P60174: Triosephosphate isomerase {ECO:0000305|PubMed:18562316}

General Information

Protein names	- Triosephosphate isomerase {ECO:0000305\|PubMed:18562316} - TIM - 5.3.1.1 {ECO:0000269\|PubMed:18562316} - Methylglyoxal synthase {ECO:0000250\|UniProtKB:P00939} - 4.2.3.3 {ECO:0000250\|UniProtKB:P00939} - Triose-phosphate isomerase
Gene names	TPI1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P60174

21 N-termini

11 C-termini

11 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Triosephosphate isomerase - Isoform 4 of Triosephosphate isomerase

Sequence View

        10         20         30         40         50         60
MAEDGEEAEF HFAALYISGQ WPRLRADTDL QRLGSSAMAP SRKFFVGGNW KMNGRKQSLG
        70         80         90        100        110        120
ELIGTLNAAK VPADTEVVCA PPTAYIDFAR QKLDPKIAVA AQNCYKVTNG AFTGEISPGM
       130        140        150        160        170        180
IKDCGATWVV LGHSERRHVF GESDELIGQK VAHALAEGLG VIACIGEKLD EREAGITEKV
       190        200        210        220        230        240
VFEQTKVIAD NVKDWSKVVL AYEPVWAIGT GKTATPQQAQ EVHEKLRGWL KSNVSDAVAQ
       250        260        270        280
STRIIYGGSV TGATCKELAS QPDVDGFLVG GASLKPEFVD IINAKQ         10         20         30         40         50         60
MAEDGEEAEF HFAALYISGQ WPRLRADTDL QRLGSSAMAP SRKFFVGGNW KMNGRKQSLG
        70         80         90        100        110        120
ELIGTLNAAK VPADTEVVCA PPTAYIDFAR QKLDPKIAVA AQNCYKVTNG AFTGEISPGM
       130        140        150        160        170        180
IKDCGATWVV LGHSERRHVF GESDELIGQK VAHALAEGLG VIACIGEKLD EREAGITEKV
       190        200        210        220        230        240
VFEQTKVIAD NVKDWSKVVL AYEPVWAIGT GKTATPQQAQ EVHEKLRGWL KSNVSDAVAQ
       250        260        270        280
STRIIYGGSV TGATCKELAS QPDVDGFLVG GASLKPEFVD IINAKQ

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Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

21 N-termini - 11 C-termini - 11 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P60174-1-unknown	MAEDGE...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P60174-70-unknown	KVPADT...	70		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14225
P60174-110-	GAFTGE...	110			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P60174-110-	GAFTGE...	110			Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
P60174-112-unknown	FTGEIS...	112		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17755
P60174-113-unknown	TGEISP...	113		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17757
P60174-120-unknown	MIKDCG...	120		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt92850
P60174-142-unknown	ESDELI...	142		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7601
P60174-142-unknown	ESDELI...	142		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt137082
P60174-157-unknown	EGLGVI...	157		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19227
P60174-157-unknown	EGLGVI...	157		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt138160
P60174-183-unknown	EQTKVI...	183		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7604
P60174-183-unknown	EQTKVI...	183		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt140243
P60174-201-unknown	AYEPVW...	201		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt168685
P60174-201-	AYEPVW...	201			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
P60174-232-	SNVSDA...	232			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P60174-232-unknown	SNVSDA...	232		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt178194
P60174-232-unknown	SNVSDA...	232		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P60174-232-unknown	SNVSDA...	232		inferred from similarity	unknown	UniProtKB		inferred from uniprot (by similarity)
P60174-232-acetylation	SNVSDA...	232	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P60174-232-acetylation	SNVSDA...	232	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt182845
P60174-236-acetylation	DAVAQS...	236	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
P60174-236-acetylation	DAVAQS...	236	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt163304
P60174-248-unknown	GSVTGA...	248		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6065
P60174-248-unknown	GSVTGA...	248		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt143861
P60174-269-unknown	VGGASL...	269		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3874
P60174-269-unknown	VGGASL...	269		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt144714
P60174-271-unknown	GASLKP...	271		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3877
P60174-271-unknown	GASLKP...	271		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6068
P60174-271-unknown	GASLKP...	271		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt144805
P60174-273-	SLKPEF...	273			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P60174-273-	SLKPEF...	273			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P60174-273-unknown	SLKPEF...	273		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt175635
P60174-274-unknown	LKPEFV...	274		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17759
P60174-274-unknown	LKPEFV...	274		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt144947

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...TLNAAK	69	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14225
...VTNGAF	111	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17755
...TNGAFT	112	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17757
...RHVFGE	141	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7601
...RHVFGE	141	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt119944
...AHALAE	156	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19227
...AHALAE	156	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt121186
...EKVVFE	182	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7604
...EKVVFE	182	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt123362
...RIIYGG	247	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6065
...RIIYGG	247	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt127105
...VDGFLV	268	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3874
...VDGFLV	268	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt127982
...GFLVGG	270	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3877
...GFLVGG	270	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6068
...GFLVGG	270	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt128081
...VGGASL	273	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17759
...VGGASL	273	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt128223
...INAKQ	286	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...INAKQ	286	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt88468

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAM_HUMAN	69	NAAK.\|.KVPA	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
MEP1A_HUMAN	111	NGAF.\|.FTGE	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	112	GAFT.\|.TGEI	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
CATS_HUMAN	141	VFGE.\|.ESDE	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
MEP1B_HUMAN	156	ALAE.\|.EGLG	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
CATS_HUMAN	182	VVFE.\|.EQTK	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	247	IYGG.\|.GSVT	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATB_HUMAN	268	GFLV.\|.VGGA	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATB_HUMAN	270	LVGG.\|.GASL	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	270	LVGG.\|.GASL	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
MEP1A_HUMAN	273	GASL.\|.LKPE	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)