P01034: Cystatin-C

General Information

Protein names	- Cystatin-C - Cystatin-3 - Gamma-trace - Neuroendocrine basic polypeptide - Post-gamma-globulin
Gene names	CST3
Organism	Homo sapiens
Protease Family
Protease ID	I25.004
Chromosome location
UniProt ID	P01034

13 N-termini

11 C-termini

16 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MAGPLRAPLL LLAILAVALA VSPAAGSSPG KPPRLVGGPM DASVEEEGVR RALDFAVGEY
        70         80         90        100        110        120
NKASNDMYHS RALQVVRARK QIVAGVNYFL DVELGRTTCT KTQPNLDNCP FHDQPHLKRK
       130        140
AFCSFQIYAV PWQGTMTLSK STCQDA

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

13 N-termini - 11 C-termini - 16 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name	Publications (PMID)
P01034-21-unknown	VSPAAG...	21		unknown		Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P01034-24-unknown	AAGSSP...	24		unknown		Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P01034-27-unknown	SSPGKP...	27	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P01034-27-unknown	SSPGKP...	27		unknown		Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P01034-35-unknown	LVGGPM...	35	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC22090
P01034-35-unknown	LVGGPM...	35	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16988
P01034-35-unknown	LVGGPM...	35	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18348
P01034-35-unknown	LVGGPM...	35		unknown		Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P01034-36-unknown	VGGPMD...	36	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16989
P01034-37-unknown	GGPMDA...	37	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8640
P01034-38-unknown	GPMDAS...	38	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16990
P01034-38-unknown	GPMDAS...	38	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18349
P01034-38-unknown	GPMDAS...	38	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5347
P01034-41-unknown	DASVEE...	41	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16991
P01034-41-unknown	DASVEE...	41	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18350
P01034-42-unknown	ASVEEE...	42	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16992
P01034-42-unknown	ASVEEE...	42	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18351
P01034-56-unknown	AVGEYN...	56	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4325
P01034-91-unknown	DVELGR...	91	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4326
P01034-129-unknown	AVPWQG...	129	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4327
P01034-139-unknown	SKSTCQ...	139	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4328

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...GKPPRL	34	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC22090
...GKPPRL	34	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16988
...GKPPRL	34	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18348
...KPPRLV	35	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16989
...PPRLVG	36	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8640
...PRLVGG	37	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16990
...PRLVGG	37	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18349
...PRLVGG	37	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5347
...VGGPMD	40	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16991
...VGGPMD	40	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18350
...GGPMDA	41	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16992
...GGPMDA	41	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18351
...RALDFA	55	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4325
...VNYFLD	90	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4326
...SFQIYA	128	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4327
...GTMTLS	138	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4328
...TCQDA	146	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MMP2_HUMAN	34	PPRL.\|.LVGG	inferred from experiment	unknown	MEROPS	Overall CM	Dean RA et al.:Identification of candidate ang... (M10.003)	17908800,
MEP1A_HUMAN	34	PPRL.\|.LVGG	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	34	PPRL.\|.LVGG	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	35	PRLV.\|.VGGP	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
ELNE_HUMAN	36	RLVG.\|.GGPM	inferred from experiment	unknown	MEROPS	Hall A	Abrahamson M et al.:Modification of cystatin C acti... (S01.131)	9536278,
MEP1A_HUMAN	37	LVGG.\|.GPMD	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	37	LVGG.\|.GPMD	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
CATL1_HUMAN	37	LVGG.\|.GPMD	inferred from experiment	unknown	MEROPS	Brzin J	Popovic T et al.:Cathepsin L is capable of trunc... (C01.032)	10428479,
MEP1A_HUMAN	40	GPMD.\|.DASV	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	40	GPMD.\|.DASV	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	41	PMDA.\|.ASVE	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	41	PMDA.\|.ASVE	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
CATD_HUMAN	55	LDFA.\|.AVGE	inferred from experiment	unknown	MEROPS	Turk V	Lenarcic B et al.:Inactivation of human cystatin ... (A01.009)	2013314,
CATD_HUMAN	90	YFLD.\|.DVEL	inferred from experiment	unknown	MEROPS	Turk V	Lenarcic B et al.:Inactivation of human cystatin ... (A01.009)	2013314,
CATD_HUMAN	128	QIYA.\|.AVPW	inferred from experiment	unknown	MEROPS	Turk V	Lenarcic B et al.:Inactivation of human cystatin ... (A01.009)	2013314,
CATD_HUMAN	138	MTLS.\|.SKST	inferred from experiment	unknown	MEROPS	Turk V	Lenarcic B et al.:Inactivation of human cystatin ... (A01.009)	2013314,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)