Q9H2U2: Inorganic pyrophosphatase 2, mitochondrial

General Information

Protein names	- Inorganic pyrophosphatase 2, mitochondrial - 3.6.1.1 - Pyrophosphatase SID6-306 - Pyrophosphate phospho-hydrolase 2 - PPase 2
Gene names	PPA2
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9H2U2

11 N-termini

7 C-termini

2 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Inorganic pyrophosphatase 2, mitochondrial - Isoform 3 of Inorganic pyrophosphatase 2, mitochondrial - Isoform 4 of Inorganic pyrophosphatase 2, mitochondrial - Isoform 5 of Inorganic pyrophosphatase 2, mitochondrial

Sequence View

        10         20         30         40         50         60
MSALLRLLRT GAPAAACLRL GTSAGTGSRR AMALYHTEER GQPCSQNYRL FFKNVTGHYI
        70         80         90        100        110        120
SPFHDIPLKV NSKEENGIPM KKARNDEYEN LFNMIVEIPR WTNAKMEIAT KEPMNPIKQY
       130        140        150        160        170        180
VKDGKLRYVA NIFPYKGYIW NYGTLPQTWE DPHEKDKSTN CFGDNDPIDV CEIGSKILSC
       190        200        210        220        230        240
GEVIHVKILG ILALIDEGET DWKLIAINAN DPEASKFHDI DDVKKFKPGY LEATLNWFRL
       250        260        270        280        290        300
YKVPDGKPEN QFAFNGEFKN KAFALEVIKS THQCWKALLM KKCNGGAINC TNVQISDSPF
       310        320        330
RCTQEEARSL VESVSSSPNK ESNEEEQVWH FLGK         10         20         30         40         50         60
MSALLRLLRT GAPAAACLRL GTSAGTGSRR AMALYHTEER GQPCSQNYRL FFKNVTGHYI
        70         80         90        100        110        120
SPFHDIPLKV NSKEENGIPM KKARNDEYEN LFNMIVEIPR WTNAKMEIAT KEPMNPIKQY
       130        140        150        160        170        180
VKDGKLRYVA NIFPYKGYIW NYGTLPQTWE DPHEKDKSTN CFGDNDPIDV CEIGSKILSC
       190        200        210        220        230        240
GEVIHVKILG ILALIDEGET DWKLIAINAN DPEASKFHDI DDVKKFKPGY LEATLNWFRL
       250        260        270        280        290        300
YKVPDGKPEN QFAFNGEFKN KAFALEVIKS THQCWKALLM KKCNGGAINC TNVQISDSPF
       310        320        330
RCTQEEARSL VESVSSSPNK ESNEEEQVWH FLGK         10         20         30         40         50         60
MSALLRLLRT GAPAAACLRL GTSAGTGSRR AMALYHTEER GQPCSQNYRL FFKNVTGHYI
        70         80         90        100        110        120
SPFHDIPLKV NSKEENGIPM KKARNDEYEN LFNMIVEIPR WTNAKMEIAT KEPMNPIKQY
       130        140        150        160        170        180
VKDGKLRYVA NIFPYKGYIW NYGTLPQTWE DPHEKDKSTN CFGDNDPIDV CEIGSKILSC
       190        200        210        220        230        240
GEVIHVKILG ILALIDEGET DWKLIAINAN DPEASKFHDI DDVKKFKPGY LEATLNWFRL
       250        260        270        280        290        300
YKVPDGKPEN QFAFNGEFKN KAFALEVIKS THQCWKALLM KKCNGGAINC TNVQISDSPF
       310        320        330
RCTQEEARSL VESVSSSPNK ESNEEEQVWH FLGK         10         20         30         40         50         60
MSALLRLLRT GAPAAACLRL GTSAGTGSRR AMALYHTEER GQPCSQNYRL FFKNVTGHYI
        70         80         90        100        110        120
SPFHDIPLKV NSKEENGIPM KKARNDEYEN LFNMIVEIPR WTNAKMEIAT KEPMNPIKQY
       130        140        150        160        170        180
VKDGKLRYVA NIFPYKGYIW NYGTLPQTWE DPHEKDKSTN CFGDNDPIDV CEIGSKILSC
       190        200        210        220        230        240
GEVIHVKILG ILALIDEGET DWKLIAINAN DPEASKFHDI DDVKKFKPGY LEATLNWFRL
       250        260        270        280        290        300
YKVPDGKPEN QFAFNGEFKN KAFALEVIKS THQCWKALLM KKCNGGAINC TNVQISDSPF
       310        320        330
RCTQEEARSL VESVSSSPNK ESNEEEQVWH FLGK

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

11 N-termini - 7 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q9H2U2-1-unknown	MSALLR...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt78019
Q9H2U2-1-unknown	MSALLR...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt78020
Q9H2U2-1-unknown	MSALLR...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt78021
Q9H2U2-1-unknown	MSALLR...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt78022
Q9H2U2-32-	MALYHT...	32			Subtiligase Based Positive Selection		Wells	DB_Untreated	23264352
Q9H2U2-32-	MALYHT...	32			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q9H2U2-32-	MALYHT...	32			Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
Q9H2U2-32-	MALYHT...	32			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q9H2U2-32-	MALYHT...	32			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q9H2U2-32-	MALYHT...	32			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q9H2U2-32-unknown	MALYHT...	32		inferred from electronic annotation	unknown	TISdb		inferred from TISdb
Q9H2U2-32-unknown	MALYHT...	32		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt164878
Q9H2U2-32-unknown	MALYHT...	32		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt164879
Q9H2U2-32-unknown	MALYHT...	32		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt164880
Q9H2U2-32-unknown	MALYHT...	32		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt164881
Q9H2U2-33-unknown	ALYHTE...	33		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9H2U2-33-unknown	ALYHTE...	33			unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q9H2U2-33-unknown	ALYHTE...	33		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt115030
Q9H2U2-33-unknown	ALYHTE...	33		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt115031
Q9H2U2-33-unknown	ALYHTE...	33		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt115032
Q9H2U2-33-	ALYHTE...	33			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
Q9H2U2-33-	ALYHTE...	33			Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
Q9H2U2-33-	ALYHTE...	33			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q9H2U2-33-	ALYHTE...	33			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q9H2U2-33-acetylation	ALYHTE...	33	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
Q9H2U2-33-acetylation	ALYHTE...	33	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt183227
Q9H2U2-33-acetylation	ALYHTE...	33	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt183228
Q9H2U2-33-acetylation	ALYHTE...	33	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt183229
Q9H2U2-80-unknown	MKKARN...	80		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000426347
Q9H2U2-80-unknown	MKKARN...	80		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000311150
Q9H2U2-80-unknown	MKKARN...	80		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt196635
Q9H2U2-80-unknown	MKKARN...	80		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt196636
Q9H2U2-180-unknown	CGEVIH...	180		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC8087
Q9H2U2-180-unknown	CGEVIH...	180		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt146435
Q9H2U2-180-unknown	CGEVIH...	180		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt197895
Q9H2U2-180-unknown	CGEVIH...	180		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt197896
Q9H2U2-227-	KPGYLE...	227			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q9H2U2-227-unknown	KPGYLE...	227		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt175283
Q9H2U2-227-unknown	KPGYLE...	227		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt175282
Q9H2U2-227-unknown	KPGYLE...	227		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt175284
Q9H2U2-227-unknown	KPGYLE...	227		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt175285
Q9H2U2-326-unknown	EQVWHF...	326		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19791
Q9H2U2-326-unknown	EQVWHF...	326		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt145131
Q9H2U2-326-unknown	EQVWHF...	326		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt147516
Q9H2U2-326-unknown	EQVWHF...	326		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt149789
Q9H2U2-326-unknown	EQVWHF...	326		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt150755

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...GDNDPI	167	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000426347
...GDNDPI	167	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt155225
...SKILSC	179	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8087
...SKILSC	179	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt129740
...DEGETD	200	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000421177
...DEGETD	200	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt155632
...DEGETD	200	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt155633
...DEGETD	200	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt155634
...VPDGKP	247	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000423889
...NKAFAL	264	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000423363
...ESNEEE	325	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19791
...ESNEEE	325	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt128417
...ESNEEE	325	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt130866
...ESNEEE	325	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt133180
...ESNEEE	325	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt134155
...HFLGK	334	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...HFLGK	334	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt73639
...HFLGK	334	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt73640
...HFLGK	334	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt73638
...HFLGK	334	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt73637

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATS_HUMAN	179	ILSC.\|.CGEV	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
MEP1B_HUMAN	325	NEEE.\|.EQVW	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)