P10645: Chromogranin-A

General Information

Protein names	- Chromogranin-A - CgA - Pituitary secretory protein I - SP-I - Vasostatin-1 - Vasostatin I - Vasostatin-2 - Vasostatin II - EA-92 - ES-43 - Pancreastatin - SS-18 - WA-8 - WE-14 - LF-19 - Catestatin {ECO:0000303\|PubMed:10781584, ECO:0000303\|PubMed:17991725} - SL21 {ECO:0000303\|PubMed:24723458} - AL-11 - GV-19 - GR-44 - ER-37 - GE-25 {ECO:0000303\|PubMed:7535395} - Serpinin-RRG - Serpinin - p-Glu serpinin precursor
Gene names	CHGA
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P10645

15 N-termini

12 C-termini

11 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MRSAAVLALL LCAGQVTALP VNSPMNKGDT EVMKCIVEVI SDTLSKPSPM PVSQECFETL
        70         80         90        100        110        120
RGDERILSIL RHQNLLKELQ DLALQGAKER AHQQKKHSGF EDELSEVLEN QSSQAELKEA
       130        140        150        160        170        180
VEEPSSKDVM EKREDSKEAE KSGEATDGAR PQALPEPMQE SKAEGNNQAP GEEEEEEEEA
       190        200        210        220        230        240
TNTHPPASLP SQKYPGPQAE GDSEGLSQGL VDREKGLSAE PGWQAKREEE EEEEEEAEAG
       250        260        270        280        290        300
EEAVPEEEGP TVVLNPHPSL GYKEIRKGES RSEALAVDGA GKPGAEEAQD PEGKGEQEHS
       310        320        330        340        350        360
QQKEEEEEMA VVPQGLFRGG KSGELEQEEE RLSKEWEDSK RWSKMDQLAK ELTAEKRLEG
       370        380        390        400        410        420
QEEEEDNRDS SMKLSFRARA YGFRGPGPQL RRGWRPSSRE DSLEAGLPLQ VRGYPEEKKE
       430        440        450
EEGSANRRPE DQELESLSAI EAELEKVAHQ LQALRRG

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

15 N-termini - 12 C-termini - 11 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name	Publications (PMID)
P10645-19-unknown	LPVNSP...	19	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P10645-21-unknown	VNSPMN...	21		unknown		Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P10645-305-unknown	EEEEMA...	305	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC236
P10645-306-unknown	EEEMAV...	306	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC237
P10645-307-unknown	EEMAVV...	307	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC238
P10645-308-unknown	EMAVVP...	308	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC239
P10645-309-unknown	MAVVPQ...	309	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC240
P10645-319-unknown	GGKSGE...	319		unknown		Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P10645-369-unknown	DSSMKL...	369	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27540
P10645-374-unknown	LSFRAR...	374	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27541
P10645-378-unknown	ARAYGF...	378	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27542
P10645-380-unknown	AYGFRG...	380	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27543
P10645-385-unknown	GPGPQL...	385	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27544
P10645-392-unknown	RGWRPS...	392	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27545
P10645-413-unknown	GYPEEK...	413		unknown		Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...SQQKEE	304	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC236
...QQKEEE	305	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC237
...QKEEEE	306	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC238
...KEEEEE	307	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC239
...EEEEEM	308	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC240
...EEDNRD	368	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27540
...DSSMKL	373	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27541
...KLSFRA	377	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27542
...SFRARA	379	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27543
...AYGFRG	384	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27544
...GPQLRR	391	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27545
...ALRRG	457	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
AMPE_HUMAN	304	QKEE.\|.EEEE	inferred from experiment	unknown	MEROPS	Tsujimoto M	Goto Y et al.:Enzymatic properties of human a... (M01.003)	16790432,
AMPE_HUMAN	305	KEEE.\|.EEEM	inferred from experiment	unknown	MEROPS	Tsujimoto M	Goto Y et al.:Enzymatic properties of human a... (M01.003)	16790432,
AMPE_HUMAN	306	EEEE.\|.EEMA	inferred from experiment	unknown	MEROPS	Tsujimoto M	Goto Y et al.:Enzymatic properties of human a... (M01.003)	16790432,
AMPE_HUMAN	307	EEEE.\|.EMAV	inferred from experiment	unknown	MEROPS	Tsujimoto M	Goto Y et al.:Enzymatic properties of human a... (M01.003)	16790432,
AMPE_HUMAN	308	EEEM.\|.MAVV	inferred from experiment	unknown	MEROPS	Tsujimoto M	Goto Y et al.:Enzymatic properties of human a... (M01.003)	16790432,
PLMN_HUMAN	368	DNRD.\|.DSSM	inferred from experiment	unknown	MEROPS	Traynelis SF	Yuan H et al.:The serine protease plasmin cle... (S01.233)	19240037,
PLMN_HUMAN	373	SMKL.\|.LSFR	inferred from experiment	unknown	MEROPS	Traynelis SF	Yuan H et al.:The serine protease plasmin cle... (S01.233)	19240037,
PLMN_HUMAN	377	SFRA.\|.ARAY	inferred from experiment	unknown	MEROPS	Parmer RJ	Jiang Q et al.:Proteolytic cleavage of chromog... (S01.233)	11342539,
PLMN_HUMAN	379	RARA.\|.AYGF	inferred from experiment	unknown	MEROPS	Traynelis SF	Yuan H et al.:The serine protease plasmin cle... (S01.233)	19240037,
PLMN_HUMAN	384	GFRG.\|.GPGP	inferred from experiment	unknown	MEROPS	Traynelis SF	Yuan H et al.:The serine protease plasmin cle... (S01.233)	19240037,
PLMN_HUMAN	391	QLRR.\|.RGWR	inferred from experiment	unknown	MEROPS	Parmer RJ	Jiang Q et al.:Proteolytic cleavage of chromog... (S01.233)	11342539,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)