P05156: Complement factor I

General Information

Protein names	- Complement factor I - 3.4.21.45 - C3B/C4B inactivator - Complement factor I heavy chain - Complement factor I light chain
Gene names	CFI
Organism	Homo sapiens
Protease Family	S01.199
Protease ID	S01.199
Chromosome location
UniProt ID	P05156

14 N-termini

13 C-termini

10 Cleavages

6 Substrates

Sequence

        10         20         30         40         50         60
MKLLHVFLLF LCFHLRFCKV TYTSQEDLVE KKCLAKKYTH LSCDKVFCQP WQRCIEGTCV
        70         80         90        100        110        120
CKLPYQCPKN GTAVCATNRR SFPTYCQQKS LECLHPGTKF LNNGTCTAEG KFSVSLKHGN
       130        140        150        160        170        180
TDSEGIVEVK LVDQDKTMFI CKSSWSMREA NVACLDLGFQ QGADTQRRFK LSDLSINSTE
       190        200        210        220        230        240
CLHVHCRGLE TSLAECTFTK RRTMGYQDFA DVVCYTQKAD SPMDDFFQCV NGKYISQMKA
       250        260        270        280        290        300
CDGINDCGDQ SDELCCKACQ GKGFHCKSGV CIPSQYQCNG EVDCITGEDE VGCAGFASVT
       310        320        330        340        350        360
QEETEILTAD MDAERRRIKS LLPKLSCGVK NRMHIRRKRI VGGKRAQLGD LPWQVAIKDA
       370        380        390        400        410        420
SGITCGGIYI GGCWILTAAH CLRASKTHRY QIWTTVVDWI HPDLKRIVIE YVDRIIFHEN
       430        440        450        460        470        480
YNAGTYQNDI ALIEMKKDGN KKDCELPRSI PACVPWSPYL FQPNDTCIVS GWGREKDNER
       490        500        510        520        530        540
VFSLQWGEVK LISNCSKFYG NRFYEKEMEC AGTYDGSIDA CKGDSGGPLV CMDANNVTYV
       550        560        570        580
WGVVSWGENC GKPEFPGVYT KVANYFDWIS YHVGRPFISQ YNV

Isoforms

Sequence View

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name	Publications (PMID)
P05156-19-unknown	KVTYTS...	19	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P05156-19-unknown	KVTYTS...	19		unknown		Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P05156-21-unknown	TYTSQE...	21		unknown		Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P05156-22-unknown	YTSQED...	22		unknown		Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P05156-37-unknown	KYTHLS...	37	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27508
P05156-38-unknown	YTHLSC...	38	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27509
P05156-80-unknown	RSFPTY...	80	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27510
P05156-81-unknown	SFPTYC...	81		unknown		Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P05156-90-unknown	SLECLH...	90	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27511
P05156-171-unknown	LSDLSI...	171	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27512
P05156-258-unknown	ACQGKG...	258	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27513
P05156-320-unknown	SLLPKL...	320	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27514
P05156-340-unknown	IVGGKR...	340	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P05156-340-unknown	IVGGKR...	340	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27515
P05156-345-unknown	RAQLGD...	345	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27516
P05156-406-unknown	RIVIEY...	406	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27517

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...KCLAKK	36	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27508
...CLAKKY	37	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27509
...CATNRR	79	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27510
...YCQQKS	89	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27511
...LGFQQG	161	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000422009
...QRRFKL	170	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27512
...ELCCKA	257	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27513
...RRRIKS	319	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27514
...NRMHIR	335	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...IRRKRI	339	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27515
...IVGGKR	344	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27516
...HPDLKR	405	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27517
...SQYNV	583	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
PLMN_HUMAN	36	LAKK.\|.KYTH	inferred from experiment	unknown	MEROPS	Sim RB	Tsiftsoglou SA et al.:The catalytically active serine... (S01.233)	15835912,
PLMN_HUMAN	37	AKKY.\|.YTHL	inferred from experiment	unknown	MEROPS	Sim RB	Tsiftsoglou SA et al.:The catalytically active serine... (S01.233)	15835912,
PLMN_HUMAN	79	TNRR.\|.RSFP	inferred from experiment	unknown	MEROPS	Sim RB	Tsiftsoglou SA et al.:The catalytically active serine... (S01.233)	15835912,
PLMN_HUMAN	89	QQKS.\|.SLEC	inferred from experiment	unknown	MEROPS	Sim RB	Tsiftsoglou SA et al.:The catalytically active serine... (S01.233)	15835912,
PLMN_HUMAN	170	RFKL.\|.LSDL	inferred from experiment	unknown	MEROPS	Sim RB	Tsiftsoglou SA et al.:The catalytically active serine... (S01.233)	15835912,
PLMN_HUMAN	257	CCKA.\|.ACQG	inferred from experiment	unknown	MEROPS	Sim RB	Tsiftsoglou SA et al.:The catalytically active serine... (S01.233)	15835912,
PLMN_HUMAN	319	RIKS.\|.SLLP	inferred from experiment	unknown	MEROPS	Sim RB	Tsiftsoglou SA et al.:The catalytically active serine... (S01.233)	15835912,
PLMN_HUMAN	339	RKRI.\|.IVGG	inferred from experiment	unknown	MEROPS	Sim RB	Tsiftsoglou SA et al.:The catalytically active serine... (S01.233)	15835912,
PLMN_HUMAN	344	GGKR.\|.RAQL	inferred from experiment	unknown	MEROPS	Sim RB	Tsiftsoglou SA et al.:The catalytically active serine... (S01.233)	15835912,
PLMN_HUMAN	405	DLKR.\|.RIVI	inferred from experiment	unknown	MEROPS	Sim RB	Tsiftsoglou SA et al.:The catalytically active serine... (S01.233)	15835912,

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CO4A_HUMAN	956	RGRT.\|.TLEI	inferred from experiment	unknown	MEROPS		Merops CFAI_HUMAN -> CO4A_HUMAN @956
CO4A-Isoform2_HUMAN	956	RGRT.\|.TLEI	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC8359
CO3_HUMAN	1303	PSRS.\|.SSKI	inferred from experiment	unknown	MEROPS	Fey GH	de Bruijn MH et al.:Human complement component C3: ... (S01.199)	2579379,
CO3_HUMAN	1320	LLRS.\|.SEET	inferred from experiment	unknown	MEROPS	Fey GH	de Bruijn MH et al.:Human complement component C3: ... (S01.199)	2579379,
CO4A_HUMAN	1336	TGRN.\|.NGFK	inferred from experiment	unknown	MEROPS		Merops CFAI_HUMAN -> CO4A_HUMAN @1336
CO4A-Isoform2_HUMAN	1336	TGRN.\|.NGFK	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC8361

TopFIND

P05156: Complement factor I

General Information

14

N-termini

13

C-termini

10

Cleavages

6

Substrates

Sequence

Isoforms

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Protein Neighborhood

Domains & Features

14 N-termini - 13 C-termini - 10 Cleavages - 6 Substrates

N-termini

C-termini

Cleavages

Substrates