P10412: Histone H1.4

General Information

Protein names	- Histone H1.4 - Histone H1b - Histone H1s-4
Gene names	HIST1H1E
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P10412

26 N-termini

10 C-termini

11 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MSETAPAAPA APAPAEKTPV KKKARKSAGA AKRKASGPPV SELITKAVAA SKERSGVSLA
        70         80         90        100        110        120
ALKKALAAAG YDVEKNNSRI KLGLKSLVSK GTLVQTKGTG ASGSFKLNKK AASGEAKPKA
       130        140        150        160        170        180
KKAGAAKAKK PAGAAKKPKK ATGAATPKKS AKKTPKKAKK PAAAAGAKKA KSPKKAKAAK
       190        200        210
PKKAPKSPAK AKAVKPKAAK PKTAKPKAAK PKKAAAKKK

Isoforms

Sequence View

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Physiological Relevance:

Evidence Codes:

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Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

26 N-termini - 10 C-termini - 11 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P10412-2-unknown	MSETAP...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P10412-2-unknown	MSETAP...	1			unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P10412-2-Acetylation	SETAPA...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P10412-2-Acetylation	SETAPA...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
P10412-2-Acetylation	SETAPA...	2	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
P10412-2-Acetylation	SETAPA...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
P10412-2-	SETAPA...	2			Subtiligase Based Positive Selection		Wells	DB_Untreated	23264352
P10412-2-	SETAPA...	2			Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
P10412-2-	SETAPA...	2			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P10412-2-	SETAPA...	2			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
P10412-2-	SETAPA...	2			Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
P10412-2-	SETAPA...	2			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P10412-2-	SETAPA...	2			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P10412-2-	SETAPA...	2			Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
P10412-2-	SETAPA...	2			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P10412-2-	SETAPA...	2			Subtiligase Based Positive Selection		Wells	apoptotic_RPMI_Dox	23264352
P10412-2-	SETAPA...	2			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P10412-4-	TAPAAP...	4			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P10412-4-	TAPAAP...	4			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P10412-7-	AAPAAP...	7			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P10412-7-	AAPAAP...	7			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P10412-7-	AAPAAP...	7			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P10412-11-unknown	APAPAE...	11		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17268
P10412-11-unknown	APAPAE...	11		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18649
P10412-22-unknown	KKARKS...	22		inferred from electronic annotation	unknown	TISdb		inferred from TISdb
P10412-34-unknown	KASGPP...	34		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13958
P10412-34-	KASGPP...	34			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P10412-34-	KASGPP...	34			Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
P10412-34-	KASGPP...	34			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P10412-34-	KASGPP...	34			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P10412-34-	KASGPP...	34			Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
P10412-34-	KASGPP...	34			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P10412-36-	SGPPVS...	36			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P10412-44-unknown	ITKAVA...	44		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13959
P10412-45-unknown	TKAVAA...	45		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13960
P10412-64-	KALAAA...	64			Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
P10412-65-unknown	ALAAAG...	65		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13961
P10412-65-	ALAAAG...	65			Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
P10412-65-	ALAAAG...	65			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P10412-65-	ALAAAG...	65			Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
P10412-65-	ALAAAG...	65			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P10412-65-	ALAAAG...	65			Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
P10412-65-	ALAAAG...	65			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P10412-65-	ALAAAG...	65			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P10412-67-unknown	AAAGYD...	67		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13962
P10412-68-unknown	AAGYDV...	68		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13963
P10412-68-unknown	AAGYDV...	68		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC9971
P10412-69-unknown	AGYDVE...	69		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13964
P10412-71-unknown	YDVEKN...	71		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13965
P10412-86-	SLVSKG...	86			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P10412-91-	GTLVQT...	91			Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
P10412-98-	GTGASG...	98			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P10412-98-	GTGASG...	98			Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
P10412-104-	SFKLNK...	104			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P10412-110-	KAASGE...	110			Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
P10412-140-	KATGAA...	140			Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
P10412-193-	AVKPKA...	193			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...PAAPAA	10	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17268
...PAAPAA	10	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18649
...GAAKRK	33	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13958
...PVSELI	43	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13959
...VSELIT	44	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13960
...AALKKA	64	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13961
...LKKALA	66	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13962
...KKALAA	67	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13963
...KKALAA	67	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9971
...KALAAA	68	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13964
...LAAAGY	70	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13965
...AAKKK	219	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MEP1A_HUMAN	10	APAA.\|.APAP	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	10	APAA.\|.APAP	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
GRAM_HUMAN	33	AKRK.\|.KASG	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
GRAM_HUMAN	43	SELI.\|.ITKA	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
GRAM_HUMAN	44	ELIT.\|.TKAV	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
GRAM_HUMAN	64	LKKA.\|.ALAA	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
GRAM_HUMAN	66	KALA.\|.AAAG	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
GRAM_HUMAN	67	ALAA.\|.AAGY	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
GRAA_HUMAN	67	ALAA.\|.AAGY	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:The substrate specificity profi... (S01.135)	20536382,
GRAM_HUMAN	68	LAAA.\|.AGYD	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
GRAM_HUMAN	70	AAGY.\|.YDVE	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)