P28799: Progranulin {ECO:0000303|PubMed:16862116}

General Information

Protein names	- Progranulin {ECO:0000303\|PubMed:16862116} - PGRN {ECO:0000303\|PubMed:16862116} - Acrogranin {ECO:0000250\|UniProtKB:P28798} - Epithelin precursor {ECO:0000303\|PubMed:1618805} - Glycoprotein of 88 Kda {ECO:0000250\|UniProtKB:P28798} - GP88 - Glycoprotein 88 - Granulin precursor {ECO:0000303\|PubMed:1542665} - PC cell-derived growth factor {ECO:0000250\|UniProtKB:P28798} - PCDGF {ECO:0000303\|Ref.4} - Proepithelin {ECO:0000303\|PubMed:12526812, ECO:0000303\|PubMed:1618805} - PEPI {ECO:0000303\|PubMed:12526812} - Paragranulin - Granulin-1 - Granulin G - Granulin-2 - Granulin F - Granulin-3 - Epithelin-2 {ECO:0000250\|UniProtKB:P23785} - Granulin B - Granulin-4 - Epithelin-1 {ECO:0000250\|UniProtKB:P23785} - Granulin A - Granulin-5 - Granulin C - Granulin-6 - Granulin D - Granulin-7 - Granulin E
Gene names	GRN
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P28799

6 N-termini

3 C-termini

3 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Granulins - Isoform 3 of Granulins - Isoform 2 of Progranulin - Isoform 3 of Progranulin

Sequence View

        10         20         30         40         50         60
MWTLVSWVAL TAGLVAGTRC PDGQFCPVAC CLDPGGASYS CCRPLLDKWP TTLSRHLGGP
        70         80         90        100        110        120
CQVDAHCSAG HSCIFTVSGT SSCCPFPEAV ACGDGHHCCP RGFHCSADGR SCFQRSGNNS
       130        140        150        160        170        180
VGAIQCPDSQ FECPDFSTCC VMVDGSWGCC PMPQASCCED RVHCCPHGAF CDLVHTRCIT
       190        200        210        220        230        240
PTGTHPLAKK LPAQRTNRAV ALSSSVMCPD ARSRCPDGST CCELPSGKYG CCPMPNATCC
       250        260        270        280        290        300
SDHLHCCPQD TVCDLIQSKC LSKENATTDL LTKLPAHTVG DVKCDMEVSC PDGYTCCRLQ
       310        320        330        340        350        360
SGAWGCCPFT QAVCCEDHIH CCPAGFTCDT QKGTCEQGPH QVPWMEKAPA HLSLPDPQAL
       370        380        390        400        410        420
KRDVPCDNVS SCPSSDTCCQ LTSGEWGCCP IPEAVCCSDH QHCCPQGYTC VAEGQCQRGS
       430        440        450        460        470        480
EIVAGLEKMP ARRASLSHPR DIGCDQHTSC PVGQTCCPSL GGSWACCQLP HAVCCEDRQH
       490        500        510        520        530        540
CCPAGYTCNV KARSCEKEVV SAQPATFLAR SPHVGVKDVE CGEGHFCHDN QTCCRDNRQG
       550        560        570        580        590
WACCPYRQGV CCADRRHCCP AGFRCAARGT KCLRREAPRW DAPLRDPALR QLL         10         20         30         40         50         60
MWTLVSWVAL TAGLVAGTRC PDGQFCPVAC CLDPGGASYS CCRPLLDKWP TTLSRHLGGP
        70         80         90        100        110        120
CQVDAHCSAG HSCIFTVSGT SSCCPFPEAV ACGDGHHCCP RGFHCSADGR SCFQRSGNNS
       130        140        150        160        170        180
VGAIQCPDSQ FECPDFSTCC VMVDGSWGCC PMPQASCCED RVHCCPHGAF CDLVHTRCIT
       190        200        210        220        230        240
PTGTHPLAKK LPAQRTNRAV ALSSSVMCPD ARSRCPDGST CCELPSGKYG CCPMPNATCC
       250        260        270        280        290        300
SDHLHCCPQD TVCDLIQSKC LSKENATTDL LTKLPAHTVG DVKCDMEVSC PDGYTCCRLQ
       310        320        330        340        350        360
SGAWGCCPFT QAVCCEDHIH CCPAGFTCDT QKGTCEQGPH QVPWMEKAPA HLSLPDPQAL
       370        380        390        400        410        420
KRDVPCDNVS SCPSSDTCCQ LTSGEWGCCP IPEAVCCSDH QHCCPQGYTC VAEGQCQRGS
       430        440        450        460        470        480
EIVAGLEKMP ARRASLSHPR DIGCDQHTSC PVGQTCCPSL GGSWACCQLP HAVCCEDRQH
       490        500        510        520        530        540
CCPAGYTCNV KARSCEKEVV SAQPATFLAR SPHVGVKDVE CGEGHFCHDN QTCCRDNRQG
       550        560        570        580        590
WACCPYRQGV CCADRRHCCP AGFRCAARGT KCLRREAPRW DAPLRDPALR QLL         10         20         30         40         50         60
MWTLVSWVAL TAGLVAGTRC PDGQFCPVAC CLDPGGASYS CCRPLLDKWP TTLSRHLGGP
        70         80         90        100        110        120
CQVDAHCSAG HSCIFTVSGT SSCCPFPEAV ACGDGHHCCP RGFHCSADGR SCFQRSGNNS
       130        140        150        160        170        180
VGAIQCPDSQ FECPDFSTCC VMVDGSWGCC PMPQASCCED RVHCCPHGAF CDLVHTRCIT
       190        200        210        220        230        240
PTGTHPLAKK LPAQRTNRAV ALSSSVMCPD ARSRCPDGST CCELPSGKYG CCPMPNATCC
       250        260        270        280        290        300
SDHLHCCPQD TVCDLIQSKC LSKENATTDL LTKLPAHTVG DVKCDMEVSC PDGYTCCRLQ
       310        320        330        340        350        360
SGAWGCCPFT QAVCCEDHIH CCPAGFTCDT QKGTCEQGPH QVPWMEKAPA HLSLPDPQAL
       370        380        390        400        410        420
KRDVPCDNVS SCPSSDTCCQ LTSGEWGCCP IPEAVCCSDH QHCCPQGYTC VAEGQCQRGS
       430        440        450        460        470        480
EIVAGLEKMP ARRASLSHPR DIGCDQHTSC PVGQTCCPSL GGSWACCQLP HAVCCEDRQH
       490        500        510        520        530        540
CCPAGYTCNV KARSCEKEVV SAQPATFLAR SPHVGVKDVE CGEGHFCHDN QTCCRDNRQG
       550        560        570        580        590
WACCPYRQGV CCADRRHCCP AGFRCAARGT KCLRREAPRW DAPLRDPALR QLL         10         20         30         40         50         60
MWTLVSWVAL TAGLVAGTRC PDGQFCPVAC CLDPGGASYS CCRPLLDKWP TTLSRHLGGP
        70         80         90        100        110        120
CQVDAHCSAG HSCIFTVSGT SSCCPFPEAV ACGDGHHCCP RGFHCSADGR SCFQRSGNNS
       130        140        150        160        170        180
VGAIQCPDSQ FECPDFSTCC VMVDGSWGCC PMPQASCCED RVHCCPHGAF CDLVHTRCIT
       190        200        210        220        230        240
PTGTHPLAKK LPAQRTNRAV ALSSSVMCPD ARSRCPDGST CCELPSGKYG CCPMPNATCC
       250        260        270        280        290        300
SDHLHCCPQD TVCDLIQSKC LSKENATTDL LTKLPAHTVG DVKCDMEVSC PDGYTCCRLQ
       310        320        330        340        350        360
SGAWGCCPFT QAVCCEDHIH CCPAGFTCDT QKGTCEQGPH QVPWMEKAPA HLSLPDPQAL
       370        380        390        400        410        420
KRDVPCDNVS SCPSSDTCCQ LTSGEWGCCP IPEAVCCSDH QHCCPQGYTC VAEGQCQRGS
       430        440        450        460        470        480
EIVAGLEKMP ARRASLSHPR DIGCDQHTSC PVGQTCCPSL GGSWACCQLP HAVCCEDRQH
       490        500        510        520        530        540
CCPAGYTCNV KARSCEKEVV SAQPATFLAR SPHVGVKDVE CGEGHFCHDN QTCCRDNRQG
       550        560        570        580        590
WACCPYRQGV CCADRRHCCP AGFRCAARGT KCLRREAPRW DAPLRDPALR QLL

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

6 N-termini - 3 C-termini - 3 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P28799-1-unknown	MWTLVS...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt76499
P28799-18-unknown	TRCPDG...	18	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P28799-18-unknown	TRCPDG...	18	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt111957
P28799-205-	SVMCPD...	205		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P28799-205-	SVMCPD...	205		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P28799-205-unknown	SVMCPD...	205		unknown			Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P28799-205-unknown	SVMCPD...	205	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt171844
P28799-351-unknown	HLSLPD...	351	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18995
P28799-351-unknown	HLSLPD...	351	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17540
P28799-351-unknown	HLSLPD...	351	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt145554
P28799-351-unknown	HLSLPD...	351	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt150954
P28799-360-unknown	LKRDVP...	360	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC21593
P28799-360-unknown	LKRDVP...	360	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt145893

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...EKAPAH	350	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18995
...EKAPAH	350	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17540
...EKAPAH	350	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt128852
...EKAPAH	350	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt134356
...PDPQAL	359	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21593
...PDPQAL	359	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt129189
...PDPQAL	359	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt134567
...LRQLL	593	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...LRQLL	593	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt72118
...LRQLL	593	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt72117

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MEP1B_HUMAN	350	APAH.\|.HLSL	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	350	APAH.\|.HLSL	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MMP14_HUMAN	359	PQAL.\|.LKRD	inferred from experiment	unknown	MEROPS	Overall CM	Butler GS et al.:Pharmacoproteomics of a metallo... (M10.014)	18505826,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)