P21796: Voltage-dependent anion-selective channel protein 1

General Information

Protein names	- Voltage-dependent anion-selective channel protein 1 - VDAC-1 - hVDAC1 - Outer mitochondrial membrane protein porin 1 - Plasmalemmal porin - Porin 31HL - Porin 31HM
Gene names	VDAC1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P21796

5 N-termini

4 C-termini

3 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MAVPPTYADL GKSARDVFTK GYGFGLIKLD LKTKSENGLE FTSSGSANTE TTKVTGSLET
        70         80         90        100        110        120
KYRWTEYGLT FTEKWNTDNT LGTEITVEDQ LARGLKLTFD SSFSPNTGKK NAKIKTGYKR
       130        140        150        160        170        180
EHINLGCDMD FDIAGPSIRG ALVLGYEGWL AGYQMNFETA KSRVTQSNFA VGYKTDEFQL
       190        200        210        220        230        240
HTNVNDGTEF GGSIYQKVNK KLETAVNLAW TAGNSNTRFG IAAKYQIDPD ACFSAKVNNS
       250        260        270        280
SLIGLGYTQT LKPGIKLTLS ALLDGKNVNA GGHKLGLGLE FQA

Isoforms

Sequence View

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Physiological Relevance:

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Biological System:

Protease Assignment Confidence:

Evidence Names:

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Protein Neighborhood

Domains & Features

5 N-termini - 4 C-termini - 3 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P21796-2-unknown	MAVPPT...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P21796-2-unknown	MAVPPT...	1		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC16788
P21796-2-Acetylation	AVPPTY...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P21796-2-Acetylation	AVPPTY...	2	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
P21796-46-	SANTET...	46			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P21796-100-unknown	DSSFSP...	100		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18899
P21796-101-unknown	SSFSPN...	101		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18900

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...LKLTFD	99	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18899
...KLTFDS	100	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18900
...LHTNVN	184	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000390129
...LEFQA	283	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MAP12_HUMAN	1	.\|.AVPP	inferred from experiment	unknown	MEROPS		Merops MAP12_HUMAN -> VDAC1_HUMAN @1
MEP1B_HUMAN	99	LTFD.\|.DSSF	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	100	TFDS.\|.SSFS	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)