Q96CT7: Coiled-coil domain-containing protein 124

General Information

Protein names	- Coiled-coil domain-containing protein 124
Gene names	CCDC124
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q96CT7

8 N-termini

4 C-termini

2 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MPKKFQGENT KSAAARARRA EAKAAADAKK QKELEDAYWK DDDKHVMRKE QRKEEKEKRR
        70         80         90        100        110        120
LDQLERKKET QRLLEEEDSK LKGGKAPRVA TSSKVTRAQI EDTLRRDHQL REAPDTAEKA
       130        140        150        160        170        180
KSHLEVPLEE NVNRRVLEEG SVEARTIEDA IAVLSVAEEA ADRHPERRMR AAFTAFEEAQ
       190        200        210        220
LPRLKQENPN MRLSQLKQLL KKEWLRSPDN PMNQRAVPFN APK

Isoforms

Sequence View

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Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

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Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

8 N-termini - 4 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q96CT7-1-unknown	MPKKFQ...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q96CT7-2-unknown	PKKFQG...	2		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
Q96CT7-2-unknown	PKKFQG...	2		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q96CT7-36-unknown	DAYWKD...	36	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19736
Q96CT7-36-unknown	DAYWKD...	36	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18074
Q96CT7-122-	SHLEVP...	122		Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
Q96CT7-122-	SHLEVP...	122		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
Q96CT7-122-	SHLEVP...	122		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q96CT7-122-unknown	SHLEVP...	122		unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q96CT7-150-	AIAVLS...	150		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q96CT7-150-	AIAVLS...	150		Subtiligase Based Positive Selection		Wells	apoptotic_RPMI_Dox	23264352
Q96CT7-155-	SVAEEA...	155		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
Q96CT7-155-	SVAEEA...	155		Subtiligase Based Positive Selection		Wells	apopotic_Jurkat_FasL	23264352
Q96CT7-155-	SVAEEA...	155		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
Q96CT7-155-unknown	SVAEEA...	155		unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q96CT7-155-unknown	SVAEEA...	155		unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...QKELED	35	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19736
...QKELED	35	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18074
...VNRRVL	136	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000472520
...FNAPK	223		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...FNAPK	223		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,
...FNAPK	223	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...FNAPK	223		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...FNAPK	223		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MEP1B_HUMAN	35	ELED.\|.DAYW	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	35	ELED.\|.DAYW	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)