Q12879: Glutamate receptor ionotropic, NMDA 2A
Protein names | - Glutamate receptor ionotropic, NMDA 2A - GluN2A - Glutamate NMDA] receptor subunit epsilon-1 - N-methyl D-aspartate receptor subtype 2A - NMDAR2A {ECO:0000303|PubMed:8768735} - NR2A - hNR2A {ECO:0000303|PubMed:8061049} |
---|---|
Gene names | GRIN2A |
Organism | Homo sapiens |
Protease Family | |
Protease ID | |
Chromosome location | |
UniProt ID | Q12879 |
4
N-termini
3
C-termini
2
Cleavages
0
Substrates
Sequence
10 20 30 40 50 60
MGRVGYWTLL VLPALLVWRG PAPSAAAEKG PPALNIAVML GHSHDVTERE LRTLWGPEQA
70 80 90 100 110 120
AGLPLDVNVV ALLMNRTDPK SLITHVCDLM SGARIHGLVF GDDTDQEAVA QMLDFISSHT
130 140 150 160 170 180
FVPILGIHGG ASMIMADKDP TSTFFQFGAS IQQQATVMLK IMQDYDWHVF SLVTTIFPGY
190 200 210 220 230 240
REFISFVKTT VDNSFVGWDM QNVITLDTSF EDAKTQVQLK KIHSSVILLY CSKDEAVLIL
250 260 270 280 290 300
SEARSLGLTG YDFFWIVPSL VSGNTELIPK EFPSGLISVS YDDWDYSLEA RVRDGIGILT
310 320 330 340 350 360
TAASSMLEKF SYIPEAKASC YGQMERPEVP MHTLHPFMVN VTWDGKDLSF TEEGYQVHPR
370 380 390 400 410 420
LVVIVLNKDR EWEKVGKWEN HTLSLRHAVW PRYKSFSDCE PDDNHLSIVT LEEAPFVIVE
430 440 450 460 470 480
DIDPLTETCV RNTVPCRKFV KINNSTNEGM NVKKCCKGFC IDILKKLSRT VKFTYDLYLV
490 500 510 520 530 540
TNGKHGKKVN NVWNGMIGEV VYQRAVMAVG SLTINEERSE VVDFSVPFVE TGISVMVSRS
550 560 570 580 590 600
NGTVSPSAFL EPFSASVWVM MFVMLLIVSA IAVFVFEYFS PVGYNRNLAK GKAPHGPSFT
610 620 630 640 650 660
IGKAIWLLWG LVFNNSVPVQ NPKGTTSKIM VSVWAFFAVI FLASYTANLA AFMIQEEFVD
670 680 690 700 710 720
QVTGLSDKKF QRPHDYSPPF RFGTVPNGST ERNIRNNYPY MHQYMTKFNQ KGVEDALVSL
730 740 750 760 770 780
KTGKLDAFIY DAAVLNYKAG RDEGCKLVTI GSGYIFATTG YGIALQKGSP WKRQIDLALL
790 800 810 820 830 840
QFVGDGEMEE LETLWLTGIC HNEKNEVMSS QLDIDNMAGV FYMLAAAMAL SLITFIWEHL
850 860 870 880 890 900
FYWKLRFCFT GVCSDRPGLL FSISRGIYSC IHGVHIEEKK KSPDFNLTGS QSNMLKLLRS
910 920 930 940 950 960
AKNISSMSNM NSSRMDSPKR AADFIQRGSL IMDMVSDKGN LMYSDNRSFQ GKESIFGDNM
970 980 990 1000 1010 1020
NELQTFVANR QKDNLNNYVF QGQHPLTLNE SNPNTVEVAV STESKANSRP RQLWKKSVDS
1030 1040 1050 1060 1070 1080
IRQDSLSQNP VSQRDEATAE NRTHSLKSPR YLPEEMAHSD ISETSNRATC HREPDNSKNH
1090 1100 1110 1120 1130 1140
KTKDNFKRSV ASKYPKDCSE VERTYLKTKS SSPRDKIYTI DGEKEPGFHL DPPQFVENVT
1150 1160 1170 1180 1190 1200
LPENVDFPDP YQDPSENFRK GDSTLPMNRN PLHNEEGLSN NDQYKLYSKH FTLKDKGSPH
1210 1220 1230 1240 1250 1260
SETSERYRQN STHCRSCLSN MPTYSGHFTM RSPFKCDACL RMGNLYDIDE DQMLQETGNP
1270 1280 1290 1300 1310 1320
ATGEQVYQQD WAQNNALQLQ KNKLRISRQH SYDNIVDKPR ELDLSRPSRS ISLKDRERLL
1330 1340 1350 1360 1370 1380
EGNFYGSLFS VPSSKLSGKK SSLFPQGLED SKRSKSLLPD HTSDNPFLHS HRDDQRLVIG
1390 1400 1410 1420 1430 1440
RCPSDPYKHS LPSQAVNDSY LRSSLRSTAS YCSRDSRGHN DVYISEHVMP YAANKNNMYS
1450 1460
TPRVLNSCSN RRVYKKMPSI ESDV
Isoforms
- Isoform 2 of Glutamate receptor ionotropic, NMDA 2ASequence View
10 20 30 40 50 60
MGRVGYWTLL VLPALLVWRG PAPSAAAEKG PPALNIAVML GHSHDVTERE LRTLWGPEQA
70 80 90 100 110 120
AGLPLDVNVV ALLMNRTDPK SLITHVCDLM SGARIHGLVF GDDTDQEAVA QMLDFISSHT
130 140 150 160 170 180
FVPILGIHGG ASMIMADKDP TSTFFQFGAS IQQQATVMLK IMQDYDWHVF SLVTTIFPGY
190 200 210 220 230 240
REFISFVKTT VDNSFVGWDM QNVITLDTSF EDAKTQVQLK KIHSSVILLY CSKDEAVLIL
250 260 270 280 290 300
SEARSLGLTG YDFFWIVPSL VSGNTELIPK EFPSGLISVS YDDWDYSLEA RVRDGIGILT
310 320 330 340 350 360
TAASSMLEKF SYIPEAKASC YGQMERPEVP MHTLHPFMVN VTWDGKDLSF TEEGYQVHPR
370 380 390 400 410 420
LVVIVLNKDR EWEKVGKWEN HTLSLRHAVW PRYKSFSDCE PDDNHLSIVT LEEAPFVIVE
430 440 450 460 470 480
DIDPLTETCV RNTVPCRKFV KINNSTNEGM NVKKCCKGFC IDILKKLSRT VKFTYDLYLV
490 500 510 520 530 540
TNGKHGKKVN NVWNGMIGEV VYQRAVMAVG SLTINEERSE VVDFSVPFVE TGISVMVSRS
550 560 570 580 590 600
NGTVSPSAFL EPFSASVWVM MFVMLLIVSA IAVFVFEYFS PVGYNRNLAK GKAPHGPSFT
610 620 630 640 650 660
IGKAIWLLWG LVFNNSVPVQ NPKGTTSKIM VSVWAFFAVI FLASYTANLA AFMIQEEFVD
670 680 690 700 710 720
QVTGLSDKKF QRPHDYSPPF RFGTVPNGST ERNIRNNYPY MHQYMTKFNQ KGVEDALVSL
730 740 750 760 770 780
KTGKLDAFIY DAAVLNYKAG RDEGCKLVTI GSGYIFATTG YGIALQKGSP WKRQIDLALL
790 800 810 820 830 840
QFVGDGEMEE LETLWLTGIC HNEKNEVMSS QLDIDNMAGV FYMLAAAMAL SLITFIWEHL
850 860 870 880 890 900
FYWKLRFCFT GVCSDRPGLL FSISRGIYSC IHGVHIEEKK KSPDFNLTGS QSNMLKLLRS
910 920 930 940 950 960
AKNISSMSNM NSSRMDSPKR AADFIQRGSL IMDMVSDKGN LMYSDNRSFQ GKESIFGDNM
970 980 990 1000 1010 1020
NELQTFVANR QKDNLNNYVF QGQHPLTLNE SNPNTVEVAV STESKANSRP RQLWKKSVDS
1030 1040 1050 1060 1070 1080
IRQDSLSQNP VSQRDEATAE NRTHSLKSPR YLPEEMAHSD ISETSNRATC HREPDNSKNH
1090 1100 1110 1120 1130 1140
KTKDNFKRSV ASKYPKDCSE VERTYLKTKS SSPRDKIYTI DGEKEPGFHL DPPQFVENVT
1150 1160 1170 1180 1190 1200
LPENVDFPDP YQDPSENFRK GDSTLPMNRN PLHNEEGLSN NDQYKLYSKH FTLKDKGSPH
1210 1220 1230 1240 1250 1260
SETSERYRQN STHCRSCLSN MPTYSGHFTM RSPFKCDACL RMGNLYDIDE DQMLQETGNP
1270 1280 1290 1300 1310 1320
ATGEQVYQQD WAQNNALQLQ KNKLRISRQH SYDNIVDKPR ELDLSRPSRS ISLKDRERLL
1330 1340 1350 1360 1370 1380
EGNFYGSLFS VPSSKLSGKK SSLFPQGLED SKRSKSLLPD HTSDNPFLHS HRDDQRLVIG
1390 1400 1410 1420 1430 1440
RCPSDPYKHS LPSQAVNDSY LRSSLRSTAS YCSRDSRGHN DVYISEHVMP YAANKNNMYS
1450 1460
TPRVLNSCSN RRVYKKMPSI ESDV
Protein Neighborhood
Domains & Features
4 N-termini - 3 C-termini - 2 Cleavages - 0 Substrates
N-termini
Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
---|---|---|---|---|---|---|---|---|---|
Q12879-1-unknown | MGRVGY... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt82965 | |||
Q12879-23-unknown | PSAAAE... | 23 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
Q12879-23-unknown | PSAAAE... | 23 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt113258 | |||
Q12879-318-unknown | ASCYGQ... | 318 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC27600 | |||
Q12879-318-unknown | ASCYGQ... | 318 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt150293 | |||
Q12879-1399-unknown | SYLRSS... | 1399 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC11966 |
C-termini
Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
...IPEAKA | 317 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC27600 | |||
...IPEAKA | 317 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt133688 | |||
...QAVNDS | 1398 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC11966 | |||
...IESDV | 1464 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot |
Cleavages
Protease | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
PLMN_HUMAN | 317 | EAKA.|.ASCY | inferred from experiment | unknown | MEROPS | Traynelis SF | Yuan H et al.:The serine protease plasmin cle... (S01.233) | 19240037, |
GRAB_HUMAN | 1398 | VNDS.|.SYLR | inferred from experiment | unknown | MEROPS | Rogers SW | Gahring L et al.:Granzyme B proteolysis of a neu... (S01.010) | 11160179, |
Substrates
Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
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