P09871: Complement C1s subcomponent

General Information

Protein names	- Complement C1s subcomponent - 3.4.21.42 - C1 esterase - Complement component 1 subcomponent s - Complement C1s subcomponent heavy chain - Complement C1s subcomponent light chain
Gene names	C1S
Organism	Homo sapiens
Protease Family	S01.193
Protease ID	S01.193
Chromosome location
UniProt ID	P09871

4 N-termini

6 C-termini

1 Cleavages

6 Substrates

Sequence

        10         20         30         40         50         60
MWCIVLFSLL AWVYAEPTMY GEILSPNYPQ AYPSEVEKSW DIEVPEGYGI HLYFTHLDIE
        70         80         90        100        110        120
LSENCAYDSV QIISGDTEEG RLCGQRSSNN PHSPIVEEFQ VPYNKLQVIF KSDFSNEERF
       130        140        150        160        170        180
TGFAAYYVAT DINECTDFVD VPCSHFCNNF IGGYFCSCPP EYFLHDDMKN CGVNCSGDVF
       190        200        210        220        230        240
TALIGEIASP NYPKPYPENS RCEYQIRLEK GFQVVVTLRR EDFDVEAADS AGNCLDSLVF
       250        260        270        280        290        300
VAGDRQFGPY CGHGFPGPLN IETKSNALDI IFQTDLTGQK KGWKLRYHGD PMPCPKEDTP
       310        320        330        340        350        360
NSVWEPAKAK YVFRDVVQIT CLDGFEVVEG RVGATSFYST CQSNGKWSNS KLKCQPVDCG
       370        380        390        400        410        420
IPESIENGKV EDPESTLFGS VIRYTCEEPY YYMENGGGGE YHCAGNGSWV NEVLGPELPK
       430        440        450        460        470        480
CVPVCGVPRE PFEEKQRIIG GSDADIKNFP WQVFFDNPWA GGALINEYWV LTAAHVVEGN
       490        500        510        520        530        540
REPTMYVGST SVQTSRLAKS KMLTPEHVFI HPGWKLLEVP EGRTNFDNDI ALVRLKDPVK
       550        560        570        580        590        600
MGPTVSPICL PGTSSDYNLM DGDLGLISGW GRTEKRDRAV RLKAARLPVA PLRKCKEVKV
       610        620        630        640        650        660
EKPTADAEAY VFTPNMICAG GEKGMDSCKG DSGGAFAVQD PNDKTKFYAA GLVSWGPQCG
       670        680
TYGLYTRVKN YVDWIMKTMQ ENSTPRED

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

4 N-termini - 6 C-termini - 1 Cleavages - 6 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name	Publications (PMID)
P09871-16-unknown	EPTMYG...	16	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P09871-168-unknown	MKNCGV...	168	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000470828
P09871-168-unknown	MKNCGV...	168	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000470735
P09871-168-unknown	MKNCGV...	168	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000384171
P09871-168-unknown	MKNCGV...	168	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000442298
P09871-438-unknown	IIGGSD...	438	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P09871-438-unknown	IIGGSD...	438	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC708
P09871-438-unknown	IIGGSD...	438		unknown		Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P09871-584-unknown	AARLPV...	584		unknown		Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...VEEFQV	100	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000470421
...VEEFQV	100	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000399892
...FQVPYN	103	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000469643
...FQVPYN	103	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000406643
...LHDDMK	168	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000469552
...LHDDMK	168	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000384464
...TCLDGF	324	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000470735
...TCLDGF	324	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000442298
...EEKQRI	437	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...EEKQRI	437	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC708
...TPRED	688	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
C1R_HUMAN	437	KQRI.\|.IIGG	inferred from experiment	unknown	MEROPS	Schumaker VN	Luo C et al.:Recombinant human complement su... (S01.192)	1533159,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
B2MG_HUMAN	78	FSKD.\|.DWSF	inferred from experiment	unknown	MEROPS	Fothergill JE	Nissen MH et al.:Limited proteolysis of beta 2-m... (S01.193)	2110898,
CO2-Isoform3_HUMAN	111	LGRK.\|.KIQI	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC710
CO2_HUMAN	243	LGRK.\|.KIQI	inferred from experiment	unknown	MEROPS		Merops C1S_HUMAN -> CO2_HUMAN @243
IC1_HUMAN	466	VART.\|.TLLV	inferred from experiment	unknown	MEROPS	Pike RN	Duncan RC et al.:The initiating proteases of the... (S01.192)	17850949,
CO4A_HUMAN	756	LQRA.\|.ALEI	inferred from experiment	unknown	MEROPS	Tsiftsoglou SA	Sim RB et al.:Proteases of the complement sys... (S01.193)	14748705,
CO4A-Isoform2_HUMAN	756	LQRA.\|.ALEI	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC712