P10809: 60 kDa heat shock protein, mitochondrial
Protein names | - 60 kDa heat shock protein, mitochondrial - 5.6.1.7 {ECO:0000305} - 60 kDa chaperonin - Chaperonin 60 - CPN60 - Heat shock protein 60 - HSP-60 - Hsp60 - HuCHA60 - Mitochondrial matrix protein P1 - P60 lymphocyte protein |
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Gene names | HSPD1 |
Organism | Homo sapiens |
Protease Family | |
Protease ID | |
Chromosome location | |
UniProt ID | P10809 |
50
N-termini
30
C-termini
33
Cleavages
0
Substrates
Sequence
10 20 30 40 50 60
MLRLPTVFRQ MRPVSRVLAP HLTRAYAKDV KFGADARALM LQGVDLLADA VAVTMGPKGR
70 80 90 100 110 120
TVIIEQSWGS PKVTKDGVTV AKSIDLKDKY KNIGAKLVQD VANNTNEEAG DGTTTATVLA
130 140 150 160 170 180
RSIAKEGFEK ISKGANPVEI RRGVMLAVDA VIAELKKQSK PVTTPEEIAQ VATISANGDK
190 200 210 220 230 240
EIGNIISDAM KKVGRKGVIT VKDGKTLNDE LEIIEGMKFD RGYISPYFIN TSKGQKCEFQ
250 260 270 280 290 300
DAYVLLSEKK ISSIQSIVPA LEIANAHRKP LVIIAEDVDG EALSTLVLNR LKVGLQVVAV
310 320 330 340 350 360
KAPGFGDNRK NQLKDMAIAT GGAVFGEEGL TLNLEDVQPH DLGKVGEVIV TKDDAMLLKG
370 380 390 400 410 420
KGDKAQIEKR IQEIIEQLDV TTSEYEKEKL NERLAKLSDG VAVLKVGGTS DVEVNEKKDR
430 440 450 460 470 480
VTDALNATRA AVEEGIVLGG GCALLRCIPA LDSLTPANED QKIGIEIIKR TLKIPAMTIA
490 500 510 520 530 540
KNAGVEGSLI VEKIMQSSSE VGYDAMAGDF VNMVEKGIID PTKVVRTALL DAAGVASLLT
550 560 570
TAEVVVTEIP KEEKDPGMGA MGGMGGGMGG GMF
Isoforms
- Isoform 2 of 60 kDa heat shock protein, mitochondrialSequence View
10 20 30 40 50 60
MLRLPTVFRQ MRPVSRVLAP HLTRAYAKDV KFGADARALM LQGVDLLADA VAVTMGPKGR
70 80 90 100 110 120
TVIIEQSWGS PKVTKDGVTV AKSIDLKDKY KNIGAKLVQD VANNTNEEAG DGTTTATVLA
130 140 150 160 170 180
RSIAKEGFEK ISKGANPVEI RRGVMLAVDA VIAELKKQSK PVTTPEEIAQ VATISANGDK
190 200 210 220 230 240
EIGNIISDAM KKVGRKGVIT VKDGKTLNDE LEIIEGMKFD RGYISPYFIN TSKGQKCEFQ
250 260 270 280 290 300
DAYVLLSEKK ISSIQSIVPA LEIANAHRKP LVIIAEDVDG EALSTLVLNR LKVGLQVVAV
310 320 330 340 350 360
KAPGFGDNRK NQLKDMAIAT GGAVFGEEGL TLNLEDVQPH DLGKVGEVIV TKDDAMLLKG
370 380 390 400 410 420
KGDKAQIEKR IQEIIEQLDV TTSEYEKEKL NERLAKLSDG VAVLKVGGTS DVEVNEKKDR
430 440 450 460 470 480
VTDALNATRA AVEEGIVLGG GCALLRCIPA LDSLTPANED QKIGIEIIKR TLKIPAMTIA
490 500 510 520 530 540
KNAGVEGSLI VEKIMQSSSE VGYDAMAGDF VNMVEKGIID PTKVVRTALL DAAGVASLLT
550 560 570
TAEVVVTEIP KEEKDPGMGA MGGMGGGMGG GMF
Protein Neighborhood
Domains & Features
50 N-termini - 30 C-termini - 33 Cleavages - 0 Substrates
N-termini
Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
---|---|---|---|---|---|---|---|---|---|
P10809-11-unknown | MRPVSR... | 11 | inferred from electronic annotation | unknown | TISdb | inferred from TISdb | |||
P10809-18-unknown | LAPHLT... | 18 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC26468 | |||
P10809-26- | YAKDVK... | 26 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_bortezomib | 23264352 | |||
P10809-26- | YAKDVK... | 26 | Subtiligase Based Positive Selection | Wells | apoptosis_U266_bortezomib_induced | 23264352 | |||
P10809-27- | AKDVKF... | 27 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_bortezomib | 23264352 | |||
P10809-27- | AKDVKF... | 27 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_staurotrail | 23264352 | |||
P10809-27- | AKDVKF... | 27 | Subtiligase Based Positive Selection | Wells | apoptotic_MM1s_bort | 23264352 | |||
P10809-27- | AKDVKF... | 27 | Subtiligase Based Positive Selection | Wells | apoptosis_U266_bortezomib_induced | 23264352 | |||
P10809-27-unknown | AKDVKF... | 27 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
P10809-40-unknown | MLQGVD... | 40 | unknown | Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage... | 18722006 | ||||
P10809-40- | MLQGVD... | 40 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_Etoposide | 23264352 | |||
P10809-49-unknown | DAVAVT... | 49 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC17279 | |||
P10809-49-unknown | DAVAVT... | 49 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC18651 | |||
P10809-50-unknown | AVAVTM... | 50 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC1146 | |||
P10809-73-unknown | VTKDGV... | 73 | unknown | Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage... | 18722006 | ||||
P10809-73-unknown | VTKDGV... | 73 | unknown | Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage... | 18722006 | ||||
P10809-73- | VTKDGV... | 73 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_Etoposide | 23264352 | |||
P10809-99- | QDVANN... | 99 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_Etoposide | 23264352 | |||
P10809-99- | QDVANN... | 99 | Subtiligase Based Positive Selection | Wells | apopotic_Jurkat_FasL | 23264352 | |||
P10809-99-unknown | QDVANN... | 99 | unknown | Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage... | 18722006 | ||||
P10809-104- | NTNEEA... | 104 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_staurotrail | 23264352 | |||
P10809-104- | NTNEEA... | 104 | Subtiligase Based Positive Selection | Wells | apoptosis_U266_bortezomib_induced | 23264352 | |||
P10809-112- | GTTTAT... | 112 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_staurotrail | 23264352 | |||
P10809-147- | AVDAVI... | 147 | Subtiligase Based Positive Selection | Wells | apoptosis_U266_bortezomib_induced | 23264352 | |||
P10809-148-unknown | VDAVIA... | 148 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC17280 | |||
P10809-150-unknown | AVIAEL... | 150 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC17281 | |||
P10809-173- | TISANG... | 173 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_bortezomib | 23264352 | |||
P10809-178-unknown | GDKEIG... | 178 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC11168 | |||
P10809-207- | LNDELE... | 207 | Subtiligase Based Positive Selection | Wells | apopotic_Jurkat_FasL | 23264352 | |||
P10809-207-unknown | LNDELE... | 207 | unknown | Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage... | 18722006 | ||||
P10809-209-unknown | DELEII... | 209 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC17282 | |||
P10809-209-unknown | DELEII... | 209 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC18652 | |||
P10809-211-unknown | LEIIEG... | 211 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC18653 | |||
P10809-241-unknown | DAYVLL... | 241 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC18654 | |||
P10809-253- | SIQSIV... | 253 | Subtiligase Based Positive Selection | Wells | apoptotic_MM1s_bort | 23264352 | |||
P10809-256- | SIVPAL... | 256 | Subtiligase Based Positive Selection | Wells | apoptotic_MM1s_bort | 23264352 | |||
P10809-257-unknown | IVPALE... | 257 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC17283 | |||
P10809-257-unknown | IVPALE... | 257 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC18655 | |||
P10809-278-unknown | VDGEAL... | 278 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC11169 | |||
P10809-281-unknown | EALSTL... | 281 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC18656 | |||
P10809-299- | AVKAPG... | 299 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_staurotrail | 23264352 | |||
P10809-321- | GGAVFG... | 321 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_bortezomib | 23264352 | |||
P10809-321- | GGAVFG... | 321 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_staurotrail | 23264352 | |||
P10809-321- | GGAVFG... | 321 | Subtiligase Based Positive Selection | Wells | apoptotic_MM1s_bort | 23264352 | |||
P10809-321- | GGAVFG... | 321 | Subtiligase Based Positive Selection | Wells | MM1SDBJurkat_Untreated | 23264352 | |||
P10809-321- | GGAVFG... | 321 | Subtiligase Based Positive Selection | Wells | apoptosis_U266_bortezomib_induced | 23264352 | |||
P10809-329- | GLTLNL... | 329 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_staurotrail | 23264352 | |||
P10809-329- | GLTLNL... | 329 | Subtiligase Based Positive Selection | Wells | MM1SDBJurkat_Untreated | 23264352 | |||
P10809-331- | TLNLED... | 331 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_staurotrail | 23264352 | |||
P10809-336-unknown | DVQPHD... | 336 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC7275 | |||
P10809-336-unknown | DVQPHD... | 336 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC5544 | |||
P10809-380-unknown | VTTSEY... | 380 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC17284 | |||
P10809-382-unknown | TSEYEK... | 382 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC7276 | |||
P10809-408-unknown | GTSDVE... | 408 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC7277 | |||
P10809-408-unknown | GTSDVE... | 408 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC5545 | |||
P10809-408- | GTSDVE... | 408 | Subtiligase Based Positive Selection | Wells | apoptotic_MM1s_bort | 23264352 | |||
P10809-434-unknown | EGIVLG... | 434 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC17285 | |||
P10809-434-unknown | EGIVLG... | 434 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC18657 | |||
P10809-452-unknown | DSLTPA... | 452 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC17286 | |||
P10809-452-unknown | DSLTPA... | 452 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC18658 | |||
P10809-453- | SLTPAN... | 453 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_bortezomib | 23264352 | |||
P10809-453- | SLTPAN... | 453 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_staurotrail | 23264352 | |||
P10809-459-unknown | EDQKIG... | 459 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC17287 | |||
P10809-459-unknown | EDQKIG... | 459 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC18659 | |||
P10809-502- | GYDAMA... | 502 | Subtiligase Based Positive Selection | Wells | THP_untreated | 23264352 | |||
P10809-504-unknown | DAMAGD... | 504 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC17288 | |||
P10809-504-unknown | DAMAGD... | 504 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC18660 | |||
P10809-505-unknown | AMAGDF... | 505 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC11170 | |||
P10809-505- | AMAGDF... | 505 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_staurotrail | 23264352 | |||
P10809-508-unknown | GDFVNM... | 508 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC7278 | |||
P10809-509-unknown | DFVNMV... | 509 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC18661 | |||
P10809-543-unknown | EVVVTE... | 543 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC17289 |
C-termini
Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
...PVSRVL | 17 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC26468 | |||
...VDLLAD | 48 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC17279 | |||
...VDLLAD | 48 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC18651 | |||
...DLLADA | 49 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC1146 | |||
...TMGPKG | 58 | inferred from electronic annotation | unknown | Ensembl | inferred from ensembl protein ENSP00000412227 | |||
...TVAKSI | 83 | inferred from electronic annotation | unknown | Ensembl | inferred from ensembl protein ENSP00000402478 | |||
...YKNIGA | 94 | inferred from electronic annotation | unknown | Ensembl | inferred from ensembl protein ENSP00000396460 | |||
...EKISKG | 133 | inferred from electronic annotation | unknown | Ensembl | inferred from ensembl protein ENSP00000414446 | |||
...GVMLAV | 147 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC17280 | |||
...MLAVDA | 149 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC17281 | |||
...TISANG | 177 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC11168 | |||
...GKTLND | 208 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC17282 | |||
...GKTLND | 208 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC18652 | |||
...TLNDEL | 210 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC18653 | |||
...MKFDRG | 221 | inferred from electronic annotation | unknown | Ensembl | inferred from ensembl protein ENSP00000412717 | |||
...KCEFQD | 240 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC18654 | |||
...SSIQSI | 256 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC17283 | |||
...SSIQSI | 256 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC18655 | |||
...IIAEDV | 277 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC11169 | |||
...EDVDGE | 280 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC18656 | |||
...TLNLED | 335 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC7275 | |||
...TLNLED | 335 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC5544 | |||
...IEQLDV | 379 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC17284 | |||
...QLDVTT | 381 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC7276 | |||
...VLKVGG | 407 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC7277 | |||
...VLKVGG | 407 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC5545 | |||
...RAAVEE | 433 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC17285 | |||
...RAAVEE | 433 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC18657 | |||
...CIPALD | 451 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC17286 | |||
...CIPALD | 451 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC18658 | |||
...LTPANE | 458 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC17287 | |||
...LTPANE | 458 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC18659 | |||
...SEVGYD | 503 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC17288 | |||
...SEVGYD | 503 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC18660 | |||
...EVGYDA | 504 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC11170 | |||
...YDAMAG | 507 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC7278 | |||
...DAMAGD | 508 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC18661 | |||
...LLTTAE | 542 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC17289 | |||
...GGGMF | 573 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot |
Cleavages
Substrates
Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
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