O43915: Vascular endothelial growth factor D {ECO:0000312|HGNC:HGNC:3708}

General Information

Protein names	- Vascular endothelial growth factor D {ECO:0000312\|HGNC:HGNC:3708} - VEGF-D - c-Fos-induced growth factor - FIGF
Gene names	FIGF
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	O43915

5 N-termini

4 C-termini

9 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MYREWVVVNV FMMLYVQLVQ GSSNEHGPVK RSSQSTLERS EQQIRAASSL EELLRITHSE
        70         80         90        100        110        120
DWKLWRCRLR LKSFTSMDSR SASHRSTRFA ATFYDIETLK VIDEEWQRTQ CSPRETCVEV
       130        140        150        160        170        180
ASELGKSTNT FFKPPCVNVF RCGGCCNEES LICMNTSTSY ISKQLFEISV PLTSVPELVP
       190        200        210        220        230        240
VKVANHTGCK CLPTAPRHPY SIIRRSIQIP EEDRCSHSKK LCPIDMLWDS NKCKCVLQEE
       250        260        270        280        290        300
NPLAGTEDHS HLQEPALCGP HMMFDEDRCE CVCKTPCPKD LIQHPKNCSC FECKESLETC
       310        320        330        340        350
CQKHKLFHPD TCSCEDRCPF HTRPCASGKT ACAKHCRFPK EKRAAQGPHS RKNP

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

5 N-termini - 4 C-termini - 9 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name	Publications (PMID)
O43915-22-unknown	SSNEHG...	22	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
O43915-89-unknown	FAATFY...	89	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
O43915-89-unknown	FAATFY...	89	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27428
O43915-89-unknown	FAATFY...	89	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26946
O43915-89-unknown	FAATFY...	89	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9663
O43915-100-unknown	KVIDEE...	100	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9664
O43915-101-unknown	VIDEEW...	101	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27429
O43915-206-unknown	SIQIPE...	206	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27430
O43915-206-unknown	SIQIPE...	206	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26947
O43915-206-unknown	SIQIPE...	206	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27245
O43915-206-unknown	SIQIPE...	206	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9665
O43915-206-unknown	SIQIPE...	206		unknown		Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...HRSTRF	88	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27428
...HRSTRF	88	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26946
...HRSTRF	88	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9663
...DIETLK	99	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9664
...IETLKV	100	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27429
...SIIRRS	205	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...SIIRRS	205	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27430
...SIIRRS	205	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26947
...SIIRRS	205	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27245
...SIIRRS	205	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9665

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
PLMN_HUMAN	88	STRF.\|.FAAT	inferred from experiment	unknown	MEROPS	Achen MG	McColl BK et al.:Plasmin activates the lymphangi... (S01.233)	12963694,
PCSK5_HUMAN	88	STRF.\|.FAAT	inferred from experiment	unknown	MEROPS	Achen MG	McColl BK et al.:Proprotein convertases promote ... (S08.071)	17242158,
FURIN_HUMAN	88	STRF.\|.FAAT	inferred from experiment	unknown	MEROPS	Achen MG	McColl BK et al.:Proprotein convertases promote ... (S08.071)	17242158,
FURIN_HUMAN	99	ETLK.\|.KVID	inferred from experiment	unknown	MEROPS	Achen MG	McColl BK et al.:Proprotein convertases promote ... (S08.071)	17242158,
PLMN_HUMAN	100	TLKV.\|.VIDE	inferred from experiment	unknown	MEROPS	Achen MG	McColl BK et al.:Plasmin activates the lymphangi... (S01.233)	12963694,
PLMN_HUMAN	205	IRRS.\|.SIQI	inferred from experiment	unknown	MEROPS	Achen MG	McColl BK et al.:Plasmin activates the lymphangi... (S01.233)	12963694,
PCSK5_HUMAN	205	IRRS.\|.SIQI	inferred from experiment	unknown	MEROPS	Achen MG	McColl BK et al.:Proprotein convertases promote ... (S08.071)	17242158,
PCSK7_HUMAN	205	IRRS.\|.SIQI	inferred from experiment	unknown	MEROPS	Achen MG	McColl BK et al.:Proprotein convertases promote ... (S08.071)	17242158,
FURIN_HUMAN	205	IRRS.\|.SIQI	inferred from experiment	unknown	MEROPS	Achen MG	McColl BK et al.:Proprotein convertases promote ... (S08.071)	17242158,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)