O60911: Cathepsin L2

General Information

Protein names	- Cathepsin L2 - 3.4.22.43 - Cathepsin U - Cathepsin V
Gene names	CTSV
Organism	Homo sapiens
Protease Family	C01.009
Protease ID	C01.009
Chromosome location
UniProt ID	O60911

4 N-termini

3 C-termini

2 Cleavages

9 Substrates

Sequence

        10         20         30         40         50         60
MNLSLVLAAF CLGIASAVPK FDQNLDTKWY QWKATHRRLY GANEEGWRRA VWEKNMKMIE
        70         80         90        100        110        120
LHNGEYSQGK HGFTMAMNAF GDMTNEEFRQ MMGCFRNQKF RKGKVFREPL FLDLPKSVDW
       130        140        150        160        170        180
RKKGYVTPVK NQKQCGSCWA FSATGALEGQ MFRKTGKLVS LSEQNLVDCS RPQGNQGCNG
       190        200        210        220        230        240
GFMARAFQYV KENGGLDSEE SYPYVAVDEI CKYRPENSVA NDTGFTVVAP GKEKALMKAV
       250        260        270        280        290        300
ATVGPISVAM DAGHSSFQFY KSGIYFEPDC SSKNLDHGVL VVGYGFEGAN SNNSKYWLVK
       310        320        330
NSWGPEWGSN GYVKIAKDKN NHCGIATAAS YPNV

Isoforms

Sequence View

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
O60911-18-unknown	VPKFDQ...	18	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
O60911-114-unknown	LPKSVD...	114	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
O60911-142-unknown	SATGAL...	142	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5219
O60911-143-unknown	ATGALE...	143	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5220

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...SCWAFS	141	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5219
...CWAFSA	142	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5220
...SYPNV	334	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATL1_HUMAN	141	WAFS.\|.SATG	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	142	AFSA.\|.ATGA	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
PLMN_HUMAN	94	VLFE.\|.EKKV	inferred from experiment	unknown	MEROPS	Carmona AK	Puzer L et al.:Cathepsin V, but not cathepsins... (C01.009)	18163891,
PENK_HUMAN	97	LLAK.\|.KRYG	inferred from experiment	unknown	MEROPS	Hook V	Funkelstein L et al.:Human cathepsin V protease part... (C01.009)	22393040,
PENK_HUMAN	104	GFMK.\|.KRYG	inferred from experiment	unknown	MEROPS	Hook V	Funkelstein L et al.:Human cathepsin V protease part... (C01.009)	22393040,
PENK_HUMAN	133	ILAK.\|.KRYG	inferred from experiment	unknown	MEROPS	Hook V	Funkelstein L et al.:Human cathepsin V protease part... (C01.009)	22393040,
PENK_HUMAN	207	ELQK.\|.KRYG	inferred from experiment	unknown	MEROPS	Hook V	Funkelstein L et al.:Human cathepsin V protease part... (C01.009)	22393040,
PENK_HUMAN	234	GFLK.\|.KRFA	inferred from experiment	unknown	MEROPS	Hook V	Funkelstein L et al.:Human cathepsin V protease part... (C01.009)	22393040,
PENK_HUMAN	235	FLKR.\|.RFAE	inferred from experiment	unknown	MEROPS	Hook V	Funkelstein L et al.:Human cathepsin V protease part... (C01.009)	22393040,
PLMN_HUMAN	358	PVST.\|.TEQL	inferred from experiment	unknown	MEROPS	Carmona AK	Puzer L et al.:Cathepsin V, but not cathepsins... (C01.009)	18163891,
PLMN_HUMAN	468	PVVL.\|.LLPD	inferred from experiment	unknown	MEROPS	Carmona AK	Puzer L et al.:Cathepsin V, but not cathepsins... (C01.009)	18163891,

TopFIND

O60911: Cathepsin L2

General Information

4

N-termini

3

C-termini

2

Cleavages

9

Substrates

Sequence

Isoforms

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Protein Neighborhood

Domains & Features

4 N-termini - 3 C-termini - 2 Cleavages - 9 Substrates

N-termini

C-termini

Cleavages

Substrates