TopFIND 4.0

P63220: 40S ribosomal protein S21

General Information

Protein names	- 40S ribosomal protein S21 - Small ribosomal subunit protein eS21 {ECO:0000303\|PubMed:24524803}
Gene names	RPS21
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P63220

7

N-termini

6

C-termini

6

Cleavages

0

Substrates

Sequence

10 20 30 40 50 60
MQNDAGEFVD LYVPRKCSAS NRIIGAKDHA SIQMNVAEVD KVTGRFNGQF KTYAICGAIR
70 80
RMGESDDSIL RLAKADGIVS KNF

Isoforms

Sequence View

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Evidence Codes:

Methodology:

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Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

7 N-termini - 6 C-termini - 6 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P63220-1-Acetylation	MQNDAG...	1	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P63220-1-Acetylation	MQNDAG...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
P63220-1-Acetylation	MQNDAG...	1	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
P63220-1-Acetylation	MQNDAG...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
P63220-8-unknown	FVDLYV...	8		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19973
P63220-23-	IIGAKD...	23			Subtiligase Based Positive Selection		Wells	apoptotic_RPMI_Dox	23264352
P63220-31-	SIQMNV...	31			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P63220-35-unknown	NVAEVD...	35		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19279
P63220-35-unknown	NVAEVD...	35		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17800
P63220-35-unknown	NVAEVD...	35		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7662
P63220-35-	NVAEVD...	35			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P63220-35-	NVAEVD...	35			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P63220-35-	NVAEVD...	35			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P63220-35-	NVAEVD...	35			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P63220-36-unknown	VAEVDK...	36		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19280
P63220-36-unknown	VAEVDK...	36		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17801

C-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
	...NDAGEF	7	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19973
	...ASIQMN	34	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19279
	...ASIQMN	34	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17800
	...ASIQMN	34	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7662
	...SIQMNV	35	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19280
	...SIQMNV	35	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17801
	...GIVSKN	81	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000388332
	...VSKNF	83	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
	...VSKNF	83		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
	...VSKNF	83		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,
	...VSKNF	83		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
	...VSKNF	83		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MMP11_HUMAN	7	AGEF.\|.FVDL	inferred from experiment	unknown	MEROPS		Merops MMP11_HUMAN -> RS21_HUMAN @7
MEP1B_HUMAN	34	IQMN.\|.NVAE	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	34	IQMN.\|.NVAE	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
CATS_HUMAN	34	IQMN.\|.NVAE	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
MEP1B_HUMAN	35	QMNV.\|.VAEV	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	35	QMNV.\|.VAEV	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)