O75439: Mitochondrial-processing peptidase subunit beta

General Information

Protein names	- Mitochondrial-processing peptidase subunit beta - 3.4.24.64 - Beta-MPP - P-52
Gene names	PMPCB
Organism	Homo sapiens
Protease Family	M16.003
Protease ID	M16.003
Chromosome location
UniProt ID	O75439

7 N-termini

1 C-termini

0 Cleavages

25 Substrates

Sequence

        10         20         30         40         50         60
MAAAAARVVL SSAARRRLWG FSESLLIRGA AGRSLYFGEN RLRSTQAATQ VVLNVPETRV
        70         80         90        100        110        120
TCLESGLRVA SEDSGLSTCT VGLWIDAGSR YENEKNNGTA HFLEHMAFKG TKKRSQLDLE
       130        140        150        160        170        180
LEIENMGAHL NAYTSREQTV YYAKAFSKDL PRAVEILADI IQNSTLGEAE IERERGVILR
       190        200        210        220        230        240
EMQEVETNLQ EVVFDYLHAT AYQNTALGRT ILGPTENIKS ISRKDLVDYI TTHYKGPRIV
       250        260        270        280        290        300
LAAAGGVSHD ELLDLAKFHF GDSLCTHKGE IPALPPCKFT GSEIRVRDDK MPLAHLAIAV
       310        320        330        340        350        360
EAVGWAHPDT ICLMVANTLI GNWDRSFGGG MNLSSKLAQL TCHGNLCHSF QSFNTSYTDT
       370        380        390        400        410        420
GLWGLYMVCE SSTVADMLHV VQKEWMRLCT SVTESEVARA RNLLKTNMLL QLDGSTPICE
       430        440        450        460        470        480
DIGRQMLCYN RRIPIPELEA RIDAVNAETI REVCTKYIYN RSPAIAAVGP IKQLPDFKQI

RSNMCWLRD

Isoforms

Sequence View

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
O75439-44-unknown	STQAAT...	44		unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
O75439-44-unknown	STQAAT...	44		unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
O75439-44-	STQAAT...	44		Subtiligase Based Positive Selection		Wells	DB_Untreated	23264352
O75439-44-	STQAAT...	44		Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
O75439-44-	STQAAT...	44		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
O75439-44-	STQAAT...	44		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
O75439-44-	STQAAT...	44		Subtiligase Based Positive Selection		Wells	apopotic_Jurkat_FasL	23264352
O75439-44-	STQAAT...	44		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
O75439-44-	STQAAT...	44		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
O75439-44-	STQAAT...	44		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
O75439-44-	STQAAT...	44		Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
O75439-44-	STQAAT...	44		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
O75439-44-	STQAAT...	44		Subtiligase Based Positive Selection		Wells	apoptotic_RPMI_Dox	23264352
O75439-44-	STQAAT...	44		Subtiligase Based Positive Selection		Wells	RMPI_untreated	23264352
O75439-44-	STQAAT...	44		Subtiligase Based Positive Selection		Wells	THP_untreated	23264352
O75439-44-	STQAAT...	44		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
O75439-46-unknown	QAATQV...	46	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O75439-46-	QAATQV...	46		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
O75439-47-	AATQVV...	47		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
O75439-50-	QVVLNV...	50		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
O75439-106-unknown	MAFKGT...	106	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000410393
O75439-106-unknown	MAFKGT...	106	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O75439-106-unknown	MAFKGT...	106	inferred from similarity	unknown	UniProtKB		inferred from uniprot (by similarity)

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
QCR6_HUMAN	13	TESG.\|.GDPE	inferred from experiment	unknown	MEROPS		Merops MPPB_HUMAN -> QCR6_HUMAN @13
ATPO_HUMAN	15	VRCF.\|.FSTS	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Caspase-specific and nonspecifi... (M16.003)	16179924,
OAT_HUMAN	17	SRGV.\|.VHSS	inferred from experiment	unknown	MEROPS	Ito A	Kitada S et al.:A protein from a parasitic micr... (M16.003)	17158683,
CH60_HUMAN	17	SRVL.\|.LAPH	inferred from experiment	unknown	MEROPS	Vandekerckhove J	Gevaert K et al.:Exploring proteomes and analyzi... (M24.028)	12665801,
ATPD_HUMAN	22	RAYA.\|.AEAA	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Caspase-specific and nonspecifi... (M16.003)	16179924,
DHRS2_HUMAN	23	VRMS.\|.SSTG	inferred from experiment	unknown	MEROPS	Melli M	Gabrielli F et al.:A nuclear protein, synthesized ... (M16.003)	7556196,
DHRS2-Isoform2_HUMAN	23	VRMS.\|.SSTG	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC26479
OTC_HUMAN	24	VRNF.\|.FRCG	inferred from experiment	unknown	MEROPS	Rosenberg LE	Hendrick JP et al.:Survey of amino-terminal proteo... (M16.003)	2657736,
ATP5J_HUMAN	24	RRNI.\|.IGVT	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Caspase-specific and nonspecifi... (M16.003)	16179924,
NDUV2_HUMAN	24	VRNL.\|.LHKT	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Caspase-specific and nonspecifi... (M16.003)	16179924,
ATPG_HUMAN	25	RNMA.\|.ATLK	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Caspase-specific and nonspecifi... (M16.003)	16179924,
ATPG-Isoform2_HUMAN	25	RNMA.\|.ATLK	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC26476
C560_HUMAN	29	AVPL.\|.LGTT	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Caspase-specific and nonspecifi... (M16.003)	16179924,
C560-Isoform2_HUMAN	29	AVPL.\|.LGTT	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC26487
ATP5J-Isoform2_HUMAN	32	RRNI.\|.IGVT	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC26469
ATPA_HUMAN	35	ARNF.\|.FHAS	inferred from experiment	unknown	MEROPS	Vandekerckhove J	Gevaert K et al.:Exploring proteomes and analyzi... (M24.028)	12665801,
ATPA-Isoform3_HUMAN	35	ARNF.\|.FHAS	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC26473
FRDA_HUMAN	41	RRGL.\|.LRTD	inferred from experiment	unknown	MEROPS	Isaya G	Cavadini P et al.:Two-step processing of human fr... (M16.003)	11020385,
FRDA-Isoform3_HUMAN	41	RRGL.\|.LRTD	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC26481
FRDA-Isoform2_HUMAN	41	RRGL.\|.LRTD	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC26481
AT5F1_HUMAN	42	HLVP.\|.PVPP	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Caspase-specific and nonspecifi... (M16.003)	16179924,
FUMH_HUMAN	44	ARMA.\|.ASQN	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Caspase-specific and nonspecifi... (M16.003)	16179924,
FRDA_HUMAN	55	RRAS.\|.SSNQ	inferred from experiment	unknown	MEROPS	Isaya G	Cavadini P et al.:Two-step processing of human fr... (M16.003)	11020385,
FRDA-Isoform3_HUMAN	55	RRAS.\|.SSNQ	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC26484
FRDA-Isoform2_HUMAN	55	RRAS.\|.SSNQ	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC26484

TopFIND

O75439: Mitochondrial-processing peptidase subunit beta

General Information

7

N-termini

1

C-termini

0

Cleavages

25

Substrates

Sequence

Isoforms

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Protein Neighborhood

Domains & Features

7 N-termini - 1 C-termini - 0 Cleavages - 25 Substrates

N-termini

C-termini

Cleavages

Substrates