P00736: Complement C1r subcomponent

General Information

Protein names	- Complement C1r subcomponent - 3.4.21.41 - Complement component 1 subcomponent r - Complement C1r subcomponent heavy chain - Complement C1r subcomponent light chain
Gene names	C1R
Organism	Homo sapiens
Protease Family	S01.192
Protease ID	S01.192
Chromosome location
UniProt ID	P00736

8 N-termini

7 C-termini

2 Cleavages

4 Substrates

Sequence

        10         20         30         40         50         60
MWLLYLLVPA LFCRAGGSIP IPQKLFGEVT SPLFPKPYPN NFETTTVITV PTGYRVKLVF
        70         80         90        100        110        120
QQFDLEPSEG CFYDYVKISA DKKSLGRFCG QLGSPLGNPP GKKEFMSQGN KMLLTFHTDF
       130        140        150        160        170        180
SNEENGTIMF YKGFLAYYQA VDLDECASRS KSGEEDPQPQ CQHLCHNYVG GYFCSCRPGY
       190        200        210        220        230        240
ELQEDTHSCQ AECSSELYTE ASGYISSLEY PRSYPPDLRC NYSIRVERGL TLHLKFLEPF
       250        260        270        280        290        300
DIDDHQQVHC PYDQLQIYAN GKNIGEFCGK QRPPDLDTSS NAVDLLFFTD ESGDSRGWKL
       310        320        330        340        350        360
RYTTEIIKCP QPKTLDEFTI IQNLQPQYQF RDYFIATCKQ GYQLIEGNQV LHSFTAVCQD
       370        380        390        400        410        420
DGTWHRAMPR CKIKDCGQPR NLPNGDFRYT TTMGVNTYKA RIQYYCHEPY YKMQTRAGSR
       430        440        450        460        470        480
ESEQGVYTCT AQGIWKNEQK GEKIPRCLPV CGKPVNPVEQ RQRIIGGQKA KMGNFPWQVF
       490        500        510        520        530        540
TNIHGRGGGA LLGDRWILTA AHTLYPKEHE AQSNASLDVF LGHTNVEELM KLGNHPIRRV
       550        560        570        580        590        600
SVHPDYRQDE SYNFEGDIAL LELENSVTLG PNLLPICLPD NDTFYDLGLM GYVSGFGVME
       610        620        630        640        650        660
EKIAHDLRFV RLPVANPQAC ENWLRGKNRM DVFSQNMFCA GHPSLKQDAC QGDSGGVFAV
       670        680        690        700
RDPNTDRWVA TGIVSWGIGC SRGYGFYTKV LNYVDWIKKE MEEED

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

8 N-termini - 7 C-termini - 2 Cleavages - 4 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name	Publications (PMID)
P00736-2-unknown	WLLYLL...	2	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000438615
P00736-16-unknown	GGSIPI...	16		unknown		Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P00736-18-unknown	SIPIPQ...	18	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P00736-18-unknown	SIPIPQ...	18		unknown		Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P00736-90-unknown	GQLGSP...	90		unknown		Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P00736-90-unknown	GQLGSP...	90	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P00736-106-unknown	MSQGNK...	106	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000439223
P00736-106-unknown	MSQGNK...	106	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000441601
P00736-106-unknown	MSQGNK...	106	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000444009
P00736-297-unknown	GWKLRY...	297	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC705
P00736-464-unknown	IIGGQK...	464	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P00736-464-unknown	IIGGQK...	464	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC706
P00736-487-unknown	GGGALL...	487		unknown		Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...SKSGEE	154	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000444009
...YFCSCR	176	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000441601
...RPGYEL	181	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000445285
...SGDSRG	296	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC705
...YQLIEG	346	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000444271
...YQLIEG	346	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000438636
...YQLIEG	346	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000438682
...EQRQRI	463	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...EQRQRI	463	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC706
...MEEED	705	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
C1R_HUMAN	296	DSRG.\|.GWKL	inferred from experiment	unknown	MEROPS	Arlaud GJ	Lacroix M et al.:Structure and assembly of the c... (S01.192)	9174342,
C1R_HUMAN	463	RQRI.\|.IIGG	inferred from experiment	unknown	MEROPS	Arlaud GJ	Lacroix M et al.:Structure and assembly of the c... (S01.192)	9174342,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
C1R_HUMAN	296	DSRG.\|.GWKL	inferred from experiment	unknown	MEROPS	Arlaud GJ	Lacroix M et al.:Structure and assembly of the c... (S01.192)	9174342,
C1S_HUMAN	437	KQRI.\|.IIGG	inferred from experiment	unknown	MEROPS	Schumaker VN	Luo C et al.:Recombinant human complement su... (S01.192)	1533159,
C1R_HUMAN	463	RQRI.\|.IIGG	inferred from experiment	unknown	MEROPS	Arlaud GJ	Lacroix M et al.:Structure and assembly of the c... (S01.192)	9174342,
IC1_HUMAN	466	VART.\|.TLLV	inferred from experiment	unknown	MEROPS	Pike RN	Duncan RC et al.:The initiating proteases of the... (S01.192)	17850949,