P52566: Rho GDP-dissociation inhibitor 2

General Information

Protein names	- Rho GDP-dissociation inhibitor 2 - Rho GDI 2 - Ly-GDI {ECO:0000303\|PubMed:8356058} - Rho-GDI beta
Gene names	ARHGDIB
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P52566

17 N-termini

6 C-termini

3 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MTEKAPEPHV EEDDDDELDS KLNYKPPPQK SLKELQEMDK DDESLIKYKK TLLGDGPVVT
        70         80         90        100        110        120
DPKAPNVVVT RLTLVCESAP GPITMDLTGD LEALKKETIV LKEGSEYRVK IHFKVNRDIV
       130        140        150        160        170        180
SGLKYVQHTY RTGVKVDKAT FMVGSYGPRP EEYEFLTPVE EAPKGMLARG TYHNKSFFTD
       190        200
DDKQDHLSWE WNLSIKKEWT E

Isoforms

Sequence View

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Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

17 N-termini - 6 C-termini - 3 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P52566-2-unknown	MTEKAP...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P52566-2-Acetylation	TEKAPE...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P52566-20-	SKLNYK...	20			Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
P52566-20-	SKLNYK...	20			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P52566-20-	SKLNYK...	20			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P52566-20-	SKLNYK...	20			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P52566-20-	SKLNYK...	20			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P52566-20-unknown	SKLNYK...	20		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1901
P52566-20-unknown	SKLNYK...	20			unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P52566-22-unknown	LNYKPP...	22			unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P52566-22-	LNYKPP...	22			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P52566-31-	SLKELQ...	31			Subtiligase Based Positive Selection		Wells	DB_Untreated	23264352
P52566-31-	SLKELQ...	31			Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
P52566-31-	SLKELQ...	31			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
P52566-31-	SLKELQ...	31			Subtiligase Based Positive Selection		Wells	apopotic_Jurkat_FasL	23264352
P52566-31-	SLKELQ...	31			Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
P52566-31-	SLKELQ...	31			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P52566-31-	SLKELQ...	31			Subtiligase Based Positive Selection		Wells	apoptotic_RPMI_Dox	23264352
P52566-31-unknown	SLKELQ...	31			unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P52566-48-	YKKTLL...	48			Subtiligase Based Positive Selection		Wells	apopotic_Jurkat_FasL	23264352
P52566-50-	KTLLGD...	50			Subtiligase Based Positive Selection		Wells	DB_Untreated	23264352
P52566-50-	KTLLGD...	50			Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
P52566-50-	KTLLGD...	50			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
P52566-50-	KTLLGD...	50			Subtiligase Based Positive Selection		Wells	apopotic_Jurkat_FasL	23264352
P52566-50-	KTLLGD...	50			Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
P52566-50-	KTLLGD...	50			Subtiligase Based Positive Selection		Wells	apoptotic_RPMI_Dox	23264352
P52566-50-unknown	KTLLGD...	50			unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P52566-50-unknown	KTLLGD...	50			unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P52566-51-	TLLGDG...	51			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P52566-51-	TLLGDG...	51			Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
P52566-51-	TLLGDG...	51			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P52566-55-unknown	DGPVVT...	55		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17715
P52566-55-unknown	DGPVVT...	55		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19187
P52566-56-	GPVVTD...	56			Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
P52566-78-	SAPGPI...	78			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P52566-78-	SAPGPI...	78			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P52566-142-	MVGSYG...	142			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P52566-145-	SYGPRP...	145			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P52566-145-	SYGPRP...	145			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P52566-145-	SYGPRP...	145			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P52566-145-	SYGPRP...	145			Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
P52566-145-	SYGPRP...	145			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P52566-145-	SYGPRP...	145			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...DDELDS	19	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1901
...KTLLGD	54	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17715
...KTLLGD	54	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19187
...TMDLTG	88	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000445450
...RVKIHF	112	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000437454
...EFLTPV	158	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000445263
...KEWTE	201	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CASP3_HUMAN	19	ELDS.\|.SKLN	inferred from experiment	unknown	MEROPS	Bokoch GM	Danley DE et al.:Defective Rho GTPase regulation... (C14.003)	8752894,
MEP1A_HUMAN	54	LLGD.\|.DGPV	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	54	LLGD.\|.DGPV	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)