P26038: Moesin {ECO:0000303|PubMed:1924289}

General Information

Protein names	- Moesin {ECO:0000303\|PubMed:1924289} - Membrane-organizing extension spike protein
Gene names	MSN
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P26038

7 N-termini

4 C-termini

2 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MPKTISVRVT TMDAELEFAI QPNTTGKQLF DQVVKTIGLR EVWFFGLQYQ DTKGFSTWLK
        70         80         90        100        110        120
LNKKVTAQDV RKESPLLFKF RAKFYPEDVS EELIQDITQR LFFLQVKEGI LNDDIYCPPE
       130        140        150        160        170        180
TAVLLASYAV QSKYGDFNKE VHKSGYLAGD KLLPQRVLEQ HKLNKDQWEE RIQVWHEEHR
       190        200        210        220        230        240
GMLREDAVLE YLKIAQDLEM YGVNYFSIKN KKGSELWLGV DALGLNIYEQ NDRLTPKIGF
       250        260        270        280        290        300
PWSEIRNISF NDKKFVIKPI DKKAPDFVFY APRLRINKRI LALCMGNHEL YMRRRKPDTI
       310        320        330        340        350        360
EVQQMKAQAR EEKHQKQMER AMLENEKKKR EMAEKEKEKI EREKEELMER LKQIEEQTKK
       370        380        390        400        410        420
AQQELEEQTR RALELEQERK RAQSEAEKLA KERQEAEEAK EALLQASRDQ KKTQEQLALE
       430        440        450        460        470        480
MAELTARISQ LEMARQKKES EAVEWQQKAQ MVQEDLEKTR AELKTAMSTP HVAEPAENEQ
       490        500        510        520        530        540
DEQDENGAEA SADLRADAMA KDRSEEERTT EAEKNERVQK HLKALTSELA NARDESKKTA
       550        560        570
NDMIHAENMR LGRDKYKTLR QIRQGNTKQR IDEFESM

Isoforms

Sequence View

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

7 N-termini - 4 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P26038-1-unknown	MPKTIS...	1		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
P26038-2-unknown	PKTISV...	2	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P26038-2-unknown	PKTISV...	2		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
P26038-2-unknown	PKTISV...	2		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
P26038-12-unknown	MDAELE...	12	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000477441
P26038-396-unknown	AEEAKE...	396	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18977
P26038-396-unknown	AEEAKE...	396	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17534
P26038-451-	MVQEDL...	451		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P26038-468-	STPHVA...	468		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P26038-468-	STPHVA...	468		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P26038-487-	GAEASA...	487		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...ILNDDI	114	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000477441
...KERQEA	395	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18977
...KERQEA	395	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17534
...EFESM	577		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...EFESM	577		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,
...EFESM	577	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...EFESM	577		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...EFESM	577		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MEP1B_HUMAN	395	RQEA.\|.AEEA	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	395	RQEA.\|.AEEA	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)