TopFIND 4.0

P08833: Insulin-like growth factor-binding protein 1

General Information

Protein names	- Insulin-like growth factor-binding protein 1 - IBP-1 - IGF-binding protein 1 - IGFBP-1 - Placental protein 12 - PP12
Gene names	IGFBP1
Organism	Homo sapiens
Protease Family
Protease ID	I31.951
Chromosome location
UniProt ID	P08833

4 N-termini

5 C-termini

9 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MSEVPVARVW LVLLLLTVQV GVTAGAPWQC APCSAEKLAL CPPVSASCSE VTRSAGCGCC
        70         80         90        100        110        120
PMCALPLGAA CGVATARCAR GLSCRALPGE QQPLHALTRG QGACVQESDA SAPHAAEAGS
       130        140        150        160        170        180
PESPESTEIT EEELLDNFHL MAPSEEDHSI LWDAISTYDG SKALHVTNIK KWKEPCRIEL
       190        200        210        220        230        240
YRVVESLAKA QETSGEEISK FYLPNCNKNG FYHSRQCETS MDGEAGLCWC VYPWNGKRIP
       250
GSPEIRGDPN CQIYFNVQN

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

4 N-termini - 5 C-termini - 9 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
P08833-26-unknown	APWQCA...	26	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P08833-26-unknown	APWQCA...	26	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16444
P08833-163-unknown	ALHVTN...	163	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16445
P08833-166-unknown	VTNIKK...	166	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC23650
P08833-166-unknown	VTNIKK...	166	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31610
P08833-166-unknown	VTNIKK...	166	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21885
P08833-166-unknown	VTNIKK...	166	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC23949
P08833-166-unknown	VTNIKK...	166	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19957
P08833-171-unknown	KWKEPC...	171	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC25103
P08833-171-unknown	KWKEPC...	171	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC23651

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...GVTAGA	25	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16444
...YDGSKA	162	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16445
...SKALHV	165	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC23650
...SKALHV	165	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31610
...SKALHV	165	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21885
...SKALHV	165	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC23949
...SKALHV	165	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19957
...VTNIKK	170	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC25103
...VTNIKK	170	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC23651
...FNVQN	259	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
KLK5_HUMAN	25	TAGA.\|.APWQ	inferred from experiment	unknown	MEROPS	Diamandis EP	Michael IP et al.:Human tissue kallikrein 5 is a ... (S01.017)	16517595,
KLK5_HUMAN	162	GSKA.\|.ALHV	inferred from experiment	unknown	MEROPS	Diamandis EP	Michael IP et al.:Human tissue kallikrein 5 is a ... (S01.017)	16517595,
MMP3_HUMAN	165	ALHV.\|.VTNI	inferred from experiment	unknown	MEROPS	Martinez-A C	Manes S et al.:Identification of insulin-like ... (M10.007)	9325295,
ST14_HUMAN	165	ALHV.\|.VTNI	inferred from experiment	unknown	MEROPS	Uhland K	Uhland K et al.:Matriptase and its putative rol... (S01.302)	17131055,
MMP26_HUMAN	165	ALHV.\|.VTNI	inferred from experiment	unknown	MEROPS	Sang QX	Park HI et al.:Peptide substrate specificities... (M10.029)	12119297,
MMP7_HUMAN	165	ALHV.\|.VTNI	inferred from experiment	unknown	MEROPS	Martinez-A C	Manes S et al.:Identification of insulin-like ... (M10.007)	9325295,
MMP11_HUMAN	165	ALHV.\|.VTNI	inferred from experiment	unknown	MEROPS	Martinez-A C	Manes S et al.:Identification of insulin-like ... (M10.007)	9325295,
MMP9_HUMAN	170	NIKK.\|.KWKE	inferred from experiment	unknown	MEROPS	Westwood M	Coppock HA et al.:Matrix metalloprotease-3 and -9... (M10.005)	15070833,
MMP3_HUMAN	170	NIKK.\|.KWKE	inferred from experiment	unknown	MEROPS	Westwood M	Coppock HA et al.:Matrix metalloprotease-3 and -9... (M10.005)	15070833,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)