P05155: Plasma protease C1 inhibitor

General Information

Protein names	- Plasma protease C1 inhibitor - C1 Inh - C1Inh - C1 esterase inhibitor - C1-inhibiting factor - Serpin G1
Gene names	SERPING1
Organism	Homo sapiens
Protease Family
Protease ID	I04.024
Chromosome location
UniProt ID	P05155

12 N-termini

6 C-termini

5 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Plasma protease C1 inhibitor - Isoform 3 of Plasma protease C1 inhibitor

Sequence View

        10         20         30         40         50         60
MASRLTLLTL LLLLLAGDRA SSNPNATSSS SQDPESLQDR GEGKVATTVI SKMLFVEPIL
        70         80         90        100        110        120
EVSSLPTTNS TTNSATKITA NTTDEPTTQP TTEPTTQPTI QPTQPTTQLP TDSPTQPTTG
       130        140        150        160        170        180
SFCPGPVTLC SDLESHSTEA VLGDALVDFS LKLYHAFSAM KKVETNMAFS PFSIASLLTQ
       190        200        210        220        230        240
VLLGAGENTK TNLESILSYP KDFTCVHQAL KGFTTKGVTS VSQIFHSPDL AIRDTFVNAS
       250        260        270        280        290        300
RTLYSSSPRV LSNNSDANLE LINTWVAKNT NNKISRLLDS LPSDTRLVLL NAIYLSAKWK
       310        320        330        340        350        360
TTFDPKKTRM EPFHFKNSVI KVPMMNSKKY PVAHFIDQTL KAKVGQLQLS HNLSLVILVP
       370        380        390        400        410        420
QNLKHRLEDM EQALSPSVFK AIMEKLEMSK FQPTLLTLPR IKVTTSQDML SIMEKLEFFD
       430        440        450        460        470        480
FSYDLNLCGL TEDPDLQVSA MQHQTVLELT ETGVEAAAAS AISVARTLLV FEVQQPFLFV
       490        500
LWDQQHKFPV FMGRVYDPRA         10         20         30         40         50         60
MASRLTLLTL LLLLLAGDRA SSNPNATSSS SQDPESLQDR GEGKVATTVI SKMLFVEPIL
        70         80         90        100        110        120
EVSSLPTTNS TTNSATKITA NTTDEPTTQP TTEPTTQPTI QPTQPTTQLP TDSPTQPTTG
       130        140        150        160        170        180
SFCPGPVTLC SDLESHSTEA VLGDALVDFS LKLYHAFSAM KKVETNMAFS PFSIASLLTQ
       190        200        210        220        230        240
VLLGAGENTK TNLESILSYP KDFTCVHQAL KGFTTKGVTS VSQIFHSPDL AIRDTFVNAS
       250        260        270        280        290        300
RTLYSSSPRV LSNNSDANLE LINTWVAKNT NNKISRLLDS LPSDTRLVLL NAIYLSAKWK
       310        320        330        340        350        360
TTFDPKKTRM EPFHFKNSVI KVPMMNSKKY PVAHFIDQTL KAKVGQLQLS HNLSLVILVP
       370        380        390        400        410        420
QNLKHRLEDM EQALSPSVFK AIMEKLEMSK FQPTLLTLPR IKVTTSQDML SIMEKLEFFD
       430        440        450        460        470        480
FSYDLNLCGL TEDPDLQVSA MQHQTVLELT ETGVEAAAAS AISVARTLLV FEVQQPFLFV
       490        500
LWDQQHKFPV FMGRVYDPRA

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

12 N-termini - 6 C-termini - 5 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name	Publications (PMID)
P05155-23-unknown	NPNATS...	23	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P05155-26-unknown	ATSSSS...	26		unknown		Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P05155-27-unknown	TSSSSQ...	27		unknown		Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P05155-29-unknown	SSSQDP...	29		unknown		Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P05155-30-unknown	SSQDPE...	30		unknown		Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P05155-31-unknown	SQDPES...	31		unknown		Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P05155-53-unknown	MLFVEP...	53	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000367575
P05155-56-unknown	VEPILE...	56	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8412
P05155-242-unknown	TLYSSS...	242		unknown		Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P05155-317-unknown	NSVIKV...	317		unknown		Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P05155-462-unknown	ISVART...	462	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC25068
P05155-467-unknown	TLLVFE...	467	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16813
P05155-467-unknown	TLLVFE...	467	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC707
P05155-467-unknown	TLLVFE...	467	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC709

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...SKMLFV	55	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8412
...DEPTTQ	88	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000399746
...AFSAMK	160	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000384561
...AAASAI	461	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC25068
...ISVART	466	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16813
...ISVART	466	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC707
...ISVART	466	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC709
...YDPRA	500	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CMA1_HUMAN	55	MLFV.\|.VEPI	inferred from experiment	unknown	MEROPS	Caughey GH	Raymond WW et al.:Albumin is a substrate of human... (S01.140)	12815038,
MMP8_HUMAN	461	ASAI.\|.ISVA	inferred from experiment	unknown	MEROPS		Merops MMP8_HUMAN -> IC1_HUMAN @461
MMP8_HUMAN	461	ASAI.\|.ISVA	inferred from experiment	unknown	MEROPS	Tschesche H	Knauper V et al.:Inactivation of human plasma C1... (M10.002)	1655539,
MASP2_HUMAN	466	VART.\|.TLLV	inferred from experiment	unknown	MEROPS	Pike RN	Duncan RC et al.:The initiating proteases of the... (S01.192)	17850949,
C1R_HUMAN	466	VART.\|.TLLV	inferred from experiment	unknown	MEROPS	Pike RN	Duncan RC et al.:The initiating proteases of the... (S01.192)	17850949,
C1S_HUMAN	466	VART.\|.TLLV	inferred from experiment	unknown	MEROPS	Pike RN	Duncan RC et al.:The initiating proteases of the... (S01.192)	17850949,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)