P31948: Stress-induced-phosphoprotein 1

General Information

Protein names	- Stress-induced-phosphoprotein 1 - STI1 - Hsc70/Hsp90-organizing protein - Hop - Renal carcinoma antigen NY-REN-11 - Transformation-sensitive protein IEF SSP 3521
Gene names	STIP1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P31948

17 N-termini

12 C-termini

14 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Stress-induced-phosphoprotein 1 - Isoform 3 of Stress-induced-phosphoprotein 1

Sequence View

        10         20         30         40         50         60
MEQVNELKEK GNKALSVGNI DDALQCYSEA IKLDPHNHVL YSNRSAAYAK KGDYQKAYED
        70         80         90        100        110        120
GCKTVDLKPD WGKGYSRKAA ALEFLNRFEE AKRTYEEGLK HEANNPQLKE GLQNMEARLA
       130        140        150        160        170        180
ERKFMNPFNM PNLYQKLESD PRTRTLLSDP TYRELIEQLR NKPSDLGTKL QDPRIMTTLS
       190        200        210        220        230        240
VLLGVDLGSM DEEEEIATPP PPPPPKKETK PEPMEEDLPE NKKQALKEKE LGNDAYKKKD
       250        260        270        280        290        300
FDTALKHYDK AKELDPTNMT YITNQAAVYF EKGDYNKCRE LCEKAIEVGR ENREDYRQIA
       310        320        330        340        350        360
KAYARIGNSY FKEEKYKDAI HFYNKSLAEH RTPDVLKKCQ QAEKILKEQE RLAYINPDLA
       370        380        390        400        410        420
LEEKNKGNEC FQKGDYPQAM KHYTEAIKRN PKDAKLYSNR AACYTKLLEF QLALKDCEEC
       430        440        450        460        470        480
IQLEPTFIKG YTRKAAALEA MKDYTKAMDV YQKALDLDSS CKEAADGYQR CMMAQYNRHD
       490        500        510        520        530        540
SPEDVKRRAM ADPEVQQIMS DPAMRLILEQ MQKDPQALSE HLKNPVIAQK IQKLMDVGLI

AIR         10         20         30         40         50         60
MEQVNELKEK GNKALSVGNI DDALQCYSEA IKLDPHNHVL YSNRSAAYAK KGDYQKAYED
        70         80         90        100        110        120
GCKTVDLKPD WGKGYSRKAA ALEFLNRFEE AKRTYEEGLK HEANNPQLKE GLQNMEARLA
       130        140        150        160        170        180
ERKFMNPFNM PNLYQKLESD PRTRTLLSDP TYRELIEQLR NKPSDLGTKL QDPRIMTTLS
       190        200        210        220        230        240
VLLGVDLGSM DEEEEIATPP PPPPPKKETK PEPMEEDLPE NKKQALKEKE LGNDAYKKKD
       250        260        270        280        290        300
FDTALKHYDK AKELDPTNMT YITNQAAVYF EKGDYNKCRE LCEKAIEVGR ENREDYRQIA
       310        320        330        340        350        360
KAYARIGNSY FKEEKYKDAI HFYNKSLAEH RTPDVLKKCQ QAEKILKEQE RLAYINPDLA
       370        380        390        400        410        420
LEEKNKGNEC FQKGDYPQAM KHYTEAIKRN PKDAKLYSNR AACYTKLLEF QLALKDCEEC
       430        440        450        460        470        480
IQLEPTFIKG YTRKAAALEA MKDYTKAMDV YQKALDLDSS CKEAADGYQR CMMAQYNRHD
       490        500        510        520        530        540
SPEDVKRRAM ADPEVQQIMS DPAMRLILEQ MQKDPQALSE HLKNPVIAQK IQKLMDVGLI

AIR

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

17 N-termini - 12 C-termini - 14 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name
P31948-1-Acetylation	MEQVNE...	1	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P31948-1-Acetylation	MEQVNE...	1	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
P31948-1-Acetylation	MEQVNE...	1	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P31948-19-unknown	NIDDAL...	19		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5801
P31948-29-unknown	EAIKLD...	29		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19052
P31948-96-unknown	EEGLKH...	96		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19053
P31948-96-unknown	EEGLKH...	96		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17596
P31948-97-unknown	EGLKHE...	97		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19054
P31948-98-unknown	GLKHEA...	98		inferred from electronic annotation	unknown	TISdb		inferred from TISdb
P31948-187-unknown	LGSMDE...	187		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11443
P31948-280-Pyrrolidone carboxylic acid (Glu)	ELCEKA...	280	pyrrolidone carboxylic acid-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P31948-280-acetylation	ELCEKA...	280	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P31948-355-unknown	INPDLA...	355		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17597
P31948-380-unknown	MKHYTE...	380		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19055
P31948-402-unknown	ACYTKL...	402		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000443416
P31948-421-unknown	IQLEPT...	421		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19966
P31948-449-unknown	DVYQKA...	449		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19056
P31948-449-unknown	DVYQKA...	449		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17598
P31948-456-unknown	DLDSSC...	456		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19057
P31948-456-unknown	DLDSSC...	456		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17599
P31948-495-acetylation	VQQIMS...	495	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P31948-520-unknown	EHLKNP...	520		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19058

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...ALSVGN	18	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5801
...LQCYSE	28	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19052
...AKRTYE	95	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19053
...AKRTYE	95	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17596
...KRTYEE	96	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19054
...LLGVDL	186	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11443
...ERLAYI	354	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17597
...DYPQAM	379	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19055
...DCEECI	420	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19966
...YTKAMD	448	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19056
...YTKAMD	448	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17598
...YQKALD	455	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19057
...YQKALD	455	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17599
...PQALSE	519	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19058
...LIAIR	543	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATL1_HUMAN	18	SVGN.\|.NIDD	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
MEP1B_HUMAN	28	CYSE.\|.EAIK	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	95	RTYE.\|.EEGL	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	95	RTYE.\|.EEGL	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	96	TYEE.\|.EGLK	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
GRAB_HUMAN	186	GVDL.\|.LGSM	inferred from experiment	unknown	MEROPS	Ley TJ	Bredemeyer AJ et al.:Hop cleavage and function in gr... (S01.010)	17005566,
MEP1A_HUMAN	354	LAYI.\|.INPD	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	379	PQAM.\|.MKHY	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MMP11_HUMAN	420	EECI.\|.IQLE	inferred from experiment	unknown	MEROPS		Merops MMP11_HUMAN -> STIP1_HUMAN @420
MEP1B_HUMAN	448	KAMD.\|.DVYQ	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	448	KAMD.\|.DVYQ	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	455	KALD.\|.DLDS	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	455	KALD.\|.DLDS	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	519	ALSE.\|.EHLK	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)