P62736: Actin, aortic smooth muscle

General Information

Protein names	- Actin, aortic smooth muscle - Alpha-actin-2 - Cell growth-inhibiting gene 46 protein - Actin, aortic smooth muscle, intermediate form
Gene names	ACTA2
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P62736

14 N-termini

14 C-termini

13 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MCEEEDSTAL VCDNGSGLCK AGFAGDDAPR AVFPSIVGRP RHQGVMVGMG QKDSYVGDEA
        70         80         90        100        110        120
QSKRGILTLK YPIEHGIITN WDDMEKIWHH SFYNELRVAP EEHPTLLTEA PLNPKANREK
       130        140        150        160        170        180
MTQIMFETFN VPAMYVAIQA VLSLYASGRT TGIVLDSGDG VTHNVPIYEG YALPHAIMRL
       190        200        210        220        230        240
DLAGRDLTDY LMKILTERGY SFVTTAEREI VRDIKEKLCY VALDFENEMA TAASSSSLEK
       250        260        270        280        290        300
SYELPDGQVI TIGNERFRCP ETLFQPSFIG MESAGIHETT YNSIMKCDID IRKDLYANNV
       310        320        330        340        350        360
LSGGTTMYPG IADRMQKEIT ALAPSTMKIK IIAPPERKYS VWIGGSILAS LSTFQQMWIS
       370
KQEYDEAGPS IVHRKCF

Isoforms

Sequence View

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P62736-3-Acetylation	EEEDST...	3	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P62736-3-Acetylation	EEEDST...	3	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
P62736-3-Acetylation	EEEDST...	3	acetylation-	inferred from similarity	unknown	UniProtKB		inferred from uniprot (by similarity)
P62736-5-	EDSTAL...	5			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P62736-14-unknown	NGSGLC...	14		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11774
P62736-20-unknown	KAGFAG...	20		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC15331
P62736-21-unknown	AGFAGD...	21		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10134
P62736-23-unknown	FAGDDA...	23		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3887
P62736-50-unknown	GQKDSY...	50		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14258
P62736-50-unknown	GQKDSY...	50		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P62736-50-unknown	GQKDSY...	50		inferred from similarity	unknown	UniProtKB		inferred from uniprot (by similarity)
P62736-54-unknown	SYVGDE...	54		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1971
P62736-54-unknown	SYVGDE...	54		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11775
P62736-75-unknown	HGIITN...	75		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6125
P62736-107-unknown	LTEAPL...	107		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19970
P62736-108-unknown	TEAPLN...	108		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC15332
P62736-109-unknown	EAPLNP...	109		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC15333
P62736-219-unknown	CYVALD...	219		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14259
P62736-238-unknown	LEKSYE...	238		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19971

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...ALVCDN	13	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11774
...GSGLCK	19	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15331
...SGLCKA	20	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10134
...LCKAGF	22	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3887
...VMVGMG	49	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14258
...MGQKDS	53	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1971
...MGQKDS	53	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11775
...KYPIEH	74	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6125
...EHPTLL	106	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19970
...HPTLLT	107	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15332
...PTLLTE	108	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15333
...SGRTTG	151	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000398239
...SGRTTG	151	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000396730
...IKEKLC	218	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14259
...ASSSSL	237	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19971
...HRKCF	377	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	13	VCDN.\|.NGSG	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,
HTRA2_HUMAN	19	GLCK.\|.KAGF	inferred from experiment	unknown	MEROPS	Vandenabeele P	Vande Walle L et al.:Proteome-wide Identification of... (S01.278)	17266347,
GRAA_HUMAN	20	LCKA.\|.AGFA	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:The substrate specificity profi... (S01.135)	20536382,
CATB_HUMAN	22	KAGF.\|.FAGD	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
GRAM_HUMAN	49	VGMG.\|.GQKD	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
CASP3_HUMAN	53	QKDS.\|.SYVG	inferred from experiment	unknown	MEROPS	Vandenabeele P	Demon D et al.:Proteome-wide substrate analysi... (C14.003)	19759058,
GRAB_HUMAN	53	QKDS.\|.SYVG	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,
CATL1_HUMAN	74	PIEH.\|.HGII	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
MMP11_HUMAN	106	PTLL.\|.LTEA	inferred from experiment	unknown	MEROPS		Merops MMP11_HUMAN -> ACTA_HUMAN @106
HTRA2_HUMAN	107	TLLT.\|.TEAP	inferred from experiment	unknown	MEROPS	Vandenabeele P	Vande Walle L et al.:Proteome-wide Identification of... (S01.278)	17266347,
HTRA2_HUMAN	108	LLTE.\|.EAPL	inferred from experiment	unknown	MEROPS	Vandenabeele P	Vande Walle L et al.:Proteome-wide Identification of... (S01.278)	17266347,
GRAM_HUMAN	218	EKLC.\|.CYVA	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
MMP11_HUMAN	237	SSSL.\|.LEKS	inferred from experiment	unknown	MEROPS		Merops MMP11_HUMAN -> ACTA_HUMAN @237

TopFIND

P62736: Actin, aortic smooth muscle

General Information

14

N-termini

14

C-termini

13

Cleavages

0

Substrates

Sequence

Isoforms

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Protein Neighborhood

Domains & Features

14 N-termini - 14 C-termini - 13 Cleavages - 0 Substrates

N-termini

C-termini

Cleavages

Substrates