Q02750: Dual specificity mitogen-activated protein kinase kinase 1

General Information

Protein names	- Dual specificity mitogen-activated protein kinase kinase 1 - MAP kinase kinase 1 - MAPKK 1 - MKK1 - 2.7.12.2 - ERK activator kinase 1 - MAPK/ERK kinase 1 - MEK 1
Gene names	MAP2K1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q02750

10 N-termini

4 C-termini

3 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MPKKKPTPIQ LNPAPDGSAV NGTSSAETNL EALQKKLEEL ELDEQQRKRL EAFLTQKQKV
        70         80         90        100        110        120
GELKDDDFEK ISELGAGNGG VVFKVSHKPS GLVMARKLIH LEIKPAIRNQ IIRELQVLHE
       130        140        150        160        170        180
CNSPYIVGFY GAFYSDGEIS ICMEHMDGGS LDQVLKKAGR IPEQILGKVS IAVIKGLTYL
       190        200        210        220        230        240
REKHKIMHRD VKPSNILVNS RGEIKLCDFG VSGQLIDSMA NSFVGTRSYM SPERLQGTHY
       250        260        270        280        290        300
SVQSDIWSMG LSLVEMAVGR YPIPPPDAKE LELMFGCQVE GDAAETPPRP RTPGRPLSSY
       310        320        330        340        350        360
GMDSRPPMAI FELLDYIVNE PPPKLPSGVF SLEFQDFVNK CLIKNPAERA DLKQLMVHAF
       370        380        390
IKRSDAEEVD FAGWLCSTIG LNQPSTPTHA AGV

Isoforms

- Isoform 2 of Dual specificity mitogen-activated protein kinase kinase 1

Sequence View

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Protein Neighborhood

Domains & Features

10 N-termini - 4 C-termini - 3 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q02750-1-unknown	MPKKKP...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt81424
Q02750-1-unknown	MPKKKP...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q02750-2-unknown	PKKKPT...	2	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q02750-2-unknown	PKKKPT...	2	inferred from similarity	unknown	UniProtKB		inferred from uniprot (by similarity)
Q02750-2-unknown	PKKKPT...	2	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt111541
Q02750-17-unknown	GSAVNG...	17		unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q02750-17-unknown	GSAVNG...	17	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt161827
Q02750-17-	GSAVNG...	17		Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
Q02750-17-	GSAVNG...	17		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
Q02750-17-	GSAVNG...	17		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q02750-17-	GSAVNG...	17		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q02750-17-	GSAVNG...	17		Subtiligase Based Positive Selection		Wells	apoptotic_RPMI_Dox	23264352
Q02750-17-	GSAVNG...	17		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q02750-22-unknown	GTSSAE...	22	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19317
Q02750-22-unknown	GTSSAE...	22		unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q02750-22-unknown	GTSSAE...	22	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt136998
Q02750-22-	GTSSAE...	22		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
Q02750-22-	GTSSAE...	22		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q02750-22-	GTSSAE...	22		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q02750-26-unknown	AETNLE...	26	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19319
Q02750-26-unknown	AETNLE...	26	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt137269
Q02750-283-unknown	AAETPP...	283		unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q02750-283-unknown	AAETPP...	283	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt161825
Q02750-283-	AAETPP...	283		Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
Q02750-283-	AAETPP...	283		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q02750-283-	AAETPP...	283		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
Q02750-283-	AAETPP...	283		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q02750-283-	AAETPP...	283		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q02750-283-	AAETPP...	283		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q02750-381-unknown	LNQPST...	381	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3952
Q02750-381-unknown	LNQPST...	381	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt151054

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...GSAVNG	21	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19317
...GSAVNG	21	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt119840
...NGTSSA	25	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19319
...NGTSSA	25	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt120201
...CSTIGL	380	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3952
...CSTIGL	380	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt134457
...HAAGV	393	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...HAAGV	393	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt77042

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MEP1B_HUMAN	21	AVNG.\|.GTSS	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	25	TSSA.\|.AETN	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
CATB_HUMAN	380	TIGL.\|.LNQP	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)