P54725: UV excision repair protein RAD23 homolog A

General Information

Protein names	- UV excision repair protein RAD23 homolog A - HR23A - hHR23A
Gene names	RAD23A
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P54725

41 N-termini

5 C-termini

4 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of UV excision repair protein RAD23 homolog A - Isoform 3 of UV excision repair protein RAD23 homolog A

Sequence View

        10         20         30         40         50         60
MAVTITLKTL QQQTFKIRME PDETVKVLKE KIEAEKGRDA FPVAGQKLIY AGKILSDDVP
        70         80         90        100        110        120
IRDYRIDEKN FVVVMVTKTK AGQGTSAPPE ASPTAAPESS TSFPPAPTSG MSHPPPAARE
       130        140        150        160        170        180
DKSPSEESAP TTSPESVSGS VPSSGSSGRE EDAASTLVTG SEYETMLTEI MSMGYERERV
       190        200        210        220        230        240
VAALRASYNN PHRAVEYLLT GIPGSPEPEH GSVQESQVSE QPATEAAGEN PLEFLRDQPQ
       250        260        270        280        290        300
FQNMRQVIQQ NPALLPALLQ QLGQENPQLL QQISRHQEQF IQMLNEPPGE LADISDVEGE
       310        320        330        340        350        360
VGAIGEEAPQ MNYIQVTPQE KEAIERLKAL GFPESLVIQA YFACEKNENL AANFLLSQNF

DDE         10         20         30         40         50         60
MAVTITLKTL QQQTFKIRME PDETVKVLKE KIEAEKGRDA FPVAGQKLIY AGKILSDDVP
        70         80         90        100        110        120
IRDYRIDEKN FVVVMVTKTK AGQGTSAPPE ASPTAAPESS TSFPPAPTSG MSHPPPAARE
       130        140        150        160        170        180
DKSPSEESAP TTSPESVSGS VPSSGSSGRE EDAASTLVTG SEYETMLTEI MSMGYERERV
       190        200        210        220        230        240
VAALRASYNN PHRAVEYLLT GIPGSPEPEH GSVQESQVSE QPATEAAGEN PLEFLRDQPQ
       250        260        270        280        290        300
FQNMRQVIQQ NPALLPALLQ QLGQENPQLL QQISRHQEQF IQMLNEPPGE LADISDVEGE
       310        320        330        340        350        360
VGAIGEEAPQ MNYIQVTPQE KEAIERLKAL GFPESLVIQA YFACEKNENL AANFLLSQNF

DDE

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(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

41 N-termini - 5 C-termini - 4 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P54725-1-unknown	MAVTIT...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P54725-1-unknown	MAVTIT...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt87220
P54725-1-unknown	MAVTIT...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt87221
P54725-19-unknown	MEPDET...	19		inferred from electronic annotation	unknown	TISdb		inferred from TISdb
P54725-19-unknown	MEPDET...	19		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt195160
P54725-19-unknown	MEPDET...	19		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt195161
P54725-102-	SFPPAP...	102			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P54725-102-unknown	SFPPAP...	102		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt168317
P54725-102-unknown	SFPPAP...	102		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt168318
P54725-112-acetylation	SHPPPA...	112	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P54725-112-acetylation	SHPPPA...	112	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt182781
P54725-112-acetylation	SHPPPA...	112	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt182782
P54725-122-unknown	KSPSEE...	122		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt182784
P54725-122-unknown	KSPSEE...	122		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt182785
P54725-122-	KSPSEE...	122			N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P54725-123-	SPSEES...	123			N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P54725-123-unknown	SPSEES...	123		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt182787
P54725-123-unknown	SPSEES...	123		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt182788
P54725-125-	SEESAP...	125			N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P54725-125-unknown	SEESAP...	125		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt182790
P54725-125-unknown	SEESAP...	125		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt182791
P54725-127-	ESAPTT...	127			N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P54725-127-unknown	ESAPTT...	127		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt182793
P54725-127-unknown	ESAPTT...	127		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt182794
P54725-128-	SAPTTS...	128			N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P54725-128-unknown	SAPTTS...	128		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt182796
P54725-128-unknown	SAPTTS...	128		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt182797
P54725-131-	TTSPES...	131			N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P54725-131-unknown	TTSPES...	131		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt182799
P54725-131-unknown	TTSPES...	131		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt182800
P54725-132-	TSPESV...	132			N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P54725-132-unknown	TSPESV...	132		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt182802
P54725-132-unknown	TSPESV...	132		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt182803
P54725-133-	SPESVS...	133			N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P54725-133-unknown	SPESVS...	133		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt182805
P54725-133-unknown	SPESVS...	133		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt182806
P54725-136-	SVSGSV...	136			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P54725-136-	SVSGSV...	136			N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P54725-136-unknown	SVSGSV...	136		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt175960
P54725-136-unknown	SVSGSV...	136		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt175961
P54725-139-unknown	GSVPSS...	139		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6032
P54725-139-unknown	GSVPSS...	139		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt144261
P54725-139-unknown	GSVPSS...	139		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt144262
P54725-205-	SPEPEH...	205			N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P54725-205-unknown	SPEPEH...	205		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt182808
P54725-205-unknown	SPEPEH...	205		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt182809
P54725-210-unknown	HGSVQE...	210		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11690
P54725-210-unknown	HGSVQE...	210		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt146960
P54725-212-unknown	SVQESQ...	212		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt175958
P54725-212-	SVQESQ...	212			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P54725-218-	VSEQPA...	218			N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P54725-218-unknown	VSEQPA...	218		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt182811
P54725-219-	SEQPAT...	219			N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P54725-219-unknown	SEQPAT...	219		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt182813
P54725-224-	TEAAGE...	224			N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P54725-224-unknown	TEAAGE...	224		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt182815
P54725-237-acetylation	DQPQFQ...	237	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P54725-237-acetylation	DQPQFQ...	237	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt182817
P54725-237-acetylation	DQPQFQ...	237	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt182818
P54725-264-acetylation	QENPQL...	264	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P54725-264-acetylation	QENPQL...	264	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt182820
P54725-301-unknown	VGAIGE...	301		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11693
P54725-301-unknown	VGAIGE...	301		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt149870
P54725-303-	AIGEEA...	303			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P54725-303-unknown	AIGEEA...	303		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt175963
P54725-313-unknown	YIQVTP...	313		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19967
P54725-313-unknown	YIQVTP...	313		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt150146

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...PESVSG	138	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6032
...PESVSG	138	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt127516
...PESVSG	138	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt127517
...SPEPEH	209	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11690
...SPEPEH	209	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt130291
...SPEPEH	209	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt130292
...DVEGEV	300	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11693
...DVEGEV	300	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt133261
...APQMNY	312	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19967
...APQMNY	312	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt133539
...NFDDE	363	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...NFDDE	363	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt82838
...NFDDE	363	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt82839

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATL1_HUMAN	138	SVSG.\|.GSVP	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
GRAB_HUMAN	209	EPEH.\|.HGSV	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,
GRAB_HUMAN	300	EGEV.\|.VGAI	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
MMP11_HUMAN	312	QMNY.\|.YIQV	inferred from experiment	unknown	MEROPS		Merops MMP11_HUMAN -> RD23A_HUMAN @312

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)