P08238: Heat shock protein HSP 90-beta

General Information

Protein names	- Heat shock protein HSP 90-beta - HSP 90 - Heat shock 84 kDa - HSP 84 - HSP84
Gene names	HSP90AB1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P08238

51 N-termini

20 C-termini

28 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MPEEVHHGEE EVETFAFQAE IAQLMSLIIN TFYSNKEIFL RELISNASDA LDKIRYESLT
        70         80         90        100        110        120
DPSKLDSGKE LKIDIIPNPQ ERTLTLVDTG IGMTKADLIN NLGTIAKSGT KAFMEALQAG
       130        140        150        160        170        180
ADISMIGQFG VGFYSAYLVA EKVVVITKHN DDEQYAWESS AGGSFTVRAD HGEPIGRGTK
       190        200        210        220        230        240
VILHLKEDQT EYLEERRVKE VVKKHSQFIG YPITLYLEKE REKEISDDEA EEEKGEKEEE
       250        260        270        280        290        300
DKDDEEKPKI EDVGSDEEDD SGKDKKKKTK KIKEKYIDQE ELNKTKPIWT RNPDDITQEE
       310        320        330        340        350        360
YGEFYKSLTN DWEDHLAVKH FSVEGQLEFR ALLFIPRRAP FDLFENKKKK NNIKLYVRRV
       370        380        390        400        410        420
FIMDSCDELI PEYLNFIRGV VDSEDLPLNI SREMLQQSKI LKVIRKNIVK KCLELFSELA
       430        440        450        460        470        480
EDKENYKKFY EAFSKNLKLG IHEDSTNRRR LSELLRYHTS QSGDEMTSLS EYVSRMKETQ
       490        500        510        520        530        540
KSIYYITGES KEQVANSAFV ERVRKRGFEV VYMTEPIDEY CVQQLKEFDG KSLVSVTKEG
       550        560        570        580        590        600
LELPEDEEEK KKMEESKAKF ENLCKLMKEI LDKKVEKVTI SNRLVSSPCC IVTSTYGWTA
       610        620        630        640        650        660
NMERIMKAQA LRDNSTMGYM MAKKHLEINP DHPIVETLRQ KAEADKNDKA VKDLVVLLFE
       670        680        690        700        710        720
TALLSSGFSL EDPQTHSNRI YRMIKLGLGI DEDEVAAEEP NAAVPDEIPP LEGDEDASRM

EEVD

Isoforms

Sequence View

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Protease Assignment Confidence:

Evidence Names:

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Protein Neighborhood

Domains & Features

51 N-termini - 20 C-termini - 28 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P08238-2-unknown	PEEVHH...	2	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P08238-42-unknown	ELISNA...	42	inferred from electronic annotation	unknown	TISdb		inferred from TISdb
P08238-46-unknown	NASDAL...	46	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7251
P08238-46-unknown	NASDAL...	46	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5503
P08238-58-unknown	SLTDPS...	58	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18596
P08238-84-	LTLVDT...	84		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P08238-84-	LTLVDT...	84		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P08238-159-	SSAGGS...	159		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P08238-159-	SSAGGS...	159		Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
P08238-160-	SAGGSF...	160		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P08238-160-	SAGGSF...	160		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P08238-160-	SAGGSF...	160		Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
P08238-160-	SAGGSF...	160		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P08238-163-unknown	GSFTVR...	163	inferred from electronic annotation	unknown	TISdb		inferred from TISdb
P08238-184-	HLKEDQ...	184		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P08238-185-unknown	LKEDQT...	185	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5504
P08238-205-	HSQFIG...	205		Subtiligase Based Positive Selection		Wells	apoptotic_RPMI_Dox	23264352
P08238-210-	GYPITL...	210		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P08238-210-	GYPITL...	210		Subtiligase Based Positive Selection		Wells	THP_untreated	23264352
P08238-260-unknown	DSGKDK...	260	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1608
P08238-276-	YIDQEE...	276		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P08238-295-unknown	DITQEE...	295	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17221
P08238-307-	SLTNDW...	307		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P08238-307-	SLTNDW...	307		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P08238-307-	SLTNDW...	307		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P08238-307-	SLTNDW...	307		Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
P08238-307-	SLTNDW...	307		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P08238-307-	SLTNDW...	307		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P08238-311-unknown	DWEDHL...	311	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17222
P08238-311-unknown	DWEDHL...	311	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5505
P08238-322-	SVEGQL...	322		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P08238-322-	SVEGQL...	322		Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
P08238-323-unknown	VEGQLE...	323	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7252
P08238-323-unknown	VEGQLE...	323	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5506
P08238-339-unknown	APFDLF...	339		unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P08238-339-	APFDLF...	339		Subtiligase Based Positive Selection		Wells	DB_Untreated	23264352
P08238-339-	APFDLF...	339		Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
P08238-339-	APFDLF...	339		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
P08238-339-	APFDLF...	339		Subtiligase Based Positive Selection		Wells	apoptotic_RPMI_Dox	23264352
P08238-339-	APFDLF...	339		Subtiligase Based Positive Selection		Wells	RMPI_untreated	23264352
P08238-379-	GVVDSE...	379		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P08238-379-	GVVDSE...	379		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P08238-379-	GVVDSE...	379		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P08238-383-	SEDLPL...	383		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P08238-418-unknown	ELAEDK...	418	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7253
P08238-418-unknown	ELAEDK...	418	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5507
P08238-457-	YHTSQS...	457		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P08238-457-	YHTSQS...	457		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P08238-457-	YHTSQS...	457		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P08238-458-	HTSQSG...	458		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P08238-482-	SIYYIT...	482		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P08238-482-	SIYYIT...	482		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P08238-492-unknown	EQVANS...	492	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18597
P08238-532-	SLVSVT...	532		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P08238-605-unknown	IMKAQA...	605	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13941
P08238-610-	ALRDNS...	610		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
P08238-615-	STMGYM...	615		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P08238-622-unknown	AKKHLE...	622	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13942
P08238-624-	KHLEIN...	624		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P08238-625-	HLEINP...	625		Subtiligase Based Positive Selection		Wells	apoptotic_RPMI_Dox	23264352
P08238-626-unknown	LEINPD...	626	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17223
P08238-627-unknown	EINPDH...	627		unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P08238-627-	EINPDH...	627		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
P08238-627-	EINPDH...	627		Subtiligase Based Positive Selection		Wells	apopotic_Jurkat_FasL	23264352
P08238-628-unknown	INPDHP...	628	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17224
P08238-628-unknown	INPDHP...	628	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7254
P08238-628-unknown	INPDHP...	628	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5508
P08238-628-unknown	INPDHP...	628	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18598
P08238-631-unknown	DHPIVE...	631	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17225
P08238-631-unknown	DHPIVE...	631	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18599
P08238-632-unknown	HPIVET...	632	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17226
P08238-632-unknown	HPIVET...	632	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11117
P08238-662-	ALLSSG...	662		Subtiligase Based Positive Selection		Wells	THP_untreated	23264352
P08238-663-unknown	LLSSGF...	663	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19952
P08238-664-unknown	LSSGFS...	664	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3540
P08238-667-	GFSLED...	667		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
P08238-694-unknown	EVAAEE...	694	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11118
P08238-695-	VAAEEP...	695		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P08238-697-	AEEPNA...	697		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P08238-702-	AAVPDE...	702		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P08238-702-	AAVPDE...	702		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P08238-702-	AAVPDE...	702		Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
P08238-702-	AAVPDE...	702		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P08238-702-	AAVPDE...	702		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P08238-703-	AVPDEI...	703		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P08238-703-	AVPDEI...	703		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P08238-703-	AVPDEI...	703		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P08238-703-	AVPDEI...	703		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P08238-707-unknown	EIPPLE...	707	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3217

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...RELISN	45	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7251
...RELISN	45	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5503
...KIRYES	57	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18596
...KVILHL	184	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5504
...SDEEDD	259	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1608
...TRNPDD	294	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17221
...KSLTND	310	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17222
...KSLTND	310	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5505
...VKHFSV	322	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7252
...VKHFSV	322	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5506
...LELFSE	417	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7253
...LELFSE	417	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5507
...TGESKE	491	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18597
...ANMERI	604	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13941
...MGYMMA	621	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13942
...MAKKHL	625	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17223
...KKHLEI	627	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17224
...KKHLEI	627	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7254
...KKHLEI	627	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5508
...KKHLEI	627	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18598
...LEINPD	630	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17225
...LEINPD	630	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18599
...EINPDH	631	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17226
...EINPDH	631	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11117
...LFETAL	662	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19952
...FETALL	663	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3540
...GIDEDE	693	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11118
...AAVPDE	706	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3217
...MEEVD	724	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATS_HUMAN	45	LISN.\|.NASD	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	45	LISN.\|.NASD	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
MEP1B_HUMAN	57	RYES.\|.SLTD	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
CATL1_HUMAN	184	ILHL.\|.LKED	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CASP3_HUMAN	259	EEDD.\|.DSGK	inferred from experiment	unknown	MEROPS	Liu R	Ju W et al.:Proteome-wide identification of... (C14.003)	17728405,
MEP1A_HUMAN	294	NPDD.\|.DITQ	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	310	LTND.\|.DWED	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
CATL1_HUMAN	310	LTND.\|.DWED	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATS_HUMAN	322	HFSV.\|.VEGQ	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	322	HFSV.\|.VEGQ	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATS_HUMAN	417	LFSE.\|.ELAE	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	417	LFSE.\|.ELAE	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
MEP1B_HUMAN	491	ESKE.\|.EQVA	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
GRAM_HUMAN	604	MERI.\|.IMKA	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
GRAM_HUMAN	621	YMMA.\|.AKKH	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
MEP1A_HUMAN	625	KKHL.\|.LEIN	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	627	HLEI.\|.INPD	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
CATS_HUMAN	627	HLEI.\|.INPD	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	627	HLEI.\|.INPD	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
MEP1B_HUMAN	627	HLEI.\|.INPD	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	630	INPD.\|.DHPI	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	630	INPD.\|.DHPI	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	631	NPDH.\|.HPIV	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
GRAB_HUMAN	631	NPDH.\|.HPIV	inferred from experiment	unknown	MEROPS	Craik CS	Hostetter DR et al.:Hip is a pro-survival substrate... (S01.010)	17620340,
MMP11_HUMAN	662	ETAL.\|.LLSS	inferred from experiment	unknown	MEROPS		Merops MMP11_HUMAN -> HS90B_HUMAN @662
CATB_HUMAN	663	TALL.\|.LSSG	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
GRAB_HUMAN	693	DEDE.\|.EVAA	inferred from experiment	unknown	MEROPS	Craik CS	Hostetter DR et al.:Hip is a pro-survival substrate... (S01.010)	17620340,
CASPE_HUMAN	706	VPDE.\|.EIPP	inferred from experiment	unknown	MEROPS		Merops CASPE_HUMAN -> HS90B_HUMAN @706

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)