P10915: Hyaluronan and proteoglycan link protein 1

General Information

Protein names	- Hyaluronan and proteoglycan link protein 1 - Cartilage-linking protein 1 - Cartilage-link protein - Proteoglycan link protein
Gene names	HAPLN1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P10915

12 N-termini

17 C-termini

20 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MKSLLLLVLI SICWADHLSD NYTLDHDRAI HIQAENGPHL LVEAEQAKVF SHRGGNVTLP
        70         80         90        100        110        120
CKFYRDPTAF GSGIHKIRIK WTKLTSDYLK EVDVFVSMGY HKKTYGGYQG RVFLKGGSDS
       130        140        150        160        170        180
DASLVITDLT LEDYGRYKCE VIEGLEDDTV VVALDLQGVV FPYFPRLGRY NLNFHEAQQA
       190        200        210        220        230        240
CLDQDAVIAS FDQLYDAWRG GLDWCNAGWL SDGSVQYPIT KPREPCGGQN TVPGVRNYGF
       250        260        270        280        290        300
WDKDKSRYDV FCFTSNFNGR FYYLIHPTKL TYDEAVQACL NDGAQIAKVG QIFAAWKILG
       310        320        330        340        350
YDRCDAGWLA DGSVRYPISR PRRRCSPTEA AVRFVGFPDK KHKLYGVYCF RAYN

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

12 N-termini - 17 C-termini - 20 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
P10915-16-unknown	DHLSDN...	16	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P10915-29-unknown	AIHIQA...	29	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27546
P10915-32-unknown	IQAENG...	32	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC23869
P10915-32-unknown	IQAENG...	32	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC25674
P10915-32-unknown	IQAENG...	32	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC22672
P10915-32-unknown	IQAENG...	32	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19939
P10915-32-unknown	IQAENG...	32	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21742
P10915-33-unknown	QAENGP...	33	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9344
P10915-34-unknown	AENGPH...	34	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3612
P10915-34-unknown	AENGPH...	34	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4807
P10915-35-unknown	ENGPHL...	35	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3613
P10915-40-unknown	LLVEAE...	40	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8345
P10915-41-unknown	LVEAEQ...	41	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3614
P10915-41-unknown	LVEAEQ...	41	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC22673
P10915-41-unknown	LVEAEQ...	41	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC24030
P10915-41-unknown	LVEAEQ...	41	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19940
P10915-42-unknown	VEAEQA...	42	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8346
P10915-42-unknown	VEAEQA...	42	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4576
P10915-43-unknown	EAEQAK...	43	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5546
P10915-44-unknown	AEQAKV...	44	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5547
P10915-72-unknown	SGIHKI...	72	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5548

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...LDHDRA	28	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27546
...DRAIHI	31	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC23869
...DRAIHI	31	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC25674
...DRAIHI	31	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC22672
...DRAIHI	31	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19939
...DRAIHI	31	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21742
...RAIHIQ	32	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9344
...AIHIQA	33	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3612
...AIHIQA	33	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4807
...IHIQAE	34	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3613
...ENGPHL	39	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8345
...NGPHLL	40	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3614
...NGPHLL	40	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC22673
...NGPHLL	40	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC24030
...NGPHLL	40	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19940
...GPHLLV	41	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8346
...GPHLLV	41	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4576
...PHLLVE	42	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5546
...HLLVEA	43	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5547
...PTAFGS	71	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5548
...TVVVAL	153	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000423836
...LDLQGV	158	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000422522
...QACLDQ	183	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000426610
...YDAWRG	199	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000421341
...TSNFNG	258	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000422592
...FRAYN	354	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
PLMN_HUMAN	28	HDRA.\|.AIHI	inferred from experiment	unknown	MEROPS		Merops PLMN_HUMAN -> HPLN1_HUMAN @28
MMP3_HUMAN	31	AIHI.\|.IQAE	inferred from experiment	unknown	MEROPS	Roughley PJ	Nguyen Q et al.:Matrix metalloproteinases cleav... (M10.006)	7694569,
MMP9_HUMAN	31	AIHI.\|.IQAE	inferred from experiment	unknown	MEROPS	Roughley PJ	Nguyen Q et al.:Matrix metalloproteinases cleav... (M10.006)	7694569,
MMP2_HUMAN	31	AIHI.\|.IQAE	inferred from experiment	unknown	MEROPS	Roughley PJ	Nguyen Q et al.:Matrix metalloproteinases cleav... (M10.006)	7694569,
MMP10_HUMAN	31	AIHI.\|.IQAE	inferred from experiment	unknown	MEROPS	Roughley PJ	Nguyen Q et al.:Matrix metalloproteinases cleav... (M10.006)	7694569,
MMP1_HUMAN	31	AIHI.\|.IQAE	inferred from experiment	unknown	MEROPS	Roughley PJ	Nguyen Q et al.:Matrix metalloproteinases cleav... (M10.006)	7694569,
ELNE_HUMAN	32	IHIQ.\|.QAEN	inferred from experiment	unknown	MEROPS		Merops ELNE_HUMAN -> HPLN1_HUMAN @32
ELNE_HUMAN	32	IHIQ.\|.QAEN	inferred from experiment	unknown	MEROPS	Mort JS	Nguyen Q et al.:Link protein as a monitor in si... (A01.009)	1883326,
CATB_HUMAN	33	HIQA.\|.AENG	inferred from experiment	unknown	MEROPS	Roughley PJ	Nguyen Q et al.:Cartilage proteoglycan aggregat... (C01.060)	2317204,
CATG_HUMAN	33	HIQA.\|.AENG	inferred from experiment	unknown	MEROPS		Merops CATG_HUMAN -> HPLN1_HUMAN @33
CATG_HUMAN	33	HIQA.\|.AENG	inferred from experiment	unknown	MEROPS	Mort JS	Nguyen Q et al.:Link protein as a monitor in si... (S01.133)	1883326,
CATB_HUMAN	34	IQAE.\|.ENGP	inferred from experiment	unknown	MEROPS	Roughley PJ	Nguyen Q et al.:Cartilage proteoglycan aggregat... (C01.060)	2317204,
CELA1_HUMAN	39	GPHL.\|.LLVE	inferred from experiment	unknown	MEROPS		Merops CELA1_HUMAN -> HPLN1_HUMAN @39
CELA1_HUMAN	39	GPHL.\|.LLVE	inferred from experiment	unknown	MEROPS	Mort JS	Nguyen Q et al.:Link protein as a monitor in si... (A01.009)	1883326,
CATB_HUMAN	40	PHLL.\|.LVEA	inferred from experiment	unknown	MEROPS	Roughley PJ	Nguyen Q et al.:Cartilage proteoglycan aggregat... (C01.060)	2317204,
MMP2_HUMAN	40	PHLL.\|.LVEA	inferred from experiment	unknown	MEROPS	Roughley PJ	Nguyen Q et al.:Matrix metalloproteinases cleav... (M10.006)	7694569,
MMP7_HUMAN	40	PHLL.\|.LVEA	inferred from experiment	unknown	MEROPS	Roughley PJ	Nguyen Q et al.:Matrix metalloproteinases cleav... (M10.006)	7694569,
MMP10_HUMAN	40	PHLL.\|.LVEA	inferred from experiment	unknown	MEROPS	Roughley PJ	Nguyen Q et al.:Matrix metalloproteinases cleav... (M10.006)	7694569,
CELA1_HUMAN	41	HLLV.\|.VEAE	inferred from experiment	unknown	MEROPS		Merops CELA1_HUMAN -> HPLN1_HUMAN @41
CELA1_HUMAN	41	HLLV.\|.VEAE	inferred from experiment	unknown	MEROPS	Mort JS	Nguyen Q et al.:Link protein as a monitor in si... (A01.009)	1883326,
CATD_HUMAN	41	HLLV.\|.VEAE	inferred from experiment	unknown	MEROPS		Merops CATD_HUMAN -> HPLN1_HUMAN @41
CATD_HUMAN	41	HLLV.\|.VEAE	inferred from experiment	unknown	MEROPS	Mort JS	Nguyen Q et al.:Link protein as a monitor in si... (A01.009)	1883326,
CATL1_HUMAN	42	LLVE.\|.EAEQ	inferred from experiment	unknown	MEROPS	Roughley PJ	Nguyen Q et al.:Cartilage proteoglycan aggregat... (C01.060)	2317204,
CATL1_HUMAN	43	LVEA.\|.AEQA	inferred from experiment	unknown	MEROPS	Roughley PJ	Nguyen Q et al.:Cartilage proteoglycan aggregat... (C01.060)	2317204,
CATL1_HUMAN	71	AFGS.\|.SGIH	inferred from experiment	unknown	MEROPS	Roughley PJ	Nguyen Q et al.:Cartilage proteoglycan aggregat... (C01.060)	2317204,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)