P22033: Methylmalonyl-CoA mutase, mitochondrial {ECO:0000305}

General Information

Protein names	- Methylmalonyl-CoA mutase, mitochondrial {ECO:0000305} - MCM - 5.4.99.2 {ECO:0000269\|PubMed:25125334, ECO:0000269\|PubMed:28101778} - Methylmalonyl-CoA isomerase
Gene names	MUT
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P22033

4 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MLRAKNQLFL LSPHYLRQVK ESSGSRLIQQ RLLHQQQPLH PEWAALAKKQ LKGKNPEDLI
        70         80         90        100        110        120
WHTPEGISIK PLYSKRDTMD LPEELPGVKP FTRGPYPTMY TFRPWTIRQY AGFSTVEESN
       130        140        150        160        170        180
KFYKDNIKAG QQGLSVAFDL ATHRGYDSDN PRVRGDVGMA GVAIDTVEDT KILFDGIPLE
       190        200        210        220        230        240
KMSVSMTMNG AVIPVLANFI VTGEEQGVPK EKLTGTIQND ILKEFMVRNT YIFPPEPSMK
       250        260        270        280        290        300
IIADIFEYTA KHMPKFNSIS ISGYHMQEAG ADAILELAYT LADGLEYSRT GLQAGLTIDE
       310        320        330        340        350        360
FAPRLSFFWG IGMNFYMEIA KMRAGRRLWA HLIEKMFQPK NSKSLLLRAH CQTSGWSLTE
       370        380        390        400        410        420
QDPYNNIVRT AIEAMAAVFG GTQSLHTNSF DEALGLPTVK SARIARNTQI IIQEESGIPK
       430        440        450        460        470        480
VADPWGGSYM MECLTNDVYD AALKLINEIE EMGGMAKAVA EGIPKLRIEE CAARRQARID
       490        500        510        520        530        540
SGSEVIVGVN KYQLEKEDAV EVLAIDNTSV RNRQIEKLKK IKSSRDQALA ERCLAALTEC
       550        560        570        580        590        600
AASGDGNILA LAVDASRARC TVGEITDALK KVFGEHKAND RMVSGAYRQE FGESKEITSA
       610        620        630        640        650        660
IKRVHKFMER EGRRPRLLVA KMGQDGHDRG AKVIATGFAD LGFDVDIGPL FQTPREVAQQ
       670        680        690        700        710        720
AVDADVHAVG ISTLAAGHKT LVPELIKELN SLGRPDILVM CGGVIPPQDY EFLFEVGVSN
       730        740        750
VFGPGTRIPK AAVQVLDDIE KCLEKKQQSV

Isoforms

Sequence View

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Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

4 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P22033-33-	LHQQQP...	33		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P22033-33-	LHQQQP...	33		Subtiligase Based Positive Selection		Wells	apopotic_Jurkat_FasL	23264352
P22033-33-	LHQQQP...	33		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P22033-33-	LHQQQP...	33		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P22033-33-	LHQQQP...	33		Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
P22033-33-	LHQQQP...	33		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P22033-33-unknown	LHQQQP...	33	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P22033-37-unknown	QPLHPE...	37	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18901
P22033-389-	SFDEAL...	389		Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352

C-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
	...LLHQQQ	36	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18901
	...KQQSV	750	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MEP1B_HUMAN	36	HQQQ.\|.QPLH	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)