P25705: ATP synthase subunit alpha, mitochondrial {ECO:0000305}

General Information

Protein names	- ATP synthase subunit alpha, mitochondrial {ECO:0000305} - ATP synthase F1 subunit alpha {ECO:0000312\|HGNC:HGNC:823}
Gene names	ATP5A1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P25705

16 N-termini

11 C-termini

5 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of ATP synthase subunit alpha, mitochondrial - Isoform 3 of ATP synthase subunit alpha, mitochondrial

Sequence View

        10         20         30         40         50         60
MLSVRVAAAV VRALPRRAGL VSRNALGSSF IAARNFHASN THLQKTGTAE MSSILEERIL
        70         80         90        100        110        120
GADTSVDLEE TGRVLSIGDG IARVHGLRNV QAEEMVEFSS GLKGMSLNLE PDNVGVVVFG
       130        140        150        160        170        180
NDKLIKEGDI VKRTGAIVDV PVGEELLGRV VDALGNAIDG KGPIGSKTRR RVGLKAPGII
       190        200        210        220        230        240
PRISVREPMQ TGIKAVDSLV PIGRGQRELI IGDRQTGKTS IAIDTIINQK RFNDGSDEKK
       250        260        270        280        290        300
KLYCIYVAIG QKRSTVAQLV KRLTDADAMK YTIVVSATAS DAAPLQYLAP YSGCSMGEYF
       310        320        330        340        350        360
RDNGKHALII YDDLSKQAVA YRQMSLLLRR PPGREAYPGD VFYLHSRLLE RAAKMNDAFG
       370        380        390        400        410        420
GGSLTALPVI ETQAGDVSAY IPTNVISITD GQIFLETELF YKGIRPAINV GLSVSRVGSA
       430        440        450        460        470        480
AQTRAMKQVA GTMKLELAQY REVAAFAQFG SDLDAATQQL LSRGVRLTEL LKQGQYSPMA
       490        500        510        520        530        540
IEEQVAVIYA GVRGYLDKLE PSKITKFENA FLSHVVSQHQ ALLGTIRADG KISEQSDAKL
       550
KEIVTNFLAG FEA         10         20         30         40         50         60
MLSVRVAAAV VRALPRRAGL VSRNALGSSF IAARNFHASN THLQKTGTAE MSSILEERIL
        70         80         90        100        110        120
GADTSVDLEE TGRVLSIGDG IARVHGLRNV QAEEMVEFSS GLKGMSLNLE PDNVGVVVFG
       130        140        150        160        170        180
NDKLIKEGDI VKRTGAIVDV PVGEELLGRV VDALGNAIDG KGPIGSKTRR RVGLKAPGII
       190        200        210        220        230        240
PRISVREPMQ TGIKAVDSLV PIGRGQRELI IGDRQTGKTS IAIDTIINQK RFNDGSDEKK
       250        260        270        280        290        300
KLYCIYVAIG QKRSTVAQLV KRLTDADAMK YTIVVSATAS DAAPLQYLAP YSGCSMGEYF
       310        320        330        340        350        360
RDNGKHALII YDDLSKQAVA YRQMSLLLRR PPGREAYPGD VFYLHSRLLE RAAKMNDAFG
       370        380        390        400        410        420
GGSLTALPVI ETQAGDVSAY IPTNVISITD GQIFLETELF YKGIRPAINV GLSVSRVGSA
       430        440        450        460        470        480
AQTRAMKQVA GTMKLELAQY REVAAFAQFG SDLDAATQQL LSRGVRLTEL LKQGQYSPMA
       490        500        510        520        530        540
IEEQVAVIYA GVRGYLDKLE PSKITKFENA FLSHVVSQHQ ALLGTIRADG KISEQSDAKL
       550
KEIVTNFLAG FEA

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

16 N-termini - 11 C-termini - 5 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P25705-1-unknown	MLSVRV...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt67939
P25705-36-unknown	FHASNT...	36	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC26473
P25705-36-unknown	FHASNT...	36	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt138029
P25705-44-	QKTGTA...	44		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P25705-44-	QKTGTA...	44		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P25705-44-	QKTGTA...	44		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P25705-44-	QKTGTA...	44		Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
P25705-44-	QKTGTA...	44		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P25705-44-	QKTGTA...	44		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P25705-44-unknown	QKTGTA...	44	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P25705-44-unknown	QKTGTA...	44	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt115525
P25705-45-	KTGTAE...	45		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P25705-45-	KTGTAE...	45		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
P25705-45-	KTGTAE...	45		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
P25705-45-	KTGTAE...	45		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P25705-45-	KTGTAE...	45		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P25705-45-	KTGTAE...	45		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P25705-45-unknown	KTGTAE...	45		unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P25705-45-unknown	KTGTAE...	45		unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P25705-45-unknown	KTGTAE...	45	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt159446
P25705-45-unknown	KTGTAE...	45	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P25705-45-unknown	KTGTAE...	45	inferred from similarity	unknown	UniProtKB		inferred from uniprot (by similarity)
P25705-47-	GTAEMS...	47		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P25705-47-	GTAEMS...	47		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P25705-47-	GTAEMS...	47		Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
P25705-47-	GTAEMS...	47		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P25705-47-unknown	GTAEMS...	47	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt170604
P25705-51-unknown	MSSILE...	51	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt67938
P25705-51-unknown	MSSILE...	51	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000465497
P25705-51-unknown	MSSILE...	51	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000465259
P25705-51-unknown	MSSILE...	51	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000467830
P25705-51-unknown	MSSILE...	51	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000465477
P25705-51-unknown	MSSILE...	51	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt101443
P25705-64-unknown	TSVDLE...	64	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11357
P25705-64-unknown	TSVDLE...	64	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt136471
P25705-64-unknown	TSVDLE...	64	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt140231
P25705-65-	SVDLEE...	65		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P25705-65-unknown	SVDLEE...	65	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt170607
P25705-65-unknown	SVDLEE...	65	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt170606
P25705-101-unknown	GLKGMS...	101	inferred from electronic annotation	unknown	TISdb		inferred from TISdb
P25705-101-unknown	GLKGMS...	101	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt196965
P25705-101-unknown	GLKGMS...	101	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt196964
P25705-140-unknown	VPVGEE...	140	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17532
P25705-140-unknown	VPVGEE...	140	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt141829
P25705-160-unknown	GKGPIG...	160	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1754
P25705-160-unknown	GKGPIG...	160	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt142961
P25705-225-unknown	TIINQK...	225	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11360
P25705-225-unknown	TIINQK...	225	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt145702
P25705-225-unknown	TIINQK...	225	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt146646

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...IAARNF	35	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26473
...IAARNF	35	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt121045
...ILGADT	63	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11357
...ILGADT	63	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt123349
...GAIVDV	139	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17532
...GAIVDV	139	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt125008
...GAIVDV	139	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt154268
...GNAIDG	159	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1754
...GNAIDG	159	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt126173
...AIDGKG	161	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000467830
...AIDGKG	161	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt155115
...QTGIKA	194	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000465259
...QTGIKA	194	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt155555
...QTGIKA	194	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt155554
...PIGRGQ	205	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000468458
...PIGRGQ	205	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt155693
...PIGRGQ	205	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt155692
...SIAIDT	224	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11360
...SIAIDT	224	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt129000
...SIAIDT	224	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt129955
...RSTVAQ	257	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000465497
...PLQYLA	288	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000466975
...AGFEA	553	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...AGFEA	553	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt63556
...AGFEA	553	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt63557

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MPPB_HUMAN	35	ARNF.\|.FHAS	inferred from experiment	unknown	MEROPS	Vandekerckhove J	Gevaert K et al.:Exploring proteomes and analyzi... (M24.028)	12665801,
GRAB_HUMAN	63	GADT.\|.TSVD	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,
MEP1A_HUMAN	139	IVDV.\|.VPVG	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
CASP3_HUMAN	159	AIDG.\|.GKGP	inferred from experiment	unknown	MEROPS		Merops CASP3_HUMAN -> ATPA_HUMAN @159
GRAB_HUMAN	224	AIDT.\|.TIIN	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)