Q9UHL4: Dipeptidyl peptidase 2

General Information

Protein names	- Dipeptidyl peptidase 2 - 3.4.14.2 - Dipeptidyl aminopeptidase II - Dipeptidyl peptidase 7 - Dipeptidyl peptidase II - DPP II - Quiescent cell proline dipeptidase
Gene names	DPP7
Organism	Homo sapiens
Protease Family	S28.002
Protease ID	S28.002
Chromosome location
UniProt ID	Q9UHL4

3 N-termini

2 C-termini

0 Cleavages

7 Substrates

Sequence

        10         20         30         40         50         60
MGSAPWAPVL LLALGLRGLQ AGARRAPDPG FQERFFQQRL DHFNFERFGN KTFPQRFLVS
        70         80         90        100        110        120
DRFWVRGEGP IFFYTGNEGD VWAFANNSAF VAELAAERGA LLVFAEHRYY GKSLPFGAQS
       130        140        150        160        170        180
TQRGHTELLT VEQALADFAE LLRALRRDLG AQDAPAIAFG GSYGGMLSAY LRMKYPHLVA
       190        200        210        220        230        240
GALAASAPVL AVAGLGDSNQ FFRDVTADFE GQSPKCTQGV REAFRQIKDL FLQGAYDTVR
       250        260        270        280        290        300
WEFGTCQPLS DEKDLTQLFM FARNAFTVLA MMDYPYPTDF LGPLPANPVK VGCDRLLSEA
       310        320        330        340        350        360
QRITGLRALA GLVYNASGSE HCYDIYRLYH SCADPTGCGT GPDARAWDYQ ACTEINLTFA
       370        380        390        400        410        420
SNNVTDMFPD LPFTDELRQR YCLDTWGVWP RPDWLLTSFW GGDLRAASNI IFSNGNLDPW
       430        440        450        460        470        480
AGGGIRRNLS ASVIAVTIQG GAHHLDLRAS HPEDPASVVE ARKLEATIIG EWVKAARREQ
       490
QPALRGGPRL SL

Isoforms

Sequence View

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Evidence Names:

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Protein Neighborhood

Domains & Features

3 N-termini - 2 C-termini - 0 Cleavages - 7 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
Q9UHL4-4-unknown	APWAPV...	4	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000473618
Q9UHL4-22-unknown	GARRAP...	22	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q9UHL4-26-unknown	APDPGF...	26	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

C-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
	...SNQFFR	202	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000473618
	...PRLSL	492	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Evidence name
TKN1-Isoform4_HUMAN	59	RRPK.\|.KPQQ	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TC8464
TKN1-Isoform3_HUMAN	59	RRPK.\|.KPQQ	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TC8464
TKN1_HUMAN	59	RRPK.\|.KPQQ	inferred from experiment	unknown	MEROPS	Merops DPP2_HUMAN -> TKN1_HUMAN @59
TKN1-Isoform2_HUMAN	59	RRPK.\|.KPQQ	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TC8464
KNG1-Isoform3_HUMAN	346	KRPP.\|.PGFS	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TC8461
KNG1_HUMAN	382	KRPP.\|.PGFS	inferred from experiment	unknown	MEROPS	Merops DPP2_HUMAN -> KNG1_HUMAN @382
KNG1-Isoform2_HUMAN	382	KRPP.\|.PGFS	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TC8461