O00187: Mannan-binding lectin serine protease 2

General Information

Protein names	- Mannan-binding lectin serine protease 2 - 3.4.21.104 - MBL-associated serine protease 2 - Mannose-binding protein-associated serine protease 2 - MASP-2 - Mannan-binding lectin serine protease 2 A chain - Mannan-binding lectin serine protease 2 B chain
Gene names	MASP2
Organism	Homo sapiens
Protease Family	S01.229
Protease ID	S01.229
Chromosome location
UniProt ID	O00187

4 N-termini

3 C-termini

2 Cleavages

8 Substrates

Sequence

        10         20         30         40         50         60
MRLLTLLGLL CGSVATPLGP KWPEPVFGRL ASPGFPGEYA NDQERRWTLT APPGYRLRLY
        70         80         90        100        110        120
FTHFDLELSH LCEYDFVKLS SGAKVLATLC GQESTDTERA PGKDTFYSLG SSLDITFRSD
       130        140        150        160        170        180
YSNEKPFTGF EAFYAAEDID ECQVAPGEAP TCDHHCHNHL GGFYCSCRAG YVLHRNKRTC
       190        200        210        220        230        240
SALCSGQVFT QRSGELSSPE YPRPYPKLSS CTYSISLEEG FSVILDFVES FDVETHPETL
       250        260        270        280        290        300
CPYDFLKIQT DREEHGPFCG KTLPHRIETK SNTVTITFVT DESGDHTGWK IHYTSTAQPC
       310        320        330        340        350        360
PYPMAPPNGH VSPVQAKYIL KDSFSIFCET GYELLQGHLP LKSFTAVCQK DGSWDRPMPA
       370        380        390        400        410        420
CSIVDCGPPD DLPSGRVEYI TGPGVTTYKA VIQYSCEETF YTMKVNDGKY VCEADGFWTS
       430        440        450        460        470        480
SKGEKSLPVC EPVCGLSART TGGRIYGGQK AKPGDFPWQV LILGGTTAAG ALLYDNWVLT
       490        500        510        520        530        540
AAHAVYEQKH DASALDIRMG TLKRLSPHYT QAWSEAVFIH EGYTHDAGFD NDIALIKLNN
       550        560        570        580        590        600
KVVINSNITP ICLPRKEAES FMRTDDIGTA SGWGLTQRGF LARNLMYVDI PIVDHQKCTA
       610        620        630        640        650        660
AYEKPPYPRG SVTANMLCAG LESGGKDSCR GDSGGALVFL DSETERWFVG GIVSWGSMNC
       670        680
GEAGQYGVYT KVINYIPWIE NIISDF

Isoforms

- Isoform 2 of Mannan-binding lectin serine protease 2

Sequence View

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Protein Neighborhood

Domains & Features

4 N-termini - 3 C-termini - 2 Cleavages - 8 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
O00187-1-unknown	MRLLTL...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt80456
O00187-16-unknown	TPLGPK...	16	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
O00187-16-unknown	TPLGPK...	16	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt111811
O00187-291-unknown	IHYTST...	291	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16810
O00187-445-unknown	IYGGQK...	445	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
O00187-445-unknown	IYGGQK...	445	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16811

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...HTGWKI	290	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16810
...TTGGRI	444	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...TTGGRI	444	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16811
...IISDF	686	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MASP2_HUMAN	290	GWKI.\|.IHYT	inferred from experiment	unknown	MEROPS	Zavodszky P	Ambrus G et al.:Natural substrates and inhibito... (S01.229)	12538697,
MASP2_HUMAN	444	GGRI.\|.IYGG	inferred from experiment	unknown	MEROPS	Zavodszky P	Gal P et al.:A true autoactivating enzyme. S... (S01.229)	16040602,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CO2-Isoform3_HUMAN	111	LGRK.\|.KIQI	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC16814
CO2_HUMAN	243	LGRK.\|.KIQI	inferred from experiment	unknown	MEROPS	Fujita T	Matsushita M et al.:Proteolytic activities of two t... (S01.229)	10946292,
MASP2_HUMAN	290	GWKI.\|.IHYT	inferred from experiment	unknown	MEROPS	Zavodszky P	Ambrus G et al.:Natural substrates and inhibito... (S01.229)	12538697,
THRB_HUMAN	327	NPRT.\|.TFGS	inferred from experiment	unknown	MEROPS	Sim RB	Krarup A et al.:Simultaneous activation of comp... (S01.229)	17637839,
MASP2_HUMAN	444	GGRI.\|.IYGG	inferred from experiment	unknown	MEROPS	Zavodszky P	Gal P et al.:A true autoactivating enzyme. S... (S01.229)	16040602,
IC1_HUMAN	466	VART.\|.TLLV	inferred from experiment	unknown	MEROPS	Pike RN	Duncan RC et al.:The initiating proteases of the... (S01.192)	17850949,
CO4A_HUMAN	756	LQRA.\|.ALEI	inferred from experiment	unknown	MEROPS	Fujita T	Matsushita M et al.:Proteolytic activities of two t... (S01.229)	10946292,
CO4A-Isoform2_HUMAN	756	LQRA.\|.ALEI	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC16816