P25705: ATP synthase subunit alpha, mitochondrial {ECO:0000305}
Protein names | - ATP synthase subunit alpha, mitochondrial {ECO:0000305} - ATP synthase F1 subunit alpha {ECO:0000312|HGNC:HGNC:823} |
---|---|
Gene names | ATP5A1 |
Organism | Homo sapiens |
Protease Family | |
Protease ID | |
Chromosome location | |
UniProt ID | P25705 |
16
N-termini
11
C-termini
5
Cleavages
0
Substrates
Sequence
10 20 30 40 50 60
MLSVRVAAAV VRALPRRAGL VSRNALGSSF IAARNFHASN THLQKTGTAE MSSILEERIL
70 80 90 100 110 120
GADTSVDLEE TGRVLSIGDG IARVHGLRNV QAEEMVEFSS GLKGMSLNLE PDNVGVVVFG
130 140 150 160 170 180
NDKLIKEGDI VKRTGAIVDV PVGEELLGRV VDALGNAIDG KGPIGSKTRR RVGLKAPGII
190 200 210 220 230 240
PRISVREPMQ TGIKAVDSLV PIGRGQRELI IGDRQTGKTS IAIDTIINQK RFNDGSDEKK
250 260 270 280 290 300
KLYCIYVAIG QKRSTVAQLV KRLTDADAMK YTIVVSATAS DAAPLQYLAP YSGCSMGEYF
310 320 330 340 350 360
RDNGKHALII YDDLSKQAVA YRQMSLLLRR PPGREAYPGD VFYLHSRLLE RAAKMNDAFG
370 380 390 400 410 420
GGSLTALPVI ETQAGDVSAY IPTNVISITD GQIFLETELF YKGIRPAINV GLSVSRVGSA
430 440 450 460 470 480
AQTRAMKQVA GTMKLELAQY REVAAFAQFG SDLDAATQQL LSRGVRLTEL LKQGQYSPMA
490 500 510 520 530 540
IEEQVAVIYA GVRGYLDKLE PSKITKFENA FLSHVVSQHQ ALLGTIRADG KISEQSDAKL
550
KEIVTNFLAG FEA
Isoforms
- Isoform 2 of ATP synthase subunit alpha, mitochondrial - Isoform 3 of ATP synthase subunit alpha, mitochondrialSequence View
10 20 30 40 50 60
MLSVRVAAAV VRALPRRAGL VSRNALGSSF IAARNFHASN THLQKTGTAE MSSILEERIL
70 80 90 100 110 120
GADTSVDLEE TGRVLSIGDG IARVHGLRNV QAEEMVEFSS GLKGMSLNLE PDNVGVVVFG
130 140 150 160 170 180
NDKLIKEGDI VKRTGAIVDV PVGEELLGRV VDALGNAIDG KGPIGSKTRR RVGLKAPGII
190 200 210 220 230 240
PRISVREPMQ TGIKAVDSLV PIGRGQRELI IGDRQTGKTS IAIDTIINQK RFNDGSDEKK
250 260 270 280 290 300
KLYCIYVAIG QKRSTVAQLV KRLTDADAMK YTIVVSATAS DAAPLQYLAP YSGCSMGEYF
310 320 330 340 350 360
RDNGKHALII YDDLSKQAVA YRQMSLLLRR PPGREAYPGD VFYLHSRLLE RAAKMNDAFG
370 380 390 400 410 420
GGSLTALPVI ETQAGDVSAY IPTNVISITD GQIFLETELF YKGIRPAINV GLSVSRVGSA
430 440 450 460 470 480
AQTRAMKQVA GTMKLELAQY REVAAFAQFG SDLDAATQQL LSRGVRLTEL LKQGQYSPMA
490 500 510 520 530 540
IEEQVAVIYA GVRGYLDKLE PSKITKFENA FLSHVVSQHQ ALLGTIRADG KISEQSDAKL
550
KEIVTNFLAG FEA
10 20 30 40 50 60
MLSVRVAAAV VRALPRRAGL VSRNALGSSF IAARNFHASN THLQKTGTAE MSSILEERIL
70 80 90 100 110 120
GADTSVDLEE TGRVLSIGDG IARVHGLRNV QAEEMVEFSS GLKGMSLNLE PDNVGVVVFG
130 140 150 160 170 180
NDKLIKEGDI VKRTGAIVDV PVGEELLGRV VDALGNAIDG KGPIGSKTRR RVGLKAPGII
190 200 210 220 230 240
PRISVREPMQ TGIKAVDSLV PIGRGQRELI IGDRQTGKTS IAIDTIINQK RFNDGSDEKK
250 260 270 280 290 300
KLYCIYVAIG QKRSTVAQLV KRLTDADAMK YTIVVSATAS DAAPLQYLAP YSGCSMGEYF
310 320 330 340 350 360
RDNGKHALII YDDLSKQAVA YRQMSLLLRR PPGREAYPGD VFYLHSRLLE RAAKMNDAFG
370 380 390 400 410 420
GGSLTALPVI ETQAGDVSAY IPTNVISITD GQIFLETELF YKGIRPAINV GLSVSRVGSA
430 440 450 460 470 480
AQTRAMKQVA GTMKLELAQY REVAAFAQFG SDLDAATQQL LSRGVRLTEL LKQGQYSPMA
490 500 510 520 530 540
IEEQVAVIYA GVRGYLDKLE PSKITKFENA FLSHVVSQHQ ALLGTIRADG KISEQSDAKL
550
KEIVTNFLAG FEA
Protein Neighborhood
Domains & Features
16 N-termini - 11 C-termini - 5 Cleavages - 0 Substrates
N-termini
Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
---|---|---|---|---|---|---|---|---|---|
P25705-1-unknown | MLSVRV... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt67939 | |||
P25705-36-unknown | FHASNT... | 36 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC26473 | |||
P25705-36-unknown | FHASNT... | 36 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt138029 | |||
P25705-44- | QKTGTA... | 44 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_bortezomib | 23264352 | |||
P25705-44- | QKTGTA... | 44 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_staurotrail | 23264352 | |||
P25705-44- | QKTGTA... | 44 | Subtiligase Based Positive Selection | Wells | apoptotic_MM1s_bort | 23264352 | |||
P25705-44- | QKTGTA... | 44 | Subtiligase Based Positive Selection | Wells | MM1SDBJurkat_Untreated | 23264352 | |||
P25705-44- | QKTGTA... | 44 | Subtiligase Based Positive Selection | Wells | apoptotic_MM1SDBJurkat_Mix | 23264352 | |||
P25705-44- | QKTGTA... | 44 | Subtiligase Based Positive Selection | Wells | apoptosis_U266_bortezomib_induced | 23264352 | |||
P25705-44-unknown | QKTGTA... | 44 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
P25705-44-unknown | QKTGTA... | 44 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt115525 | |||
P25705-45- | KTGTAE... | 45 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_bortezomib | 23264352 | |||
P25705-45- | KTGTAE... | 45 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_Etoposide | 23264352 | |||
P25705-45- | KTGTAE... | 45 | Subtiligase Based Positive Selection | Wells | Jurkat_untreated | 23264352 | |||
P25705-45- | KTGTAE... | 45 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_staurotrail | 23264352 | |||
P25705-45- | KTGTAE... | 45 | Subtiligase Based Positive Selection | Wells | apoptotic_MM1SDBJurkat_Mix | 23264352 | |||
P25705-45- | KTGTAE... | 45 | Subtiligase Based Positive Selection | Wells | apoptosis_U266_bortezomib_induced | 23264352 | |||
P25705-45-unknown | KTGTAE... | 45 | unknown | Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage... | 18722006 | ||||
P25705-45-unknown | KTGTAE... | 45 | unknown | Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage... | 18722006 | ||||
P25705-45-unknown | KTGTAE... | 45 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt159446 | |||
P25705-45-unknown | KTGTAE... | 45 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
P25705-45-unknown | KTGTAE... | 45 | inferred from similarity | unknown | UniProtKB | inferred from uniprot (by similarity) | |||
P25705-47- | GTAEMS... | 47 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_staurotrail | 23264352 | |||
P25705-47- | GTAEMS... | 47 | Subtiligase Based Positive Selection | Wells | apoptotic_MM1s_bort | 23264352 | |||
P25705-47- | GTAEMS... | 47 | Subtiligase Based Positive Selection | Wells | MM1SDBJurkat_Untreated | 23264352 | |||
P25705-47- | GTAEMS... | 47 | Subtiligase Based Positive Selection | Wells | apoptotic_MM1SDBJurkat_Mix | 23264352 | |||
P25705-47-unknown | GTAEMS... | 47 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt170604 | |||
P25705-51-unknown | MSSILE... | 51 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt67938 | |||
P25705-51-unknown | MSSILE... | 51 | inferred from electronic annotation | unknown | Ensembl | inferred from ensembl protein ENSP00000465497 | |||
P25705-51-unknown | MSSILE... | 51 | inferred from electronic annotation | unknown | Ensembl | inferred from ensembl protein ENSP00000465259 | |||
P25705-51-unknown | MSSILE... | 51 | inferred from electronic annotation | unknown | Ensembl | inferred from ensembl protein ENSP00000467830 | |||
P25705-51-unknown | MSSILE... | 51 | inferred from electronic annotation | unknown | Ensembl | inferred from ensembl protein ENSP00000465477 | |||
P25705-51-unknown | MSSILE... | 51 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt101443 | |||
P25705-64-unknown | TSVDLE... | 64 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC11357 | |||
P25705-64-unknown | TSVDLE... | 64 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt136471 | |||
P25705-64-unknown | TSVDLE... | 64 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt140231 | |||
P25705-65- | SVDLEE... | 65 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_staurotrail | 23264352 | |||
P25705-65-unknown | SVDLEE... | 65 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt170607 | |||
P25705-65-unknown | SVDLEE... | 65 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt170606 | |||
P25705-101-unknown | GLKGMS... | 101 | inferred from electronic annotation | unknown | TISdb | inferred from TISdb | |||
P25705-101-unknown | GLKGMS... | 101 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt196965 | |||
P25705-101-unknown | GLKGMS... | 101 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt196964 | |||
P25705-140-unknown | VPVGEE... | 140 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC17532 | |||
P25705-140-unknown | VPVGEE... | 140 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt141829 | |||
P25705-160-unknown | GKGPIG... | 160 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC1754 | |||
P25705-160-unknown | GKGPIG... | 160 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt142961 | |||
P25705-225-unknown | TIINQK... | 225 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC11360 | |||
P25705-225-unknown | TIINQK... | 225 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt145702 | |||
P25705-225-unknown | TIINQK... | 225 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt146646 |
C-termini
Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
...IAARNF | 35 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC26473 | |||
...IAARNF | 35 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt121045 | |||
...ILGADT | 63 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC11357 | |||
...ILGADT | 63 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt123349 | |||
...GAIVDV | 139 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC17532 | |||
...GAIVDV | 139 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt125008 | |||
...GAIVDV | 139 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt154268 | |||
...GNAIDG | 159 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC1754 | |||
...GNAIDG | 159 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt126173 | |||
...AIDGKG | 161 | inferred from electronic annotation | unknown | Ensembl | inferred from ensembl protein ENSP00000467830 | |||
...AIDGKG | 161 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt155115 | |||
...QTGIKA | 194 | inferred from electronic annotation | unknown | Ensembl | inferred from ensembl protein ENSP00000465259 | |||
...QTGIKA | 194 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt155555 | |||
...QTGIKA | 194 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt155554 | |||
...PIGRGQ | 205 | inferred from electronic annotation | unknown | Ensembl | inferred from ensembl protein ENSP00000468458 | |||
...PIGRGQ | 205 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt155693 | |||
...PIGRGQ | 205 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt155692 | |||
...SIAIDT | 224 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC11360 | |||
...SIAIDT | 224 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt129000 | |||
...SIAIDT | 224 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt129955 | |||
...RSTVAQ | 257 | inferred from electronic annotation | unknown | Ensembl | inferred from ensembl protein ENSP00000465497 | |||
...PLQYLA | 288 | inferred from electronic annotation | unknown | Ensembl | inferred from ensembl protein ENSP00000466975 | |||
...AGFEA | 553 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
...AGFEA | 553 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt63556 | |||
...AGFEA | 553 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt63557 |
Cleavages
Protease | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
MPPB_HUMAN | 35 | ARNF.|.FHAS | inferred from experiment | unknown | MEROPS | Vandekerckhove J | Gevaert K et al.:Exploring proteomes and analyzi... (M24.028) | 12665801, |
GRAB_HUMAN | 63 | GADT.|.TSVD | inferred from experiment | unknown | MEROPS | Gevaert K | Van Damme P et al.:Analysis of protein processing ... (S01.010) | 18836177, |
MEP1A_HUMAN | 139 | IVDV.|.VPVG | inferred from experiment | unknown | MEROPS | Overall CM | Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002) | 21693781, |
CASP3_HUMAN | 159 | AIDG.|.GKGP | inferred from experiment | unknown | MEROPS | Merops CASP3_HUMAN -> ATPA_HUMAN @159 | ||
GRAB_HUMAN | 224 | AIDT.|.TIIN | inferred from experiment | unknown | MEROPS | Gevaert K | Van Damme P et al.:Analysis of protein processing ... (S01.010) | 18836177, |
Substrates
Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|