS YPGAYPGQAP PGAYPGQAPP
        70         80         90        100        110        120
GAYPGAPGAY PGAPAPGVYP GPPSGPGAYP SSGQPSATGA YPATGPYGAP AGPLIVPYNL
       130        140        150        160        170        180
PLPGGVVPRM LITILGTVKP NANRIALDFQ RGNDVAFHFN PRFNENNRRV IVCNTKLDNN
       190        200        210        220        230        240
WGREERQSVF PFESGKPFKI QVLVEPDHFK VAVNDAHLLQ YNHRVKKLNE ISKLGISGDI
       250
DLTSASYTMI

Isoforms

Sequence View

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Methodology:

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Protease Assignment Confidence:

Evidence Names:

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Protein Neighborhood

Domains & Features

5 N-termini - 5 C-termini - 6 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Evidence name
P17931-2-unknown	MADNFS...	1		inferred from similarity	unknown	UniProtKB	inferred from uniprot (by similarity)
P17931-2-unknown	MADNFS...	1		inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P17931-2-Acetylation	ADNFSL...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P17931-2-Acetylation	ADNFSL...	2	acetylation-	inferred from similarity	unknown	UniProtKB	inferred from uniprot (by similarity)
P17931-63-unknown	YPGAPG...	63		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC22791
P17931-63-unknown	YPGAPG...	63		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26393
P17931-63-unknown	YPGAPG...	63		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21584
P17931-63-unknown	YPGAPG...	63		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC24719
P17931-77-unknown	GVYPGP...	77		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC24720
P17931-114-unknown	LIVPYN...	114		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC24721

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...APPGAY	62	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC22791
...APPGAY	62	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26393
...APPGAY	62	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21584
...APPGAY	62	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC24719
...GAPAPG	76	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC24720
...SGPGAY	88	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000451526
...APAGPL	113	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC24721
...SYTMI	250	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MMP2_HUMAN	62	PGAY.\|.YPGA	inferred from experiment	unknown	MEROPS	Raz A	Ochieng J et al.:Galectin-3 is a novel substrate... (M10.003)	7947821,
MMP9_HUMAN	62	PGAY.\|.YPGA	inferred from experiment	unknown	MEROPS	Raz A	Ochieng J et al.:Galectin-3 is a novel substrate... (M10.003)	7947821,
MMP14_HUMAN	62	PGAY.\|.YPGA	inferred from experiment	unknown	MEROPS	Raz A	Nangia-Makker P et al.:Galectin-3 cleavage: a novel su... (M10.014)	18089806,
MMP7_HUMAN	62	PGAY.\|.YPGA	inferred from experiment	unknown	MEROPS	Kwon JH	Puthenedam M et al.:Matrilysin-1 (MMP7) cleaves gal... (M10.008)	20812334,
MMP7_HUMAN	76	PAPG.\|.GVYP	inferred from experiment	unknown	MEROPS	Kwon JH	Puthenedam M et al.:Matrilysin-1 (MMP7) cleaves gal... (M10.008)	20812334,
MMP7_HUMAN	113	AGPL.\|.LIVP	inferred from experiment	unknown	MEROPS	Kwon JH	Puthenedam M et al.:Matrilysin-1 (MMP7) cleaves gal... (M10.008)	20812334,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)