TopFIND 4.0

P42785: Lysosomal Pro-X carboxypeptidase

General Information

Protein names
- Lysosomal Pro-X carboxypeptidase
- 3.4.16.2
- Angiotensinase C
- Lysosomal carboxypeptidase C
- Proline carboxypeptidase
- Prolylcarboxypeptidase
- PRCP
Gene names PRCP
Organism Homo sapiens
Protease Family S28.001
Protease ID S28.001
Chromosome location
UniProt ID P42785

3

N-termini

1

C-termini

0

Cleavages

5

Substrates

Sequence

        10         20         30         40         50         60 
MGRRALLLLL LSFLAPWATI ALRPALRALG SLHLPTNPTS LPAVAKNYSV LYFQQKVDHF 
        70         80         90        100        110        120 
GFNTVKTFNQ RYLVADKYWK KNGGSILFYT GNEGDIIWFC NNTGFMWDVA EELKAMLVFA 
       130        140        150        160        170        180 
EHRYYGESLP FGDNSFKDSR HLNFLTSEQA LADFAELIKH LKRTIPGAEN QPVIAIGGSY 
       190        200        210        220        230        240 
GGMLAAWFRM KYPHMVVGAL AASAPIWQFE DLVPCGVFMK IVTTDFRKSG PHCSESIHRS 
       250        260        270        280        290        300 
WDAINRLSNT GSGLQWLTGA LHLCSPLTSQ DIQHLKDWIS ETWVNLAMVD YPYASNFLQP 
       310        320        330        340        350        360 
LPAWPIKVVC QYLKNPNVSD SLLLQNIFQA LNVYYNYSGQ VKCLNISETA TSSLGTLGWS 
       370        380        390        400        410        420 
YQACTEVVMP FCTNGVDDMF EPHSWNLKEL SDDCFQQWGV RPRPSWITTM YGGKNISSHT 
       430        440        450        460        470        480 
NIVFSNGELD PWSGGGVTKD ITDTLVAVTI SEGAHHLDLR TKNALDPMSV LLARSLEVRH 
       490    
MKNWIRDFYD SAGKQH

Isoforms

- Isoform 2 of Lysosomal Pro-X carboxypeptidase

Sequence View

        10         20         30         40         50         60 
MGRRALLLLL LSFLAPWATI ALRPALRALG SLHLPTNPTS LPAVAKNYSV LYFQQKVDHF 
        70         80         90        100        110        120 
GFNTVKTFNQ RYLVADKYWK KNGGSILFYT GNEGDIIWFC NNTGFMWDVA EELKAMLVFA 
       130        140        150        160        170        180 
EHRYYGESLP FGDNSFKDSR HLNFLTSEQA LADFAELIKH LKRTIPGAEN QPVIAIGGSY 
       190        200        210        220        230        240 
GGMLAAWFRM KYPHMVVGAL AASAPIWQFE DLVPCGVFMK IVTTDFRKSG PHCSESIHRS 
       250        260        270        280        290        300 
WDAINRLSNT GSGLQWLTGA LHLCSPLTSQ DIQHLKDWIS ETWVNLAMVD YPYASNFLQP 
       310        320        330        340        350        360 
LPAWPIKVVC QYLKNPNVSD SLLLQNIFQA LNVYYNYSGQ VKCLNISETA TSSLGTLGWS 
       370        380        390        400        410        420 
YQACTEVVMP FCTNGVDDMF EPHSWNLKEL SDDCFQQWGV RPRPSWITTM YGGKNISSHT 
       430        440        450        460        470        480 
NIVFSNGELD PWSGGGVTKD ITDTLVAVTI SEGAHHLDLR TKNALDPMSV LLARSLEVRH 
       490    
MKNWIRDFYD SAGKQH



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Protease Assignment Confidence:


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Protein Neighborhood

Domains & Features

3 N-termini - 1 C-termini - 0 Cleavages - 5 Substrates

N-termini

C-termini

    Name Sequence Position Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)
    ...AGKQH 496 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    ...AGKQH 496 inferred from isoform by sequence similarity unknown TopFIND inferred from TCt80203

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates