Q14956: Transmembrane glycoprotein NMB

General Information

Protein names	- Transmembrane glycoprotein NMB - Hematopoietic growth factor inducible neurokinin-1 type {ECO:0000303\|PubMed:12609765}
Gene names	GPNMB
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q14956

3 N-termini

2 C-termini

2 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MECLYYFLGF LLLAARLPLD AAKRFHDVLG NERPSAYMRE HNQLNGWSSD ENDWNEKLYP
        70         80         90        100        110        120
VWKRGDMRWK NSWKGGRVQA VLTSDSPALV GSNITFAVNL IFPRCQKEDA NGNIVYEKNC
       130        140        150        160        170        180
RNEAGLSADP YVYNWTAWSE DSDGENGTGQ SHHNVFPDGK PFPHHPGWRR WNFIYVFHTL
       190        200        210        220        230        240
GQYFQKLGRC SVRVSVNTAN VTLGPQLMEV TVYRRHGRAY VPIAQVKDVY VVTDQIPVFV
       250        260        270        280        290        300
TMFQKNDRNS SDETFLKDLP IMFDVLIHDP SHFLNYSTIN YKWSFGDNTG LFVSTNHTVN
       310        320        330        340        350        360
HTYVLNGTFS LNLTVKAAAP GPCPPPPPPP RPSKPTPSLA TTLKSYDSNT PGPAGDNPLE
       370        380        390        400        410        420
LSRIPDENCQ INRYGHFQAT ITIVEGILEV NIIQMTDVLM PVPWPESSLI DFVVTCQGSI
       430        440        450        460        470        480
PTEVCTIISD PTCEITQNTV CSPVDVDEMC LLTVRRTFNG SGTYCVNLTL GDDTSLALTS
       490        500        510        520        530        540
TLISVPDRDP ASPLRMANSA LISVGCLAIF VTVISLLVYK KHKEYNPIEN SPGNVVRSKG
       550        560        570
LSVFLNRAKA VFFPGNQEKD PLLKNQEFKG VS

Isoforms

- Isoform 2 of Transmembrane glycoprotein NMB

Sequence View

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Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

3 N-termini - 2 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
Q14956-1-unknown	MECLYY...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt76320
Q14956-22-unknown	AKRFHD...	22	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q14956-22-unknown	AKRFHD...	22	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt113051
Q14956-155-unknown	VFPDGK...	155	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17947
Q14956-155-unknown	VFPDGK...	155	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19532
Q14956-155-unknown	VFPDGK...	155	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt144932

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...QSHHNV	154	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17947
...QSHHNV	154	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19532
...QSHHNV	154	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt128208
...FKGVS	572	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...FKGVS	572	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt71938

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MEP1A_HUMAN	154	HHNV.\|.VFPD	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	154	HHNV.\|.VFPD	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)