P09238: Stromelysin-2
Protein names | - Stromelysin-2 - SL-2 - 3.4.24.22 - Matrix metalloproteinase-10 - MMP-10 - Transin-2 |
---|---|
Gene names | MMP10 |
Organism | Homo sapiens |
Protease Family | M10.006 |
Protease ID | M10.006 |
Chromosome location | |
UniProt ID | P09238 |
2
N-termini
1
C-termini
0
Cleavages
16
Substrates
Sequence
10 20 30 40 50 60
MMHLAFLVLL CLPVCSAYPL SGAAKEEDSN KDLAQQYLEK YYNLEKDVKQ FRRKDSNLIV
70 80 90 100 110 120
KKIQGMQKFL GLEVTGKLDT DTLEVMRKPR CGVPDVGHFS SFPGMPKWRK THLTYRIVNY
130 140 150 160 170 180
TPDLPRDAVD SAIEKALKVW EEVTPLTFSR LYEGEADIMI SFAVKEHGDF YSFDGPGHSL
190 200 210 220 230 240
AHAYPPGPGL YGDIHFDDDE KWTEDASGTN LFLVAAHELG HSLGLFHSAN TEALMYPLYN
250 260 270 280 290 300
SFTELAQFRL SQDDVNGIQS LYGPPPASTE EPLVPTKSVP SGSEMPAKCD PALSFDAIST
310 320 330 340 350 360
LRGEYLFFKD RYFWRRSHWN PEPEFHLISA FWPSLPSYLD AAYEVNSRDT VFIFKGNEFW
370 380 390 400 410 420
AIRGNEVQAG YPRGIHTLGF PPTIRKIDAA VSDKEKKKTY FFAADKYWRF DENSQSMEQG
430 440 450 460 470
FPRLIADDFP GVEPKVDAVL QAFGFFYFFS GSSQFEFDPN ARMVTHILKS NSWLHC
Isoforms
Sequence View
Protein Neighborhood
Domains & Features
2 N-termini - 1 C-termini - 0 Cleavages - 16 Substrates
N-termini
Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
---|---|---|---|---|---|---|---|---|---|
P09238-18-unknown | YPLSGA... | 18 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
P09238-99-unknown | FSSFPG... | 99 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot |
C-termini
Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
...SWLHC | 476 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot |
Cleavages
Protease | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|
Substrates
Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
HPLN1_HUMAN | 31 | AIHI.|.IQAE | inferred from experiment | unknown | MEROPS | Roughley PJ | Nguyen Q et al.:Matrix metalloproteinases cleav... (M10.006) | 7694569, |
HPLN1_HUMAN | 40 | PHLL.|.LVEA | inferred from experiment | unknown | MEROPS | Roughley PJ | Nguyen Q et al.:Matrix metalloproteinases cleav... (M10.006) | 7694569, |
MMP8_HUMAN | 98 | SGGF.|.FMLT | inferred from experiment | unknown | MEROPS | Tschesche H | Knauper V et al.:Activation of human neutrophil ... (M10.006) | 8631328, |
MMP9_HUMAN | 106 | LGRF.|.FQTF | inferred from experiment | unknown | MEROPS | Okada Y | Nakamura H et al.:Activation of the precursor of ... (M10.006) | 9578462, |
MBP-Isoform5_HUMAN | 111 | GLSL.|.LSRF | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC19931 | ||
MBP-Isoform3_HUMAN | 137 | GLSL.|.LSRF | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC19931 | ||
MBP-Isoform6_HUMAN | 158 | PMAR.|.RR | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC19934 | ||
MBP-Isoform5_HUMAN | 169 | PMAR.|.RR | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC19934 | ||
MBP-Isoform4_HUMAN | 184 | PMAR.|.RR | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC19934 | ||
MBP-Isoform3_HUMAN | 195 | PMAR.|.RR | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC19934 | ||
MBP_HUMAN | 244 | GLSL.|.LSRF | inferred from experiment | unknown | MEROPS | Strongin AY | Shiryaev SA et al.:Matrix metalloproteinase proteo... (M10.006) | 19300513, |
MBP_HUMAN | 302 | PMAR.|.RR | inferred from experiment | unknown | MEROPS | Strongin AY | Shiryaev SA et al.:Matrix metalloproteinase proteo... (M10.006) | 19300513, |
PGCA-Isoform3_HUMAN | 360 | PENF.|.FFGV | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC19942 | ||
PGCA-Isoform2_HUMAN | 360 | PENF.|.FFGV | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC19942 | ||
PGCA_HUMAN | 360 | PENF.|.FFGV | inferred from experiment | unknown | MEROPS | Hamilton JA | Fosang AJ et al.:Cleavage of cartilage proteogly... (M10.006) | 1874716, |
HD_HUMAN | 402 | GIGQ.|.QLTA | inferred from experiment | unknown | MEROPS | Ellerby LM | Miller JP et al.:Matrix metalloproteinases are m... (M10.006) | 20670829, |