O75886: Signal transducing adapter molecule 2

General Information

Protein names	- Signal transducing adapter molecule 2 - STAM-2 - Hrs-binding protein
Gene names	STAM2
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	O75886

5 N-termini

3 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MPLFTANPFE QDVEKATNEY NTTEDWSLIM DICDKVGSTP NGAKDCLKAI MKRVNHKVPH
        70         80         90        100        110        120
VALQALTLLG ACVANCGKIF HLEVCSRDFA TEVRAVIKNK AHPKVCEKLK SLMVEWSEEF
       130        140        150        160        170        180
QKDPQFSLIS ATIKSMKEEG ITFPPAGSQT VSAAAKNGTS SNKNKEDEDI AKAIELSLQE
       190        200        210        220        230        240
QKQQHTETKS LYPSSEIQLN NKVARKVRAL YDFEAVEDNE LTFKHGEIII VLDDSDANWW
       250        260        270        280        290        300
KGENHRGIGL FPSNFVTTNL NIETEAAAVD KLNVIDDDVE EIKKSEPEPV YIDEDKMDRA
       310        320        330        340        350        360
LQVLQSIDPT DSKPDSQDLL DLEDICQQMG PMIDEKLEEI DRKHSELSEL NVKVLEALEL
       370        380        390        400        410        420
YNKLVNEAPV YSVYSKLHPP AHYPPASSGV PMQTYPVQSH GGNYMGQSIH QVTVAQSYSL
       430        440        450        460        470        480
GPDQIGPLRS LPPNVNSSVT AQPAQTSYLS TGQDTVSNPT YMNQNSNLQS ATGTTAYTQQ
       490        500        510        520
MGMSVDMSSY QNTTSNLPQL AGFPVTVPAH PVAQQHTNYH QQPLL

Isoforms

- Isoform 2 of Signal transducing adapter molecule 2

Sequence View

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Protein Neighborhood

Domains & Features

5 N-termini - 3 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
O75886-1-unknown	MPLFTA...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O75886-1-unknown	MPLFTA...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt90862
O75886-3-	LFTANP...	3		Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
O75886-3-unknown	LFTANP...	3	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt165991
O75886-418-unknown	YSLGPD...	418	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19947
O75886-419-	SLGPDQ...	419		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
O75886-419-	SLGPDQ...	419		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
O75886-419-	SLGPDQ...	419		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
O75886-419-	SLGPDQ...	419		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
O75886-419-	SLGPDQ...	419		Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
O75886-419-	SLGPDQ...	419		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
O75886-419-	SLGPDQ...	419		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...EEIDRK	342	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt86480
...TVAQSY	417	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19947
...QQPLL	525	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MMP11_HUMAN	417	AQSY.\|.YSLG	inferred from experiment	unknown	MEROPS		Merops MMP11_HUMAN -> STAM2_HUMAN @417

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)