P00450: Ceruloplasmin

General Information

Protein names	- Ceruloplasmin - 1.16.3.1 - Ferroxidase
Gene names	CP
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P00450

9 N-termini

4 C-termini

2 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MKILILGIFL FLCSTPAWAK EKHYYIGIIE TTWDYASDHG EKKLISVDTE HSNIYLQNGP
        70         80         90        100        110        120
DRIGRLYKKA LYLQYTDETF RTTIEKPVWL GFLGPIIKAE TGDKVYVHLK NLASRPYTFH
       130        140        150        160        170        180
SHGITYYKEH EGAIYPDNTT DFQRADDKVY PGEQYTYMLL ATEEQSPGEG DGNCVTRIYH
       190        200        210        220        230        240
SHIDAPKDIA SGLIGPLIIC KKDSLDKEKE KHIDREFVVM FSVVDENFSW YLEDNIKTYC
       250        260        270        280        290        300
SEPEKVDKDN EDFQESNRMY SVNGYTFGSL PGLSMCAEDR VKWYLFGMGN EVDVHAAFFH
       310        320        330        340        350        360
GQALTNKNYR IDTINLFPAT LFDAYMVAQN PGEWMLSCQN LNHLKAGLQA FFQVQECNKS
       370        380        390        400        410        420
SSKDNIRGKH VRHYYIAAEE IIWNYAPSGI DIFTKENLTA PGSDSAVFFE QGTTRIGGSY
       430        440        450        460        470        480
KKLVYREYTD ASFTNRKERG PEEEHLGILG PVIWAEVGDT IRVTFHNKGA YPLSIEPIGV
       490        500        510        520        530        540
RFNKNNEGTY YSPNYNPQSR SVPPSASHVA PTETFTYEWT VPKEVGPTNA DPVCLAKMYY
       550        560        570        580        590        600
SAVDPTKDIF TGLIGPMKIC KKGSLHANGR QKDVDKEFYL FPTVFDENES LLLEDNIRMF
       610        620        630        640        650        660
TTAPDQVDKE DEDFQESNKM HSMNGFMYGN QPGLTMCKGD SVVWYLFSAG NEADVHGIYF
       670        680        690        700        710        720
SGNTYLWRGE RRDTANLFPQ TSLTLHMWPD TEGTFNVECL TTDHYTGGMK QKYTVNQCRR
       730        740        750        760        770        780
QSEDSTFYLG ERTYYIAAVE VEWDYSPQRE WEKELHHLQE QNVSNAFLDK GEFYIGSKYK
       790        800        810        820        830        840
KVVYRQYTDS TFRVPVERKA EEEHLGILGP QLHADVGDKV KIIFKNMATR PYSIHAHGVQ
       850        860        870        880        890        900
TESSTVTPTL PGETLTYVWK IPERSGAGTE DSACIPWAYY STVDQVKDLY SGLIGPLIVC
       910        920        930        940        950        960
RRPYLKVFNP RRKLEFALLF LVFDENESWY LDDNIKTYSD HPEKVNKDDE EFIESNKMHA
       970        980        990       1000       1010       1020
INGRMFGNLQ GLTMHVGDEV NWYLMGMGNE IDLHTVHFHG HSFQYKHRGV YSSDVFDIFP
      1030       1040       1050       1060
GTYQTLEMFP RTPGIWLLHC HVTDHIHAGM ETTYTVLQNE DTKSG

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

9 N-termini - 4 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name	Publications (PMID)
P00450-20-unknown	KEKHYY...	20	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P00450-218-unknown	VVMFSV...	218	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000420545
P00450-360-unknown	SSSKDN...	360		unknown		Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P00450-501-unknown	SVPPSA...	501	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27431
P00450-725-unknown	STFYLG...	725		unknown		Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P00450-866-unknown	GAGTED...	866	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000420367
P00450-902-unknown	RPYLKV...	902		unknown		Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P00450-903-unknown	PYLKVF...	903		unknown		Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P00450-907-unknown	VFNPRR...	907	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27432

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...IYPDNT	138	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000426888
...NPQSRS	500	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27431
...RPYLKV	906	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27432
...DTKSG	1065	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
PLMN_HUMAN	500	QSRS.\|.SVPP	inferred from experiment	unknown	MEROPS	Putnam FW	Kingston IB et al.:Chemical evidence that proteoly... (S01.233)	146197,
PLMN_HUMAN	906	YLKV.\|.VFNP	inferred from experiment	unknown	MEROPS	Putnam FW	Kingston IB et al.:Chemical evidence that proteoly... (S01.233)	146197,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)